5M: Multi-Instance Multi-Cluster based Weakly Supervised MIL Model for Multimedia Data Mining

The high pace rise in online as well as offline multimedia unannotated data and associated mining applications have demanded certain efficient mining algorithm. Multiple instance learning (MIL) has emerged as one of the most effective solutions for huge unannotated data mining. Still, it requires enhancement in instance selection to enable optimal mining and classification of huge multimedia data. Considering critical multimedia mining applications, such as medical data processing or content based information retrieval, the instance verification can be of great significance to optimize MIL. With this motivation, in this paper, Multi-Instance, Multi-Cluster based MIL scheme (MIMC-MIL) has been proposed to perform efficient multimedia data mining and classification with huge unannotated data with different features. The proposed system employs softmax approximation techniques with a novel loss factor and inter-instance distance based weight estimation scheme for instance probability substantiation in bags

Antimicrobial, Wound Healing And Antioxidant Activities Of Anthocephalus cadamba

Anthocephalus cadamba (Roxb.) Miq. Syn A. chinensis (Lamk) A. Rich (Rubiaceae) is ethnomedicinally widely used in the form of paste by tribe in western Ghats for treating skin diseases. In this context, antimicrobial potential of A. cadamba against a wide range of microorganisms was studied. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied, besides antioxidant activity to understand the mechanism of wound healing. The alchoholic and aqueous extract of this plant showed significant antibacterial and antifungal activity against almost all the organisms: Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and four fungi Candida albicans, Trichophyton rubrum—dermatophyte fungi, Aspergillus niger, Aspergillus flavus and Aspergillus nidulans—systemic fungi, with especially good activity against the dermatophyte (Trichophyton rubrum) and some infectious bacteria (Escherichia coli, Proteus mirabilis and Staphylococcus aureus) with an MIC of 2.5 μg/disc. The results show that A. cadamba extract has potent wound healing capacity as shown from the wound contraction and increased tensile strength. The results also indicated that A. cadamba extract possesses potent antioxidant activity by inhibiting lipid peroxidation and increase in the superoxide dismutase (SOD) and catalase activity. Keywords: Anthocephalus cadamba; Antimicrobial activity; Antioxidant; Wound healing;African Journal of Traditional and Complementary Medicine Vol. 4 (4) 2007: pp. 481-48

Dengue fever presenting as acute liver failure— a case report

AbstractDengue fever (DF) and dengue haemorrhagic fever (DHF) are important mosquito-borne viral diseases of humans and recognized as important emerging infectious diseases in the tropics and subtropics. Compared to nine reporting countries in the 1950s, today the geographic distribution includes more than 100 countries worldwide. Dengue viral infections are known to present a diverse clinical spectrum, ranging from asymptomatic illness to fatal dengue shock syndrome. Mild hepatic dysfunction in dengue haemorrhagic fever is usual. However, its presentation as acute liver failure (ALF) is unusual. We report a patient with dengue shock syndrome who presented with acute liver failure and hepatic encephalopathy in a recent outbreak of dengue fever in Delhi, India

An unusual case of posterior vaginal wall cyst

Vaginal cysts are rare and are mostly detected as an incidental finding during a gynecological examination. The commonest type of simple vaginal cyst is the Mullerian cyst arising from paramesonephric duct remnants. These are typically lined by columnar epithelium and contain serous or mucinous fluid. A 41 year old multiparous woman presented with mass per vagina since 6 months. On examination, posterior vaginal wall cyst of 8 x 4 x 3 cm was detected. Surgical excision of the cyst was done under spinal anaesthesia by sharp and blunt dissection. The cyst was filled with mucoid material and histopathological examination confirmed mullerian origin. This is a rare presentation of mullerian cysts developing posteriorly

Sea level changes along the Indian coast: Observations and projections

Sea level changes can be of two types: (i) changes in the mean sea level and (ii) changes in the extreme sea level. The former is a global phenomenon while the latter is a regional phenomenon. Estimates of mean sea level rise made from past tide gauge data at selected stations along the coast of India indicate a rise of slightly less than 1 mm/year; however these estimates need to be corrected by including the rates of vertical land movements, whose measurements are not available at present. Simulation results of a regional climate model, HadRM2, were analysed for the northern Indian Ocean to provide the future scenarios of the occurrence of tropical cyclones in the Bay of Bengal for the period 2041-60. This model simulations consist of a control run with concentration of CO2 kept constant at 1990 levels and a perturbed run with transient increase in the concentrations of CO2 (GHG) according to the IS92a scenario for the period 2041-2060. The simulation results show increase in frequencies of tropical cyclones in the Bay, particularly intense events during the postmonsoon period, for the increased GHG run. A storm surge model was used to compute the surges associated with the cyclones generated by the climate model. The storm surge model was forced by the wind field from HadRM2 over the model domain and tides prescribed along the open boundary from a global tidal model. The frequency of high surges is found to be higher in the model run forced by winds from increased GHG run than in the model run forced by winds from the control run

