Rapidity distribution as a probe for elliptical flow at intermediate energies

Interplay between the spectator and participant matter in heavy-ion collisions is investigated within isospin dependent quantum molecular dynamics (IQMD) model in term of rapidity distribution of light charged particles. The effect of different types and size rapidity distributions is studied in elliptical flow. The elliptical flow patterns show important role of the nearby spectator matter on the participant zone. This role is further explained on the basis of passing time of the spectator and expansion time of the participant zone. The transition from the in-plane to out-of-plane is observed only when the mid-rapidity region is included in the rapidity bin, otherwise no transition occurs. The transition energy is found to be highly sensitive towards the size of the rapidity bin, while weakly on the type of the rapidity distribution. The theoretical results are also compared with the experimental findings and are found in good agreement.Comment: 8 figure

Mutated Hilltop Inflation : A Natural Choice for Early Universe

We propose a model of inflation with a suitable potential for a single scalar field which falls in the wide class of hilltop inflation. We derive the analytical expressions for most of the physical quantities related to inflation and show that all of them represent the true behavior as required from a model of inflation. We further subject the results to observational verification by formulating the theory of perturbations based on our model followed by an estimation for the values of those observable parameters. Our model is found to be in excellent agreement with observational data. Thus, the features related to the model leads us to infer that this type of hilltop inflation may be a natural choice for explaining the early universe.Comment: 22 pages, 7 figures, 2 tables. Matches published version in JCA

Changes in the Quality Attributes of Edible Vegetable Oils During Deep Frying Concerning Defence Ration

Deep fat frying is a popular cooking method that can significantly alter the physico-chemical properties of edible oils. This unit operation is very common both in civil as well as institutional level training, recreational and feeding centres owing to the high liking of fried products among all age groups. Frying is a high-temperature process where food material is normally exposed to longer periods depending upon its moisture content and results in the desirable colour, aroma and taste that is most acceptable to the consumers. But the quality of oil changes each after the frying cycle and leads to the onset of various physicochemical changes resulting in the accumulation of toxic compounds that may pose potential health risks. Various edible oils from plant sources have varied stability against high-temperature exposure, hence, the selection of appropriate edible vegetable oils for deep frying is critical to ensure its safety during repeated use. The current article summarizes the available literature on the changes in quality attributes of edible vegetable oils during deep frying along with the mechanisms of oil degradation, including oxidation and hydrolysis, formation of trans fats, and major concerns during deep frying. This also covers various methods of assessing the quality of frying oils, inclusive of measurement of free fatty acids, peroxide value, polar compounds, and oxidative stability. The impact of deep frying on the nutritional value of edible vegetable oils, such as changes in fatty acid composition, effects of different frying conditions, such as temperature and time, on the quality of the frying oil and the loss of antioxidant compounds is also discussed rationally The facts and finding covered under present manuscript will be useful to food manufacturers and consumers in selecting appropriate edible vegetable oils for deep frying, maintaining the desired food quality, and ensuring the safety of various edible oils and their blends concerning both civil and the Defence supplies

EFFECT OF C-GLYCOSYL FLAVONE FROM URGINEA INDICA ON ANTIBIOTIC INDUCED MICROBIAL CELL DEATH

Objective: The aim of the present study was to isolate and characterize C-glycosyl flavone from Urgenia. indica bulb and to evaluate its effect on microbial cell growth.Methods: Methanolic extract of U. indica bulb was prepared using Soxhlation. Isolation was performed using silica gel column chromatography, and characterization was done based on IR, NMR and mass spectral data. The effect of C-glycosyl flavone was evaluated on microbial growth inhibition C-glycosyl flavone in terms of cytotoxicity, cell membrane damage, and cell death.Results: The results indicates that O-glycosyl flavanone (5,41-di hydroxyl-31-methoxy-7-O-[(α-L-rhamnosyl-(1[11]1-6[11])-β-D-glucopyranosyl)] flavanone), O-glycosyl flavone (5,41-dihydroxy-31-methoxy-7-O-β-D-glucopyranosyl flavone) and C-glycosyl flavone (5,7-dihydroxy-2-[41-hydroxy-31-(methoxymethyl) phenyl]-6-C-β-glucopyranosyl flavones) showed significantly sensitivity against Staphylococcus aureus, Bacillus subtilis, Rhizopus oryzae and Aspergillus niger. Synergism of C-glycosyl flavone on antibacterial activity of ciprofloxacin with the FIC index of 0.3 against S. aureus and 0.5 against B. subtilis. Antifungal activity of clotrimazole with the FIC index 0.3 against R. oryzae and 0.48 against A. niger. C-glycosyl flavone increased the ciprofloxacin-induced cytotoxicity from 63 to 91% against S. aureus and 56 to 89% against B. subtilis, whereas clotrimazole is induced cytotoxicity from 36 to 49% against R. oryzae and 23 to 41% against A. niger. C-glycosyl flavone increased the ciprofloxacin-induced cell death in S. aureus and B. subtilis and clotrimazole induced cell death in R. oryzae and A. niger as evident by propidium iodide staining, Tunel positive cells, and cytoplasmic membrane damage.Conclusion: The present investigation provides scientific and rationalism for the folkloric use of U. indica as an antimicrobial agent.Keywords: Antimicrobial, Synergism, Cytotoxicity, Cytoplasmic membrane damage and cell deathÂ

