SUN PROTECTIVE POTENTIAL OF POLYHERBAL SKIN CARE CREAM

Objective: Evaluation of sun protective potential of polyherbal skin care cream Methods: In vitro sun protection factor of polyherbal cream of Centella asiatica, Azadirachta indica, Ocimum sanctum and Hibiscus rosa sinensis was determined by spectrophotometric method using UV visible spectrophotometer. Results: The formulation F4 was found most satisfactory in all parameter evaluated with good sun protection potential, so it could be used as effective sun protective agent. Conclusion: Herbal cosmetics were recognised as a safe, better and effective alternative of synthetic cosmetics that could help to protect and promote skin health naturally without any side effects. The herbal cream F4 was found good sun protection potential against the damaging effects of UV radiations

Modeling and Simulation of Multi-tier Enterprise IT System

This paper discusses modelling and simulation of multi-tier enterprise IT system. The layers in multi-tier architecture consist of web layer, application layer and database layer. Entities in the multi-tier system have been abstracted out into 3 categories- consumer, resource and router. Existing modelling and simulation frameworks for multi-tier systems focus on power management or performance of load balancing algorithms. Our framework enables seamless modelling, simulation, and experimentation of a wide range of what-if scenarios in multi-tier systems while encapsulating all the variations that arise due to configuration, composition, design and deployment. As an illustration, we discuss and simulate prediction of bottleneck scenario with results

Properties of Waste Polyethylene Terephthalate (PET) Modified Asphalt Mixes: Dependence on PET Size, PET Content, and Mixing Process

Management and disposal of waste polyethylene terephthalate (PET) bottles is an ever-growing challenge. The present study investigated the effect of incorporation of shredded waste PET bottles on properties of asphalt mixes in terms of: (i) process of PET addition, (ii) PET content, and (iii) PET size. Experimental design included three variables: two processes (dry process, and modified dry process), three PET contents (2.5%, 5.0%, and 7.5% by weight of binder), and two PET sizes (2.36–1.18 mm, and 0.30–0.15 mm). Volumetric properties, Marshall parameters, and moisture susceptibility characteristics of PET modified mixes were evaluated and compared with control mix (without PET). Analysis of variance (ANOVA) was performed to evaluate main and interaction effects of the variables. Results indicated that all the three variables had significant influence on the measured properties. Further, mixes prepared using modified dry process outperformed other mixes and showed highest resistance towards moisture induced damage

Governance Policies in IT Service Support

IT Service support provider, whether outsourced or kept in-house, has to abide by the Service Level Agreements (SLA) that are derived from the business needs. At the heart of IT Service support provider are the human resources that are expected to resolve tickets. It is essential that the policies, which govern the tickets’ movement amongst these resources, follow the business objectives such as service availability and cost reduction. In this study, we propose an agent based model that represents an IT Service Support system. A vital component in the model is the agent ‘Governor’, which makes policy decisions based on the by reacting to changes in the environment. The paper also studies the impact of various behavioural attributes of the Governor on the service objectives

Sales Management Portal

The use of the Web (World Wide Web) has had many positive effects on E commerce. It overcomes time and space limitations from traditional marketing. Consumer and customer are now using the Web to access vast amounts of information and resources in the cyberspace. Also, marketing via the Web enables both synchronous and asynchronous communication. Despite of many benefits of the Web. The model can also enhance the business of GSU Corporation is a world-renown provider of communication solutions. We implement our model and show that it can be applied for scales management as an instance. The Sales Management portal is web based application where the users will be able to make purchases of different sales based products available at the store. The web based application will be having three levels of access where each user will be having different menu options available for performing various levels tasks based on the level of authorization. The web based application will be dealing with the selling of the on-line based products and generating the sales information to create plans and deals for the future to gain more profits. The importance of the project lies in the generation of the sales data by which the vendors or the sellers can gain knowledge about the products and the likeliness to buy the product

Evaluation of bio-asphalt binders modified with biochar: a pyrolysis by-product of Mesua ferrea seed cover waste

With growing global concerns related to energy security and sustainability, interest in bio-fuels has increased significantly. Production of biofuel mostly begins with pyrolysis, a process that converts the biomass to liquid biooil, solid biochar and gases. A large amount of carbonaceous biochar is generated as a by-product during the pyrolysis. However, no major effort has been made in the past decade to utilize the biochar in pavement applications, especially as a bio-modifier to asphalt binders. In this study, an attempt was made to evaluate the carbonaceous biochar, obtained during bio-fuel production through pyrolysis of Mesua ferrea seed cover waste, as an asphalt modifier/extender to obtain bio-asphalts. Physical and chemical characterizations of biochar were carried out using scanning electron microscopy, Fourier transform infrared spectroscopy and energy dispersive X-ray analysis. This was followed by rheological characterization of asphalt binders (from two sources) modified with various concentrations of biochar (0, 5, 10, 15, and 20% by weight of binder). Flow behaviour, permanent deformation, and fatigue characteristics of bio-asphalts were evaluated and compared with control binders (no biochar). Aging susceptibility of biochar modified binders was also evaluated and compared for biochar contents and binder sources. Permanent deformation behaviour evaluated through multiple stress creep and recovery (MSCR) test indicated that the use of biochar improved the rutting resistance of binders. Improved binder performance against the effects of aging and deformation with the use of biochar makes it a promising asphalt modifier, especially for the warm tropical climatic conditions prevalent in India

