Peripheral Ossifying Fibroma

Peripheral ossifying fibroma is a relatively uncommon gingival growth that is considered to be reactive in nature and postulated to appear secondary to irritation or trauma. They usually occur in young adults with a female predominance and are solitary in nature. We report a case of peripheral ossifying fibroma in a 55-year old femal

Characterization of High Porous PZT Piezoelectric Ceramics by different Techniques

Ultimate properties of a porous ceramic is highly process dependent. In this study, prevalent porous ceramics fabrication methods (Freeze casting, Foam reticulation and Burnable Plastic Sphere (BURPS) method) have been compared by fabricating the porous lead zirconate titanate (PZT) based piezoelectric ceramics. Field Emission Scanning electron microscopy (FESEM) studies were carried out to study the pore size and distribution of the ceramics. Hydrostatic co-efficients increased tremendously on incorporation of porosity which led to Hydrostatic Figure of Merit of 7480 in Foam reticulation samples (porosity 86%). The three dimensionally interconnected networks in the freeze casted samples led to lowest acoustic impedance (6 MRayls) despite not having the lowest density

Design and Implementation of Swarm Robotics for Load Controlling Applications

The present era, where technology is making its way to the zenith, there is no requirement for human to do every small aspect that helps him support this survival. There is no requirement for humans the lift heavy loads and to meet up their consequences such as backbone injuries etc..,. It is these small functionalities that can be done by the extra-terrestrials namely Robots. Swarm Robots is a developing technology. The word “Swarm” refers to working as a group. We have four robots in which there is a master and three other robots. The robots are generally classified into two namely i) Explorer Robots and ii) Carrier Robots. The explorer robots first traverse through the entire path from the source to the destination. They send the information about the terrain to the carrier robots and they act accordingly. Thus the slave works according to the commands of the master. They are designed in such a way to undergo location even on rough terrains. Thus the tasks get accomplished easily in a much more effective way. particular object. So this increases the security along with reducing the burden

EXPERIMENTAL EVALUATION OF ANTIDEPRESSANT ACTIVITY OF AQUEOUS AND CHLOROFORM LEAF AND SHOOT EXTRACTS OF EICCHORNIA CRASSIPES LINN IN MICE

Objective: To investigate antidepressant activity of aqueous and chloroform extract of Eicchornia crassipes plant leaves and shoots in mice.Methods: The antidepressant activity of aqueous and chloroform extract of Eicchornia crassipes plant leaves and shoots were tested by forced swimtest (FST) and tail suspension test (TST) in albino mice and the results were compared for the both extracts. Imipramine was used as the standardrug for comparison. Results: Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, saponins, amino acids, gums and mucilage.aqueous extract of Eicchornea crassipes (AEEC) and chloroform extract of E. crassipes (CEEC) did not produce any lethal effect even upto 2000 mg/kp.o during acute oral toxicity study. In FST and TST, CEEC showed diminution of duration of immobility time in 200 mg/kg but not in 100 mg/kg. Conclusion: From the above finding concluding that, shortening of immobility time in the FST and TST indicating, CEEC showed more antidepressantactivity acting either by the enhancement of central 5-HT or catecholamine neurotransmission compared to AEEC in mice.Keywords: Eicchornia crassipes, Aqueous extract of Eicchornia crassipes, Chloroform extract of Eicchornia crassipes, Forced swim test,Tail suspension test

OPTIMIZATION AND CHARACTERIZATION OF CHITOSAN-BASED NANOPARTICLES CONTAINING METHYLPREDNISOLONE USING BOX-BEHNKEN DESIGN FOR THE TREATMENT OF CROHN’S DISEASE