Dynamics of ions in the selectivity filter of the KcsA channel

The statistical and dynamical properties of ions in the selectivity filter of the KcsA ion channel are considered on the basis of molecular dynamics (MD) simulations of the KcsA protein embedded in a lipid membrane surrounded by an ionic solution. A new approach to the derivation of a Brownian dynamics (BD) model of ion permeation through the filter is discussed, based on unbiased MD simulations. It is shown that depending on additional assumptions, ion’s dynamics can be described either by under-damped Langevin equation with constant damping and white noise or by Langevin equation with a fractional memory kernel. A comparison of the potential of the mean force derived from unbiased MD simulations with the potential produced by the umbrella sampling method demonstrates significant differences in these potentials. The origin of these differences is an open question that requires further clarifications

PDF and scale uncertainties of various DY distributions in ADD and RS models at hadron colliders

In the extra dimension models of ADD and RS we study the dependence of the various parton distribution functions on observable of Drell-Yan process to NLO in QCD at LHC and Tevatron energies. Uncertainties at LHC due to factorisation scales in going from leading to next-to-leading order in QCD for the various distributions get reduced by about 2.75 times for a $\mu_F$ range $0.5 ~Q < \mu_F < 1.5 ~Q$. Further uncertainties arising from the error on experimental data are estimated using the MRST parton distribution functions.Comment: 27 pages, 11 figures, the version to appear in European Physical Journal

Topological B-Model on Weighted Projective Spaces and Self-Dual Models in Four Dimensions

It was recently shown by Witten on the basis of several examples that the topological B-model whose target space is a Calabi-Yau (CY) supermanifold is equivalent to holomorphic Chern-Simons (hCS) theory on the same supermanifold. Moreover, for the supertwistor space CP^{3|4} as target space, it has been demonstrated that hCS theory on CP^{3|4} is equivalent to self-dual N=4 super Yang-Mills (SYM) theory in four dimensions. We consider as target spaces for the B-model the weighted projective spaces WCP^{3|2}(1,1,1,1|p,q) with two fermionic coordinates of weight p and q, respectively - which are CY supermanifolds for p+q=4 - and discuss hCS theory on them. By using twistor techniques, we obtain certain field theories in four dimensions which are equivalent to hCS theory. These theories turn out to be self-dual truncations of N=4 SYM theory or of its twisted (topological) version.Comment: 12 pages; v2: minor clarification, 3 references added, published versio

Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid

Peptide mediated gain-of-toxic function is central to pathology in Alzheimer's, Parkinson's and diabetes. In each system, self-assembly into oligomers is observed and can also result in poration of artificial membranes. Structural requirements for poration and the relationship of structure to cytotoxicity is unaddressed. Here we focus on islet amyloid polypeptide (IAPP) mediated loss-of-insulin secreting cells in patients with diabetes. Newly developed methods enable structure-function enquiry to focus on intracellular oligomers composed of hundreds of IAPP. The key insights are that porating oligomers are internally dynamic, grow in discrete steps and are not canonical amyloid. Moreover, two classes of poration occur; an IAPP-specific ligand establishes that only one is cytotoxic. Toxic rescue occurs by stabilising non-toxic poration without displacing IAPP from mitochondria. These insights illuminate cytotoxic mechanism in diabetes and also provide a generalisable approach for enquiry applicable to other partially ordered protein assemblies