Three-Dimensional Myoarchitecture of the Lower Esophageal Sphincter and Esophageal Hiatus Using Optical Sectioning Microscopy.

Studies to date have failed to reveal the anatomical counterpart of the lower esophageal sphincter (LES). We assessed the LES and esophageal hiatus morphology using a block containing the human LES and crural diaphragm, serially sectioned at 50 μm intervals and imaged at 8.2 μm/pixel resolution. A 3D reconstruction of the tissue block was reconstructed in which each of the 652 cross sectional images were also segmented to identify the boundaries of longitudinal (LM) and circular muscle (CM) layers. The CM fascicles on the ventral surface of LES are arranged in a helical/spiral fashion. On the other hand, the CM fascicles from the two sides cross midline on dorsal surface and continue as sling/oblique muscle on the stomach. Some of the LM fascicles of the esophagus leave the esophagus to enter into the crural diaphragm and the remainder terminate into the sling fibers of the stomach. The muscle fascicles of the right crus of diaphragm which form the esophageal hiatus are arranged like a "noose" around the esophagus. We propose that circumferential squeeze of the LES and crural diaphragm is generated by a unique myo-architectural design, each of which forms a "noose" around the esophagus

Evaluation of Fungicides against Leaf Blotch of Turmeric Caused by Taphrina maculans Butler

A field experiment was conducted in the first fortnight of July 2008, 2009 and 2010 at Horticultural Research Station, Jagtial, and in 2010-2011 at Turmeric Research Station, Kammarpally, to evaluate various fungicides against leaf blotch of turmeric. Treatments included the fungicides Propiconazole (0.1%), Hexaconazole (0.1%), Tricyclazole (0.1%) and Carbendazim + Mancozeb (0.1%) for rhizome treatment (dipping) and for foliar spray at 45 and 90 days after planting (DAP); and foliar application alone at 45 and 90 DAP. Among the treatments, rhizome treatment with Carbendazim + Mancozeb (0.1%) gave the best germination (90.52%); Rhizome treatment followed by foliar application of Carbendazim + Mancozeb (0.1%) at 45 and 90 DAP significantly reduced disease incidence of turmeric leaf blotch (16.13%) and enhanced fresh-rhizome yield (18.30t ha-1) compared to other fungicide applications. High cost-benefit ratio was achieved with rhizome treatment, followed by foliar application of Carbendazim + Mancozeb at 45 and 90 DAP (1:1.92)

Managing Service-Heterogeneity using Osmotic Computing

Computational resource provisioning that is closer to a user is becoming increasingly important, with a rise in the number of devices making continuous service requests and with the significant recent take up of latency-sensitive applications, such as streaming and real-time data processing. Fog computing provides a solution to such types of applications by bridging the gap between the user and public/private cloud infrastructure via the inclusion of a "fog" layer. Such approach is capable of reducing the overall processing latency, but the issues of redundancy, cost-effectiveness in utilizing such computing infrastructure and handling services on the basis of a difference in their characteristics remain. This difference in characteristics of services because of variations in the requirement of computational resources and processes is termed as service heterogeneity. A potential solution to these issues is the use of Osmotic Computing -- a recently introduced paradigm that allows division of services on the basis of their resource usage, based on parameters such as energy, load, processing time on a data center vs. a network edge resource. Service provisioning can then be divided across different layers of a computational infrastructure, from edge devices, in-transit nodes, and a data center, and supported through an Osmotic software layer. In this paper, a fitness-based Osmosis algorithm is proposed to provide support for osmotic computing by making more effective use of existing Fog server resources. The proposed approach is capable of efficiently distributing and allocating services by following the principle of osmosis. The results are presented using numerical simulations demonstrating gains in terms of lower allocation time and a higher probability of services being handled with high resource utilization.Comment: 7 pages, 4 Figures, International Conference on Communication, Management and Information Technology (ICCMIT 2017), At Warsaw, Poland, 3-5 April 2017, http://www.iccmit.net/ (Best Paper Award

Critical success factors for implementation of supply chain management in Indian small and medium enterprises and their impact on performance

AbstractGlobalization of the economy, e-business, and introduction of new technologies pose new challenges to all organizations especially for small and medium enterprises (SMEs). In this scenario, successful implementation of supply chain management (SCM) can give SMEs an edge over their competitors. However, SMEs in India and other developing countries face problems in SCM implementation due to lack of resources and direction. Against this backdrop, this paper identified 13 critical success factors (CSFs) for implementation of SCM in SMEs and studied their impact on performance of Indian SMEs. Top management commitment, long–term vision, focus on core strengths, devoted resources for supply chain, and development of effective SCM strategy emerged as the most pertinent CSFs. To measure improvement in performance, the authors considered different measures related to customer service and satisfaction, innovation and growth, financial performance, and internal business. Results are analysed by testing research propositions using standard statistical tools

Morphology of the Esophageal Hiatus: Is It Different in 3 Types of Hiatus Hernias?

