Comparison of sevoflurane and isoflurane effects on cardiovascular and respiratory system during spontaneous ventilation in Angora goats

KUMANDAS, ALI/0000-0002-7679-2126WOS: 000359122700018Seven healthy Angora goats were used to compare the effects of isoflurane and sevoflurane on the cardiovascular and respiratory systems during anesthesia periods. Once anesthesia was induced with propofol at 5.1 +/- 0.9 mg/kg, it was maintained with isoflurane at 1%-3% in the first treatment period and sevoflurane at 2%-4% in the second treatment period after a 15-day interval. Heart rates measured immediately after anesthesia induction and 5 min later were found to be statistically significant between anesthetic groups (P < 0.05). Mean blood pressure in the isoflurane group decreased (75.7 +/- 7.2 to 59.8 +/- 9.8 mmHg) (P < 0.05) throughout the anesthesia period. It was determined that respiratory rate in sevoflurane treatment was lower than that in isoflurane treatment. In terms of time to stand up, sevoflurane-administered animals recovered significantly faster than animals intubated with isoflurane anesthesia (13.1 +/- 4.4 and 25.0 +/- 8.6 min) (P < 0.05). According to cardiopulmonary values, the respiratory rate was lower in the sevoflurane-applied animals compared to that of those receiving isoflurane anesthesia, although the difference was not statistically significant, and hypercapnia were not observed in either group. Consequently, it was determined that in the Angora goat, propofol-sevoflurane anesthesia exerts lower pressure on the cardiovascular system than isoflurane anesthesia. At the same time, recovery from sevoflurane anesthesia was shorter, and therefore it can be preferred to other anesthesia agents for routine anesthesia.Kirikkale University Scientific Research Project Coordination Unit (KUBAP)Kirikkale University [2009/02]This study was supported by the Kirikkale University Scientific Research Project Coordination Unit (KUBAP No: 2009/02)

Iatrogenic epidermoid tumor: Late complication of lumbar puncture

Intraspinal epidermoid tumors can be congenital and acquired. Acquired intraspinal epidermoid tumors are extremely rare. Epidermal elements are implanted into the arachnoid space by trauma, spinal anesthesia, surgery, bullet wounds, myelography, or lumbar puncture. Approximately 40% of acquired epidermoid tumors are considered a late complication of lumbar puncture. The authors report the case of an 8-year-old boy who presented with a 1-year history of back and hip pain and radiating pain to both thighs posterior. Lumbar puncture was performed in the neonatal intensive care unit to rule out meningitis in the patient's past medical history. The patient underwent total surgical excision of the epidermoid tumor. Pathologic examination revealed the diagnosis of epidermoid tumor

Comparison of the Algan Hemostatic Agent with Floseal in Rat Liver Laceration Bleeding Model

Objective: Major vascular injury is one of the most important causes of death after trauma. The effective and speedy control of the hemorrhage is crucial in reducing deaths. Many products are used for this purpose. Today, however, an ideal product has not yet been produced and there is a strong demand for such effective hemostatic products. The aim of this study is to compare the efficacy of Algan hemostatic agent with Floseal in the liver laceration model in rats. Materials and Methods: A total of 28 rats were used in the study. Rats were divided into 4 groups, each consisting of 7 rats. Experimental liver laceration was established. In the control group, saline-impregnated gauze was applied. Algan hemostatic agent-impregnated sponge, Algan hemostatic agent powder, and Floseal gel were applied to the experimental groups. Results: There was no difference in bleeding control among the Algan hemostatic agent powder, Algan hemostatic agent-impregnated sponge, and Floseal. When compared to the control group, Algan hemostatic agent powder, Algan hemostatic agent-impregnated sponge, and Floseal were found to be very effective in bleeding control, respectively (P = .001, .012, and .002), in the experimental groups. Conclusion: This study showed that the properties of both Algan hemostatic agent powder and Algan hemostatic agent-impregnated sponge for controlling bleeding are similar to Floseal. Considering other characteristics such as Algan hemostatic agent’s naturalness, easy applicability, and low cost, Algan hemostatic agent has been a promising effective hemostatic agent