Objective: The present research was designed to produce methylprednisolone containing chitosan-based nanoparticles using Box-Behnken Design (BBD) and Response Surface Methodology (RSM) for optimization. Methods: Nanostructures were prepared using the ionic gelation method with screened process parameters. According to the design, methylprednisolone chitosan-based nanoparticles (MCSNPs) were optimized using factors like methylprednisolone concentration, stirring speed and temperature whereas particle size, zeta potential and % encapsulation efficiency as responses. From the observed values of responses with confirmation location and desirability, the predicted values were very close to the observed values. Results: Observed values for the optimized formulation have a particle size of 243±2.33 nm with an encapsulation efficiency of 79.3±7.2%. Morphology of the particles using scanning electron microscopy reveals nearly spherical shaped particles. Methylprednisolone was released in vitro in a sustained manner for about 24 h in simulated colonic fluid pH 7, pH 7.8 (Fasted state) and phosphate buffer pH 7.4, when compared to simulated colonic fluid at pH 6 (Fed state). Optimized MCSNPs followed Korsmeyer peppas kinetics with drug release mechanism as anomalous transport. Conclusion: Application of Box-Behnken design and Response Surface Methodology using Design Expert software was successfully used in the optimization of methylprednisolone loaded chitosan-based nanoparticles with high encapsulation efficiency

DEVELOPMENT AND VALIDATION OF A DISSOLUTION METHOD FOR FROVATRIPTAN TABLETS BY REVERSED PHASE UPLC

Objective: The main objective of the method was to develop a simple, rapid, efficient and reproducible, stability indicating reverse phase ultra performance liquid chromatography (RP-UPLC) method for the estimation of frovatriptan in tablet dosage form.Methods: The RP-UPLC method for estimation of frovatriptan (FRT) in their tablets was carried out on Acquity UPLCTM, BEH C-18 (100 × 2.1 mm, 1.7 µm) column using 0.1% trifluroacetic acid buffer and a mixture of methanol and acetonitrile (50:50) using isocratic program. The flow rate of the mobile phase was 0.2 mL min-1and detection wavelength was carried out at 244 nm. Total runtime is 3 minutes for chromatographic run. The method was validated in terms of specificity, linearity, accuracy, precision and robustness as per ICH guidelines.Results: The method was found to be linear in the range of 1.41-3.67 μg mL-1. Recovery was found to be in the range of 97.8-101.8%. Relative standard deviation for precision and intermediate precision was found to be less than 3%. The developed method was successfully applied for the estimation of frovatriptan in tablet formulation and average dissolution rate was found to be 93%. The results obtained from the validation experiments prove that the developed method is suitable for routine analysis.Conclusion: The developed RP-UPLC method was simple, rapid, accurate, and precise for the estimation of dissolution rate in frovatriptan tablet dosage form.Â

Utilisation of High Energy Propellant Waste in Manufacturing of Fired Clay Bricks to Enhance the Acoustic Properties

The disposal and waste management of solid high energy propellant (HEP) is a considerate conservational problem. HEP waste is currently disposed in open or confined burning which may cause environmental hazards. In this paper, we examined and discussed results on recycling of HEP waste into fired clay bricks baked in different orientation. HEP modified bricks with 1.5%, 3% and 5 wt. % HEP waste content were manufactured and tested, and then compared against virgin clay bricks without HEP content. The effect of directional orientation of bricks baked with varying HEP content on acoustic properties were experimented and discussed. The sound transmission loss decreases with increase in HEP waste due to formation of independently closed directional pores. The transmission loss of horizontally baked during firing of bricks is nearly 5dB lower than vertically baked bricks. Results of the experimental studies indicate that HEP waste can be utilised in fired clay bricks and different orientation baking further enhances the acoustic properties

A review on the genus Calophyllum (Clusiaceae): a potential medicinal tree species

Calophyllum is the genus of evergreen tropical flowering plants in the Clusiaceae family. They are predominantly located in Asia with some of its genus distributed in the Pacific Islands, Americas, Australasia and Africa. Plants of the genus are well known for their chemical properties with lots of secondary metabolites such as triterpenes, flavonoids, coumarins and xanthones. Compounds from Calophyllum have been reported to have cytoprotective, anti-HIV, anti-secretory, cytotoxic, antinociceptive, molluscicidal and antimicrobial properties. Some of the plants in Calophyllum are used in folk medicine to treat conditions like peptic ulcers, tumours, inflammation, infections and pain. Calophyllum genus is important with respect to their ecological as well as their medicinal properties. But in India, some species located in Western Ghats are in vulnerable stage. Even so, there is no remarkable studies carried out about this genus. So, for a sustainable environment, we should focus on the conservation, restoration and rehabilitation of the genus that makes huge differences in their population. This article reviews the genus Calophyllum of Western Ghats as a potential medicinal tree species