186 research outputs found
Autocorrelation analysis for the unbiased determination of power-law exponents in single-quantum-dot blinking
We present an unbiased and robust analysis method for power-law blinking
statistics in the photoluminescence of single nano-emitters, allowing us to
extract both the bright- and dark-state power-law exponents from the emitters'
intensity autocorrelation functions. As opposed to the widely-used threshold
method, our technique therefore does not require discriminating the emission
levels of bright and dark states in the experimental intensity timetraces. We
rely on the simultaneous recording of 450 emission timetraces of single
CdSe/CdS core/shell quantum dots at a frame rate of 250 Hz with single photon
sensitivity. Under these conditions, our approach can determine ON and OFF
power-law exponents with a precision of 3% from a comparison to numerical
simulations, even for shot-noise-dominated emission signals with an average
intensity below 1 photon per frame and per quantum dot. These capabilities pave
the way for the unbiased, threshold-free determination of blinking power-law
exponents at the micro-second timescale
Treatment satisfaction and quality-of-life between type 2 diabetes patients initiating long- vs. intermediate-acting basal insulin therapy in combination with oral hypoglycemic agents â a randomized, prospective, crossover, open clinical trial
Within-trial economic evaluation of diabetes-specific cognitive behaviour therapy in patients with type 2 diabetes and subthreshold depression
<p>Abstract</p> <p>Background</p> <p>Despite the high prevalence of subthreshold depression in patients with type 2 diabetes, evidence on cost-effectiveness of different therapy options for these patients is currently lacking.</p> <p>Methods/Design</p> <p>Within-trial economic evaluation of the diabetes-specific cognitive behaviour therapy for subthreshold depression. Patients with diabetes and subthreshold depression are randomly assigned to either 2 weeks of diabetes-specific cognitive behaviour group therapy (n = 104) or to standard diabetes education programme only (n = 104). Patients are followed for 12 months. During this period data on total health sector costs, patient costs and societal productivity costs are collected in addition to clinical data. Health related quality of life (the SF-36 and the EQ-5D) is measured at baseline, immediately after the intervention, at 6 and at 12 months after the intervention. Quality adjusted life years (QALYs), and cumulative costs will be estimated for each arm of the trial. Cost-effectiveness of the diabetes-specific cognitive behaviour group therapy will be analysed from the perspective of the German statutory health insurance and from the societal perspective. To this end, incremental cost-effectiveness ratio (ICER) in terms of cost per QALY gained will be calculated.</p> <p>Discussion</p> <p>Some methodological issues of the described economic evaluation are discussed.</p> <p>Trial registration</p> <p>The trial has been registered at the Clinical Trials Register (NCT01009138).</p
Implementation of a lifestyle intervention for type 2 diabetes prevention in Dutch primary care: opportunities for intervention delivery
Resources for and barriers to effective diabetes care managementâexperiences and perspectives of people with type 2 diabetes
Exploratory analysis of the ecological variables associated with sexual health profiles in high-risk, sexually-active female learners in rural KwaZulu-Natal.
CAPRISA, 2018.Abstract available in pdf
Exploratory analysis of the ecological variables associated with sexual health profiles in high-risk, sexually-active female learners in rural KwaZulu-Natal
Young women are at high risk for negative sexual health outcomes. Despite their high risk,
many sexually-active women never experience negative sexual health outcomes. This
study explored the ecological risk factors associated with the risk profiles of sexually-active
female high school-learners in rural KwaZulu-Natal, South Africa
Nektar-Lecken beim afrikanischen Langzungen-Flughund Megaloglossus woermanni Pagenstecher, 1885
Volume: 33Start Page: 151End Page: 16
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