A prospective observational study on incidence of adverse drug reactions in a tertiary care teaching hospital: a pharmacovigilance study

Background: An adverse drug reaction (ADRs) is determined as response to a drug that is noxious unintended excludes therapeutic failures, overdose, drug abuse, noncompliance, and medication errors. The main aim of the study is to detect, understand and report ADR’S.Methods: This study is prospective observational study conducted for 6 months in in-patient setting in a tertiary care hospital. Naranjo’s, WHO causality scale, Siegel scale, Schumock and Thornton scale are used to assess ADR. Graph Pad Prism and SAS software’s are used.Results: Data was collected from a total of 1000 patients of which 121 (12.1%) patients were effected with 150 ADRs. Among 121 patients AdrAd was 60.66% and AdrIn was 39.33%. Of 121 patients 97 patients with single ADR, 28 patients with 2 ADRs, 10 patients were with three ADRs. ADR onset divides acute (10%), Latent (39%) and sub-acute (51%). ADR occurred are recovered (54%), Recovering (13%). Naranjos scale interprets definite (0.9%), probable (50.9%), possible (42.97%). According to WHO scale certain (2.7%), unlikely (2.7%), possible (38.84%). Hartwig and Siegel scale results are mild (12.4%), moderate (66.12%) and severe (12.4%). Schumock and Thornton preventability results are definitely (25.45%), probably (68.18%) and not preventable (6.36%).Conclusions: Every health care professional should be aware of the Pharmacovigilance principles and also should be aware of suspected ADR reporting form of PVPI. By applying the above scales it is easy for health care professionals to assess an ADR

Classification and applying pharmacovigilance principles to study adverse drug reaction and its management

Adverse drug reaction (ADR) is an unwanted, undesirable effect of medication resulting in mild to severe effect on the patient. This review explains definitions of ADR and it differentiation with adverse drug event, medication error. ADRs may cause increased length of stay or initial reason for admission and are major cause of morbidity and mortality worldwide. Risk factors for ADR occurrence include age, gender, patients with multiple diseases and multiple drug therapy (polypharmacy). ADRs are classified into different types based on the mechanism and onset of reaction. The causal relation between suspected drug and reaction can be assessed by using causality assessment scales. The severity and preventability of ADR can be assessed by severity assessment scale and preventability scale respectively. Clinical Pharmacists play an important role in monitoring and management of ADRs

Recent advancements in surface modification, characterization and functionalization for enhancing the biocompatibility and corrosion resistance of biomedical implants

Metallic materials are among the most crucial engineering materials widely utilized as biomaterials owing to their significant thermal conductivity, mechanical characteristics, and biocompatibility. Although these metallic biomedical implants, such as stainless steel, gold, silver, dental amalgams, Co-Cr, and Ti alloys, are generally used for bone tissue regeneration and repairing bodily tissue, the need for innovative technologies is required owing to the sensitivity of medical applications and to avoid any potential harmful reactions, thereby improving the implant to bone integration and prohibiting infection lea by corrosion and excessive stress. Taking this into consideration, several research and developments in biomaterial surface modification are geared toward resolving these issues in bone-related medical therapies/implants offering a substantial influence on cell adherence, increasing the longevity of the implant and rejuvenation along with the expansion in cell and molecular biology expertise. The primary objective of this review is to reaffirm the significance of surface modification of biomedical implants by enlightening numerous significant physical surface modifications, including ultrasonic nanocrystal surface modification, thermal spraying, ion implantation, glow discharge plasma, electrophoretic deposition, and physical vapor deposition. Furthermore, we also focused on the characteristics of some commonly used biomedical alloys, such as stainless steel, Co-Cr, and Ti alloys

Unraveling the corrosion inhibition behavior of prinivil drug on mild steel in 1M HCl corrosive solution: insights from density functional theory, molecular dynamics, and experimental approaches

The deterioration of mild steel in an acidic environment poses a significant challenge in various industries. The emergence of effective corrosion inhibitors has drawn attention to studies aimed at reducing the harmful consequences of corrosion. In this study, the corrosion inhibition efficiency of Prinivil in a 1M HCl solution through various electrochemical and gravimetric techniques has been investigated for the first time. The results demonstrated that the inhibition efficiency of Prinivil expanded from 61.37% at 50 ppm to 97.35% at 500 ppm concentration at 298 K. With a regression coefficient (R2) of 0.987, Kads value of 0.935 and Ea value of 43.024 kJ/mol at 500 ppm concentration of inhibitor, a strong affinity of Prinivil for adsorption onto the metal surface has been significantly found. Scanning electron microscopy (SEM) and contact angle measurement analyses further support the inhibitory behavior of Prinivil, demonstrating the production of a defensive layer on the surface of mild steel. Additionally, molecular dynamics (MD) and Monte Carlo simulations were employed to investigate the stability and interactions between Prinivil and the metallic surface (Fe (1 1 0)) at the atomic level. The computed results reveal strong adsorption of Prinivil upon the steel surface, confirming its viability as a corrosion inhibitor