Assessment of spatio-temporal variations in surface water quality of Ghaggar River (North-Western, India) utilized for drinking and agricultural purposes

In the present study, statistical analyses (descriptive and principal component analysis) were applied to Ghaggar River surface water data set monitored in the month of June 2006 and 2007 to check spatio-temporal variations in water quality. From these, two summer observations were taken into consideration because in summer season, high concentrations are observed for different water constituents. The various physico-chemical constituents like pH, total dissolved solids (TDS), electrical conductivity (EC), temperature, Cl-, HCO3-, CO32-, Na+, K+, Ca2+, Mg2+, F-, SO42- and PO43- were analyzed. Statistical results revealed that water quality variables were totally different during the two summer observations.Keywords: Principal component analysis, spatio-temporal variations, water quality, summer season

Biological evaluation of 5-fluorouracil nanoparticles for cancer chemotherapy and its dependence on the carrier, PLGA

Nanoscaled devices have great potential for drug delivery applications due to their small size. In the present study, we report for the first time the preparation and evaluation of antitumor efficacy of 5-fluorouracil (5-FU)-entrapped poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles with dependence on the lactide/glycolide combination of PLGA. 5-FU-loaded PLGA nanoparticles with two different monomer combinations, 50-50 and 90-10 were synthesized using a modified double emulsion method, and their biological evaluation was done in glioma (U87MG) and breast adenocarcinoma (MCF7) cell lines. 5-FU-entrapped PLGA 50-50 nanoparticles showed smaller size with a high encapsulation efficiency of 66%, which was equivalent to that of PLGA 90-10 nanoparticles. Physicochemical characterization of nanoparticles using differential scanning calorimetry and X-ray diffraction suggested the presence of 5-FU in molecular dispersion form. In vitro release studies showed the prolonged and sustained release of 5-FU from nanoparticles with both the PLGA combinations, where PLGA 50-50 nanoparticles showed faster release. Nanoparticles with PLGA 50-50 combination exhibited better cytotoxicity than free drug in a dose- and time-dependent manner against both the tumor cell lines. The enhanced efficiency of PLGA 50-50 nanoparticles to induce apoptosis was indicated by acridine orange/ethidium bromide staining. Cell cycle perturbations studied using flow cytometer showed better S-phase arrest by nanoparticles in comparison with free 5-FU. All the results indicate that PLGA 50-50 nanoparticles possess better antitumor efficacy than PLGA 90-10 nanoparticles and free 5-FU. Since, studies have shown that long-term exposure of ailing tissues to moderate drug concentrations is more favorable than regular administration of higher concentration of the drug; our results clearly indicate the potential of 5-FU-loaded PLGA nanoparticles with dependence on carrier combination as controlled release formulation to multiplex the therapeutic effect of cancer chemotherapy

Prospective study on sociodynamics of cellulitis in general surgical unit

Background: Cellulitis is a potentially serious infection that commonly recurs. The identification of preventable dynamic factors could reduce infection related morbidity and cost and improve patient management. The aim of this study was to identify the dynamic factors associated with cellulitis, including analysis of risk factors associated with cellulitis in either limb and in other parts of the body.Methods: We conducted a prospective study on 110 patients with cellulitis in either limb and in other parts of the body, who were admitted in septic ward of all units of King George hospital between period of December 2013 to December 2014. The factors such as low socioeconomic status, illiteracy, rural area, nutritional status and associated co-morbid conditions and their effect on outcome of patient were studied. Univariate analyses were performed to describe the study.Results: The median age of the participants was 62.5 years. The following risk factors were strongly and independently associated with cellulitis and outcome of the patient; illiteracy (OR, 4; P value 0.010), age above 50 years (OR, 0.110; P value 0.000), residing in rural areas (OR, 4.008; P value 0.006), low socioeconomic status (OR, 0.241; P value 0.030) and associated co-morbid conditions (OR, 0.390; P value, 0.032).Conclusion: Patients usually presented in the late stage of disease because of illiteracy, ignorance and poor knowledge. Patients should be educated to routinely inspect their feet, and the importance of appropriate footwear should be emphasized. Patients who are actively involved in their care can improve their quality of life and have a better outcome.