Transient sixth nerve palsies and torticollis secondary to parietal arteriovenous malformation

Arteriovenous malformations (AVMs) can compress on any intracranial structures, and the presence and nature of ophthalmologic symptoms and signs depend on the size and location of the AVMs. We report an 11-month-old girl with parietal fistulous AVM, transient bilateral sixth nerve palsies and torticollis. The postoperative period was uneventful and she was discharged in a good condition. The patient recovered from transient bilateral abducens nerve palsies and torticollis; she was asymptomatic during the 18-month follow-up period. Copyright (c) 2007 S. Karger AG, Basel

The Effects of Ketoprofen and Meloxicam on Bone Healing in Rat Model: A Comparative Dual Energy X-Ray Absorptiometry Study

KUMANDAS, ALI/0000-0002-7679-2126WOS: 000305923500024Pain control is a common clinical approach in trauma and postoperative care especially complicated orthopedic surgeries to ease the deleterious effects of pain. Various kinds of pain killers have been used, and nowadays nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs for pain control purposes. Prostaglandin-endoperoxide synthetase, also commonly called cyclooxygenase (COX), is one of the key enzymes in prostaglandin bio-synthesis. The COX enzymes have subgroups of enzymes, each of which suppresses different inflammatory mediators. These enzymes are involved in different functions, some of which are essential for continuity of physiological processes. Thus, NSAIDs are expected not to cause any change of functions of some enzymes while suppressing others. Among the COX enzymes, COX-1 is associated with gastrointestinal system functions and gastrointestinal mucosa while COX-2 is associated with inflammation and pain. Like most drugs, NSAIDs have known and possible side effects. In various studies related to NSAIDs, inhibitory effects of conventional NSAIDs with non-selective effects and specific COX-2 inhibitors on bone healing have been reported. In this study, the effects of ketoprofen and meloxicam on bone fracture healing induced in 24 adult male Wistar rats was studied by Dual Energy X-Ray Absorptiometry (DEXA). The results indicates that meloxicam inhibits the fracture healing to some degree.Scientific Research Project Coordination Unit of Kirikkale UniversityKirikkale UniversityThis research was supported by the Scientific Research Project Coordination Unit of Kirikkale Universit

Erdheim Chester disease: Cerebral involvement in childhood

Erdheim Chester disease (ECD) is an uncommon, non-Langerhans form of histiocytosis, characterized by long bone sclerosis. To date, only approximately some 100 cases have been reported. The diagnosis is based on its peculiar radiological and pathological features. ECD disease is rarely expected preoperatively. Although the ECD is an adult illness it can rarely be seen in the childhood period. We reported the case of a 10-year-old boy who presented headache, paraparesis and with diabetes inspidus for 6 years. As far as we know. the case presented here is the first published report of intracranial involvement and unilateral bone sclerosis with ECD in childhood. (c) 2006 Elsevier B.V. All rights reserved

