Astroparticle and neutrino oscillation research with KM3NeT

Two next generation underwater neutrino telescopes are under construction in the Mediterranean sea by the KM3NeT Collaboration. The first, ORCA, optimised for atmospheric neutrinos detection will be capable to determine the neutrino mass hierarchy with > 3σ after three years of operation, i.e. as early as 2023. The second, ARCA, is optimised for high energy neutrino astronomy. Its location allows for surveying most of the Galactic Plane, including the Galactic Centre and the most promising source candidates. The neutrino diffuse emission flux measured by the IceCube Collaboration can be observed with 5σ in less than one year

Endoscopic Drainage of the Pancreatic Pseudocyst through the Stomach or Duodenal Wall

In the article we have presented early outcome and long-term outcome of the usage of various methods of endoscopic drainage of the pancreatic pseudocyst through the stomach or duodenal wall in 56 patient

Endoscopic biliary stenting for post-cholecystectomy bile leaks

This paper deals analyzes the treatment experience of 15 patients with bile leakage after laparoscopic cholecystectomy. All patients have undergone endoscopic transpapillary interventions in the bile ducts, including a retrograde cholangiography, papillotomy, biliary stenting, either individually or in combination with traditional surger

The Use of Diamond - Like Carbon Coated Surgical Polypropylene Meshes for Incisional Hernia Repair

Application of diamond-like carbon (DLC) coated surgical polypropylene meshes compared to similar prostheses without coating at surgical incisional hernia repair enables to decrease intensity of local inflammatory reaction in the operation are

Diagnostics and Treatment of Acute Biliary Pancreatitis

The authors have suggested a new diagnostic algorithm to be applied in case of impacted bile duct stone of major duodenal papilla, based on prognosis of acute pancreatitis according to results of analysis of biochemical bile marker

Renal cell carcinoma drug and cell therapy: today and tomorrow

The paper also looks at clinically applicable targeted immune drugs and the principle of their effect on tumorous cells. Besides, modern clinical studies of cell drugs have been considere

Gene polimorphism and endometrium hyperplastic processes

The objective of the study was the bioinformatical study of the involvement of candidate genes in the formation of endometrium hyperplastic processe

Epistatic interactions in formation of hysteromyoma

The article highlights the bioinformatics analysis data of eight polymorphous loci among 569 patients with hysteromyoma and 981 women from the control grou

The relationship between placental gene polymorphisms and preeclampsia risk in Russian women

To study the associations of polymorphisms of the NDRG1 gene, which is differentially expressed in the placenta, with the risk of preeclampsia (PE) development. The study group included 997 women: 366 pregnant women with preeclampsia and 631 women with physiological pregnancy. Clinical and laboratory examination of pregnant women was carried out in the Perinatal Center of the Belgorod Regional Clinical Hospital of St. Joasaph. DNA was isolated from peripheral venous blood lymphocytes by phenol-chloroform extraction. All women underwent typing of four single nucleotide polymorphisms of the N-myc downstream regulated gene 1 (NDRG1). The analysis of SNPs associations with the development of preeclampsia was performed using logistic regression analysis within the framework of additive, dominant and recessive genetic model