Effective fracture geometry obtained with large water sand ratio

Shale gas formation exhibits some unusual reservoir characteristics: nano-darcy matrix permeability, presence of natural fractures and gas storage on the matrix surface that makes it unique in many ways. It’s difficult to design an optimum fracture treatment for such formation and even more difficult is to describe production behavior using a reservoir model. So far homogeneous, two wing fracture, and natural fracture models have been used for this purpose without much success. Micro seismic mapping technique is used to measure the fracture propagation in real time. This measurement in naturally fractured shale formation suggests a growth of fracture network instead of a traditional two wing fractures. There is an industry wise consensus that fracture network plays an important role in determining the well productivity of such formations. A well with high density of fracture networks supposed to have better productivity. Shale formations have also exhibited production pattern which is very different from conventional or tight gas reservoir. Initial flow period is marked by steep decline in production while the late time production exhibits a slow decline. One of the arguments put for this behavior is linear flow from a bi-wing fractured well at early time and contribution of adsorbed gas in production at late time. However, bi-wing fracture geometry is not supported by the micro-seismic observation. A realistic model should include both the fracture network and adsorbed gas property. In this research we have proposed a new Power Law Permability model to simulate fluid flow from hydraulically fractured Shale formation. This model was first described by Valko & Fnu (2002) and used for analyzing acid treatment jobs. The key idea of this model is to use a power law permeability function that varies with the radial distance from well bore. Scaling exponent of this power law function has been named power law index. The permeability function has also been termed as secondary permeability. This work introduces the method of Laplace solution to solve the problem of transient and pseudo steady-state flow in a fracture network. Development and validation of this method and its extension to predict the pressure (and production) behaviour of fracture network were made using a novel technic. Pressure solution was then combined with material balance through productivity index to make production forecast. Reservoir rock volume affected by the fracture stimulation treatment that contributes in the production is called effective stimulated volume. This represents the extent of fracture network in this case. Barnett shale formation is a naturally fractured shale reservoir in Fort Worth basin. Several production wells from this formation was analysed using Power Law Model and it was found that wells productivity are highly dependent on stimulated volume. Apparently the wells flow under pseudo steady state for most part of their producing life and the effect of boundary on production is evident in as soon as one months of production. Due to short period of transient flow production from Barnett formations is expected to be largely independent of the relative distribution of permeability and highly dependent on the stimulated area and induced secondary permeability. However, an indirect relationship between permeability distribution and production rate is observed. A well with low power law index shows a better (more even) secondary permeability distribution in spatial direction, larger stimulated volume and better production. A comparative analysis between the new model and traditional fracture model was made. It was found that both models can be used successfully for history matching and production forecasting from hydraulically fractured shale gas formation

Project success and critical success factors of construction projects: project practitioners’ perspectives

Project management is primarily practitioneroriented and loaded with many critical success factors (CSFs), and although these are well-evidenced in theory, they do not deliver as efficiently as factors of interest to project professionals during execution. The present study explores the perceptions of senior project managers (PMs) about project success, CSFs and complexity in large construction projects. Data from project practitioners were collected through semi-structured interviews and analysed using content analysis. The participants were selected with convenience sampling method given the complex understanding of the domain and included highly experienced PMs from the global community with expertise in project management. PMs perceive a small number of CSFs in contrast to the large exhaustive CSFs listed in the questionnaire surveys. Though important, traditional constraints of the Iron Triangle are considered inadequate in defining project success. Project professionals are seen as relying more on other performance indicators for defining a project as a success. They perceive complex construction projects in terms of a large number of interfaces, complex working systems and uncertainty. The findings of this paper suggest that project practitioners perceive differently about the CSFs and project success

Efficacy and safety of topical 2% dorzolamide and 0.5% timolol in cases of open angle glaucoma in a tertiary care hospital of East Singhbhum: an observational, prospective and comparative study