Effects of Halothane and Isoflurane Anaesthesia on Antioxidant Enzymes in Dogs

Ince, Sinan/0000-0002-1915-9797; KUMANDAS, ALI/0000-0002-7679-2126;WOS: 000284033700013Free radicals, along with the impairment of biological membranes and cellular structures and increased biological activity, come out with the results of the changes in the activity of the enzymes followed by the damages of cellular function and metabolism This condition was attributed to the initiation effects of anaeshetics and other drugs which are used throughout the general anaesthesia General anaesthesia which is constructed with using many drugs which have various physicochemical structures is a condition affecting lipid peroxidation in the organism directly or indirectly In the frame of the study, the effects of halothane and isoflurane used in the anaesthesia on Malonyldialdehyde (MDA) concentration were investigated The study was carried out on 14 dogs with various breeds, ages and sexes which were admitted to Kirikkale University, Faculty of Veterinary Medicine and with various signs of complaint and determined as healthy according to the clinical and haemotological examination In the experiment, halothane (1-2 5%) and isoflurane (1-3%) were investigated as the anaesthetic substances Diazepam (0 3 mg kg(-1), IM) was administered as preanesthesia and thiopenthal sodium (10 mg kg(-1), IV) was administered for the induction of anesthesia to dogs Halothane and isoflurane were administered to the dogs in the first and second group, respectively The duration of anaesthesia was determined as 60 mm Five blood samples were taken from the animals at the time prior to premedication, immediately before the gas anaesthesia, after 1 h of the initiation of anaesthesia, 3 and 24 h after the end of anaesthesia into the heparinated tubes Malonyldialdehyde levels were measured in plasma During the experimental period, body temperatures, heart rate, respiration rate and blood oxygen saturation values were recorded Malondialdehyde levels measured during the halothane anaesthesia were numerically lower than those determined in isoflurane anaesthesia in same time period However, they reached the same levels prior to the anaesthesia within 24 h m both groups The differences between the two groups were statistically insignificant (p>0 05) Additionally, there were no significant differences in body temperature, heart rate, respiration rate and blood oxygen saturation values between the anaesthethic drugs Results of the comparisons of time and drug type showed that anaesthesia procedures using both halothane and isoflurane did not have any negative effect on the oxidative metabolism in dog

Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats

WOS: 000504656100005The present study was undertaken to evaluate of Nigella sativa oil (NSO) and zinc-silver cream in a rat model of wound healing by means of clinical appearance, histopathology, oxidative stress parameters, and biomechanical tests. The rats were divided into three groups, each having twenty animals. Group 1 served as a control having wound. Other two groups received either NS oil or zinc-silver cream in addition to the wound. The study was initiated after the animals rested for 2 weeks for acclimation. Blood samples were collected from 10 randomly selected animals from each group at days 0, 3, 7 and 14 for oxidative stress measurements. Differences among groups for blood lipid peroxidation and antioxidant values were determined with respect to biochemical oxidative stress results (P<0.01). Wound sites of 10 animals from each group were allocated for histopathological examinations, and those of the remaining 10 animals from each group were used in biomechanical testing._Histopathological examination revealed that epithelization occurred in all groups. Inflammatory response with an intensive vascularization was present in the samples of the silver group (P<0.01). Consequently, zinc-silver group has differed positively in terms of biochemical and biomechanical and histological aspects compared to other groups for wound healing and oxidative stress.Kirikkale University Scientific Research Project Coordination Unit (KUBAP)Kirikkale University [2013 / 80]This study was supported by the Kirikkale University Scientific Research Project Coordination Unit (KUBAP No: 2013 / 80)

Torticollis secondary to posterior fossa and cervical spinal cord tumors: report of five cases and literature review

Torticollis is either congenital or acquired in childhood. Acquired torticollis is not a diagnosis but rather a sign of an underlying disorder. The causes of acquired torticollis include ligamentous, muscular, osseous, ocular, psychiatric, and neurologic disorders and may be a symptom of significant abnormalities of the spinal cord and brain, such as spinal syrinx or central nervous system neoplasia. Torticollis is rarely considered to be an initial clinical presentation of posterior fossa and cervical spinal cord tumors. We report five cases of pediatric tumors with torticollis at the onset: an astrocytoma originating from the medulla oblongata, another presumptive astrocytoma of the spinal cord located between C1 and C6 cervical vertebrae (not operated), an ependymoma located throughout the whole cervical spinal cord extending into the bulbomedullary junction, an astrocytoma originating from the bulbus and extending into the posterior fossa, and another case of a eosinophilic granuloma located extradurally through the anterior and posterior portions of the vertebral bodies from C3 to C7 producing the collapse of the sixth cervical vertebra. All five cases were seen in children, aged between 3 and 12 years. All these cases reflect the misinterpretation of this neurological sign and the lack of association with the possibility of spinal or posterior fossa tumor. This delay in the diagnosis of these diseases led to progressive neurological deterioration and to the increase in the tumor size, which made surgical intervention difficult and the prognosis unfavorable. Although torticollis secondary to tumors is rarely seen, it is necessary to be kept in mind in the differential diagnosis