70 research outputs found
Assessment of the risk of osteosarcoma recurrence in canine long bone replants
This paper presents data on the risk of recurrence of osteosarcoma in the tissue exposed to radiation and freezed bone replants, used for replacing of bone defects in organ-preserving surgical operations on canine long bones. The best option of reconstructive surgery during replacement of bone graft in patients with bone tumors is obtaining of graft directly during the operation from the resected bone after pretreatment. One way of anticancer treatment of replanted bone is its single-phase exposition to radiation in vitro at the dose of 200 Gray (Gy) after preliminary freezing in liquid nitrogen vapor. Despite the ongoing treatment, there is a certain risk of recurrence of osteosarcoma in tissues of the replant
Π ΡΡΠΈΠ½Π½Π°Ρ ΠΈΠ·ΠΎΠ»ΡΡΠΈΡ ΡΡΠΊΠ° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ: ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΡΠ΅Π΄Π½Π΅ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ²
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. Π‘ΡΡΠ΅ΡΡΠ²ΡΡΡ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡΡΠ²Π°, ΡΡΠΎ ΠΈΠ½ΡΡΠ»ΡΡ, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Ρ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠ΅ΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ, ΠΈΠΌΠ΅Π΅Ρ ΠΊΠ°ΡΠ΄ΠΈΠΎΡΠΌΠ±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π³Π΅Π½Π΅Π·, ΠΏΡΠΈ ΡΡΠΎΠΌ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΠΈΡΡΠΎΡΠ½ΠΈΠΊ ΡΡΠΎΠΌΠ±ΠΎΠ² β ΡΡΠΊΠΎ Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ. ΠΠ·ΠΎΠ»ΡΡΠΈΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΎΠΆΠ΅Ρ ΡΡΠ°ΡΡ Π΄ΠΎΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΈΠ»ΠΈ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²ΠΎΠΉ ΠΏΠΎΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎΠΌΡ ΠΏΡΠΈΠ΅ΠΌΡ Π°Π½ΡΠΈΠΊΠΎΠ°Π³ΡΠ»ΡΠ½ΡΠΎΠ².
Π¦Π΅Π»Ρ. ΠΡΠ΅Π½ΠΈΡΡ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠ΅ΠΉ ΡΡΡΠΈΠ½Π½ΠΎΠΉ ΠΈΠ·ΠΎΠ»ΡΡΠΈΠΈ ΡΡΠΊΠ° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ Π² ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ΅ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ° Π΄Π»Ρ ΠΊΠ°ΡΠ΄ΠΈΠΎΡ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΡΠΎΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ.
ΠΠ΅ΡΠΎΠ΄Ρ. Π ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΎΠ΄Π½ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠΈΠ»ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΡΠ°ΡΡΠ΅ 18 Π»Π΅Ρ, ΠΏΡΠΎΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ Π² ΠΠΠΠ₯ ΠΈΠΌ. Π.Π. ΠΡΡΠ°ΠΊΠ° Ρ Π΄Π΅ΠΊΠ°Π±ΡΡ 2017 Π³. ΠΏΠΎ ΡΠ½Π²Π°ΡΡ 2022 Π³. ΠΡΠΈΡΠ΅ΡΠΈΠΈ ΠΈΡΠΊΠ»ΡΡΠ΅Π½ΠΈΡ β ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΎΠ± ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΡ
ΠΈΡΡ
ΠΎΠ΄Π°Ρ
; Π³Π΅ΠΌΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ Π±ΡΠ°Ρ
ΠΈΠΎΡΠ΅ΡΠ°Π»ΡΠ½ΡΡ