Background/aimsThe esophageal hiatus is formed by the right crus of the diaphragm in the majority of subjects. Contraction of the hiatus exerts a sphincter-like action on the lower esophageal sphincter (LES). The aim is to study the hiatal anatomy (using CT scan imaging) and function (using high-resolution manometry [HRM]), and esophageal motor function in patients with sliding and paraesophageal hiatal hernia.MethodsWe assessed normal subjects (n = 20), patients with sliding type 1 hernia (n = 18), paraesophageal type 2 hernia (n = 19), and mixed type 3 hernia (n = 19). Hernia diagnosis was confirmed on the upper gastrointestinal series. The hiatal morphology was constructed from the CT scan images. The LES pressure and relaxation, percent peristalsis, bolus pressure, and hiatal squeeze pressure were assessed by HRM.ResultsThe CT images revealed that the esophageal hiatus is formed by the right crus of the diaphragm in all normal subjects and 86% of hernia patients. The hiatus is elliptical in shape with a surface area of 1037 mm2 in normal subjects. The hiatal dimensions were larger in patients compared to normal subjects. The HRM revealed impaired LES relaxation and higher bolus pressure in patients with paraesophageal compared to the sliding hernia. The hiatal pinch on HRM was recognized in significantly higher number of patients with sliding as compared to paraesophageal hernia.ConclusionsUsing a novel approach, we provide details of the esophageal hiatus in patients with various kinds of hiatal hernia. Impaired LES relaxation in paraesophageal hernia may play a role in its pathophysiology and genesis of symptoms

Systemic Review: Sexual Dysfunction in Women with type 2 Diabetes Mellitus

Diabetes would not just have a high blood glucose level in the individual body, yet these days diabetes likewise goes with numerous other organic issues like hypertension, feeble the myocardial layer working, sexual broke, and so on. These are some real issue which is these days joined by diabetes to a person’s body. Guys are for the most part being determined to have the sexual broke issue, guys, as well as experience a sexual broke issue. As similarly we may see less clinical examinations, including sexual broke issues looked for the sort two diabetic ladies. The primary goal of this article is to illuminate the situation that females proceed with much trouble with regards to the sexual broke Complication that might be physiological or neurotic if there should arise an occurrence of sorting two diabetes in ladies. It chiefly involves the useful extent of females like sexual drive, excitement, vaginal grease, Orgasm and general fulfilment space. Talking about the treatmentaccess of the ailment in the analyti way for it, Diabetes essentially hinders the sexual execution of Diabetic Women. Determinants of sexual ability incorporate age and extent of diabetes

Enhanced α1 Microglobulin Secretion from Hepatitis E Virus ORF3-expressing Human Hepatoma Cells Is Mediated by the Tumor Susceptibility Gene 101

Viruses are known to exploit the host cell machinery for their benefit during different stages of their life cycle within the infected host. One of the major challenges for a virus during the early stages of infection is to escape recognition by the host immune system. Viruses have adopted many novel strategies to evade the host immune response or to create an immune suppressed environment. An earlier study in our laboratory has demonstrated that the ORF3 protein of the hepatitis E virus expedites the secretion of alpha1 microglobulin, an immunosuppressant molecule. Based on this observation, we proposed that enhanced secretion of alpha1 microglobulin may help maintain an immunosuppressed milieu around the infected hepatocyte (Tyagi, S., Surjit, M., Roy, A. K., Jameel, S., and Lal, S. K. (2004) J. Biol. Chem. 279, 29308-29319). In the present study, we discovered that the ability of the ORF3 protein to expedite alpha1 microglobulin secretion is attributed to the PSAP motif present at the C terminus of the former. The ORF3 protein was able to associate with the tumor susceptibility gene 101 (TSG101) through the PSAP motif. Further, a PSAP motif-mutated ORF3 protein was unable to associate with TSG101 and also lost its ability to enhance the secretion of alpha1 microglobulin. In addition, the ORF3 protein was found to associate simultaneously with TSG101 and alpha1 microglobulin because all three of them were co-precipitated as a ternary complex. Finally, a dominant negative mutant of the VPS4 protein was shown to block the enhanced alpha1 microglobulin secretion in ORF3-expressing hepatocytes. These results suggest a mechanism by which the ORF3 protein exploits the endosomal sorting machinery to enhance the secretion of an immunosuppressant molecule (alpha1 microglobulin) from the cultured hepatocytes

Phytosociology and species diversity in the catchment of Ratle hydro-electric project, District Kishtwar –J&K (India)

This study deals with the phytosociology and plant diversity in the 10 km radius influence zone of Ratle hydro-electric catchment area in district Kishtwar (J&K). Quadrats of varying sizes were laid to record the parameters like frequency, density, abundance and IVI for trees, shrubs and herbs. The data obtained was further computed to analyse the species diversity using Shannon- Wiener’s index. The results revealed the dominance of Quercus baloot, Vitex negundo and Viola pilosa for trees, shrubs and herbs, respectively. The computation of diversity index showed that species richness and evenness remained relatively lower for trees and shrubby flora whereas relatively higher in case of herbaceous vegetation.