Background: Present study was undertaken to evaluate and compare the efficacy and side effects of 2% dorzolamide and 0.5% timolol in patients with open angle glaucoma.Methods: There were 60 randomly selected patients were equally divided into Group I (n=30) and Group II (n=30). Further both groups were divided into IA (n=10), IB (n=20), IIA (n=10) and IIB (n=20). 2% Dorzolamide hydrochloride in Group IA and IIA and 0.5% Timolol maleate in Group IB and IIB was administered for 24 weeks. Patients were evaluated for general and ocular examinations on day of enrolment and then at the end of 1st, 4th, 8th and 24th week. Adverse effects of the drug during study period were also noted. Mean±SD, t value, p value and comparison between groups were analysed by graph pad software.Results: At the end of 24 weeks difference in mean reduction of IOP was not significant with 6.2±1.85mm Hg (Right eye) and 5.55±1.68mm Hg (left eye) and 4.72±2.97mm Hg (Right eye) and 5.37±1.24mm Hg (left eye) in Group IA and Group IIA respectively. At the end of 24 weeks difference in mean reduction of IOP was not significant with 5.06±1.62mm Hg (Right eye) and 4.40±1.96mm Hg (left eye) and 4.30±1.41mm Hg (Right eye) and 4.12±2.08mm Hg (left eye) in Group IB and Group IIB respectively. Fall in both systolic and diastolic blood pressure in both the groups were significant. Both drug regimens were well-tolerated, and no serious drug-related adverse effects were reported.Conclusions: Dorzolamide was more efficacious for reduction of intra ocular pressure, well-tolerated, had low allergic response and had a favourable ocular, cardiovascular and respiratory safety profile than Timolol.

Herbal or modern methods of contraception! choice is yours

Contraception generally means prevention of pregnancy. There are a variety of methods ranging from natural to scientific available in accordance to its nature of use. Some methods provide short term birth control facility whereas some other provides permanent or long term birth control facility. But all the methods have some advantages and disadvantages associated with them. For example, male condoms which is made of latex, is 97% effective if used properly though some people may have allergic reaction to latex. Oral contraceptives are also widely used but it causes heart attacks, cancer, and depression among pills user women. Herbal contraception offer alternate ways for women to avoid pregnancy and it is also free from any side effects but the reliability of herbal contraceptive remains uncertain

Study of self drug administration among second professional medical students

Background: Self-medication is very common in our day to day life which is an unhealthy and risky practice. Present study was done to determine the knowledge, attitude and practice among second professional medical students.Methods: A questionnaire related to self-medication with consent was prepared and distributed among the students of second professional. Data was collected and analysed the results expressed as counts and percentages.Results: Total 100 students participated in the study for taking self-medication and was no need to visit the doctor for minor illness. In maximum students, source of information of the drugs used for self-medication pharmacological based and learning process in the college. The source of drug was medical store. Most of the students took self-medication for loose motion and headache followed by cough, cold and fever. Out of total 100 students most of the students took paracetamol tablet as self-medication.Conclusions: This study showed that second professional medical students after studying pharmacological books they do not use any wrong medicine as self-medication. High level of awareness of second professional students has minimized self medication

Comparing the number of attempts required for complete nuclear chop using calibrated and conventional phacotip

Background: Phacoemulsification is a state of art technique with a steep learning curve the configuration of the phacotip affects the efficacy and execution of the nuclear chopping techniques. Inadequate penetration of phacotip may result in partial thickness nuclear cleavage with residual posterior plane and over enthusiastic penetration may result in posterior capsule rupture. This may be avoided if some estimate can be made preoperatively of the depth of penetration required to achieve full thickness crack.Methods: A total of 60 eyes of 60 patients with age related cataract with grade 4.0 to 6.9 (LOCS III) fulfilling the inclusion and exclusion criteria were included in the study after written informed consent. They were divided into two groups A and B with 30 patients each randomly using envelope method and were operated using conventional and calibrated phacotips respectively and the number of attempts required to achieve complete nuclear chop was noted.Results: In group A, vertical chop was safely and effectively done is 23 patients in just one attempt while it took 2 attempts in 6 patients and 3 attempts in 1 patient. In group B, it took just one attempt in 26 patients while 2 attempts were required in 4 patients. The two groups were comparable (p value 0.453) and was found to be statistically significant.Conclusions: With the use of a calibrated phacotip, the surgeon already knows to what depth he has to penetrate the tip into the center of nucleus depending upon the grade of cataract which results in safe and effective chop in minimum attempts where as in the conventional phacotip, it is more of a blind process. Hence the calibrated phacotip has taken the guess work out of question

Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models

<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide that is particularly refractory to chemotherapy. Several studies have proposed combination chemotherapy regimen for HCC treatment. However, these therapies are not effective in regressing tumor and prolonging survival of patient's suffering from HCC. Therefore, the development of more effective therapeutic tools and new strategies for the treatment of HCC are urgently needed. Over the last decade much attention has been focused on "bystander effect" as a possible therapeutic strategy for the treatment of certain human tumors. Interest in this therapeutic approach originated from numerous reports describing the radiation induced bystander effect. However, the knowledge about chemotherapy induced bystander effect is still limited. Hence, chemotherapy induced bystander phenomenon in hepatoma cells was explored by utilizing Mitomycin C (MMC).</p> <p>Results</p> <p>MMC induced bystander killing was observed only in hepatoma cells and it did not occur in cervical cancer cells. MMC induced bystander killing was transferable via medium. It occurred in co-cultured cells indicating the involvement of secreted as well as membrane bound factors. FasL and TRAIL were detected in the conditioned medium from treated cells. In medium transfer experiment, pre-treatment with EDTA (a broad range protease inhibitor) diminished MMC induced bystander killing. Following drug exposure, expression of Fas and TRAIL receptors increased and treatment with neutralizing antibodies against FasL and TRAIL inhibited bystander killing.</p> <p>Conclusion</p> <p>Our results highlight the therapeutic importance of MMC in the treatment of HCC and implicate role of membrane bound and secreted forms of FasL and TRAIL in MMC induced bystander killing.</p

Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS

The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system

Liver Assist Devices for Liver Failure

Historically, mortality rates for liver failure have been high, regardless of the type. With new advancements in liver transplantation (LTx), 1-year survival rates have improved up to 95% in most recent estimates. While some patients may live past the critical period, the majority of patients do not survive the interval period for awaiting LTx or liver regeneration. The function of the liver to detoxify and correct several biochemical parameters has been achieved to some extent through artificial liver support technology, although constant innovations are still being developed for the most optimal liver support device. The complex function of the liver makes it challenging since it does not only detoxify toxic by-products but also participates in numerous other synthetic and metabolic functions of the body. Liver support systems are divided into an artificial liver assist device (ALD) and a bioartificial liver assist device (BLD). ALDs include molecular adsorbent recirculating system (MARS), Prometheus, single-pass albumin dialysis, and selective plasma filtration therapy. These devices work as a blood purification system of the liver. On the other hand, BLD has hepatic cell lines incorporated in its equipment, which aims to function as a complex biological liver system providing support to its biochemical processes. Several clinical and randomized trials have conflicting results on the survival of the patients with acute liver failure (ALF), and the ideal liver support system still seems a far-off goal

Incidence of diabetes and ischemic heart disease in COVID-19 post pandemic

Background: The long-term effects of COVID-19 pandemic are currently getting more attention. The majority of individuals with COVID-19 report having symptoms for longer than 4 weeks following their initial appearance. after COVID-19 infection, there is worry that cardiovascular conditions and metabolic conditions may be harmed. Aim of the study the incidence of ischaemic heart disease and diabetes mellitus (DM) post COVID 19 pandemic. Methods: Information for all individuals diagnosed as suffering of COVID-19 were taken at the beginning of the investigation from the health department's release of electronic medical records in February 2021. The main outcomes analysed were first ever documented cardiovascular disorders (CVD) as well as DM diagnoses. The data were then combined for the time periods following the index date (long COVID-19), for five to twelve weeks following the index date (post-acute COVID19), for four weeks after the date of indexing (acute COVID-19), prior to the index date (Pre-index). For COVID-19 patients as well as control subjects, incidence rates with precise Poisson confidence intervals (CIs) were computed. Results: CVD events was 1362 in COVID-19 study group while it was 131 in control study group at phase corresponding to four weeks after the indexed date. CVD events was 781 in COVID-19 study group while it was 298 in control study group at phase corresponding to five to twelve weeks since the date of indexing. CVD events was 781 in COVID-19 study group while it was 298 in control study group at phase corresponding to five to twelve weeks since the date of indexing. CVD events was 2,134 in COVID-19 study group while it was 298 in control study group at phase corresponding to 13 to 52 weeks since the date of indexing.   Conclusions: Early on after COVID-19 infection, the risk of CVD is elevated, and this risk is elevated for up to three months. However, there does not appear to be a long-term rise in the prevalence of CVD or DM in COVID-19 patients who do not already have these illnesses. This study shows that after COVID-19 infection, the incidence of DM is high for at minimum 12 weeks before it starts to decline