ΡΠΎΡΡΠ΄ΠΎΠ²; ΡΠ°ΡΡΠΎΡΠΎΠ²Π°Ρ Π°ΠΎΡΡΠ°; ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΠΉ ΡΠ½Π΄ΠΎΠΊΠ°ΡΠ΄ΠΈΡ; Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠ΅ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΠ΅ Π²Π°ΡΠΊΡΠ»ΠΈΡΡ Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅; ΠΎΡΡΡΡΠΉ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΡΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌ, ΠΏΠΎΠ²ΡΠΎΡΠ½ΡΠ΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° Π½Π° ΠΎΡΠΊΡΡΡΠΎΠΌ ΡΠ΅ΡΠ΄ΡΠ΅, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΎΡΠ΅Π΄ΡΡΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠΈΠ½ΠΈ-Π΄ΠΎΡΡΡΠΏΠ°. Π Π°Π·Π΄Π΅Π»ΠΈΠ»ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π° 2 Π³ΡΡΠΏΠΏΡ: ΠΏΠ΅ΡΠ²Π°Ρ β Ρ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠ΅ΠΉ ΠΈΠ·ΠΎΠ»ΡΡΠΈΠ΅ΠΉ ΡΡΠΊΠ° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ, Π²ΡΠΎΡΠ°Ρ β Ρ ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΠΌ ΡΡΠΊΠΎΠΌ Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ. ΠΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ°Π·Π΄Π΅Π»ΠΈΠ»ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄ΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠ΅ΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ ΠΈ Π±Π΅Π· Π΄Π°Π½Π½ΠΎΠΉ Π°ΡΠΈΡΠΌΠΈΠΈ. ΠΠ΅ΡΠ²ΠΈΡΠ½Π°Ρ ΠΊΠΎΠ½Π΅ΡΠ½Π°Ρ ΡΠΎΡΠΊΠ° β ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈΠ½ΡΡΠ»ΡΡ. ΠΡΠΎΡΠΈΡΠ½ΡΠ΅ ΠΊΠΎΠ½Π΅ΡΠ½ΡΠ΅ ΡΠΎΡΠΊΠΈ β Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ, ΠΏΠ΅ΡΠΈΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ ΠΈΠ½ΡΠ°ΡΠΊΡ ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π° ΠΈ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΡ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ, Π²ΡΠ΅ΠΌΡ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ ΠΈ ΠΏΠ΅ΡΠ΅ΠΆΠ°ΡΠΈΡ Π°ΠΎΡΡΡ, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΡΠ΅ΡΡΠ΅ΡΠ½ΠΎΡΠΎΠΌΠΈΠΉ ΠΏΠΎ ΠΏΡΠΈΡΠΈΠ½Π΅ ΠΊΡΠΎΠ²ΠΎΡΠ΅ΡΠ΅Π½ΠΈΡ, ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠ΅Π±ΡΠ²Π°Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈ ΠΊΠ°ΡΠ΄ΠΈΠΎΡ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ΅.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² ΠΈΡΠΊΠ»ΡΡΠ΅Π½ΠΈΡ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π»ΠΈ Π³ΡΡΠΏΠΏΡ Ρ ΠΈΠ·ΠΎΠ»ΡΡΠΈΠ΅ΠΉ ΡΡΠΊΠ° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ ΠΈΠ· 216 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Ρ ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΠΌ ΡΡΠΊΠΎΠΌ Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ β ΠΈΠ· 179. Π‘ΡΠ΅Π΄ΠΈ 129 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄ΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠ΅ΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠ°Ρ ΠΈΠ·ΠΎΠ»ΡΡΠΈΡ ΡΡΠΊΠ° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ Π² 69 ΡΠ»ΡΡΠ°ΡΡ
Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° ΠΈ Π² 60 β Π½Π΅Ρ. Π‘ΡΠ΅Π΄ΠΈ 266 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π±Π΅Π· ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠΈ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅ Π΄Π°Π½Π½Π°Ρ ΠΏΡΠΎΡΠ΅Π΄ΡΡΠ° Π² 147 ΡΠ»ΡΡΠ°ΡΡ
ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΈ Π² 119 β Π½Π΅Ρ. Π‘ΠΎΠ³Π»Π°ΡΠ½ΠΎ ΠΌΠ½ΠΎΠ³ΠΎΡΠ°ΠΊΡΠΎΡΠ½ΠΎΠΌΡ ΡΠ΅Π³ΡΠ΅ΡΡΠΈΠΎΠ½Π½ΠΎΠΌΡ Π°Π½Π°Π»ΠΈΠ·Ρ ΠΠΎΠΊΡΠ° Ρ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΈΠ·ΠΎΠ»ΡΡΠΈΡ ΡΡΠΊΠ° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ β Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΡΠΉ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠ°ΡΡΠΎΡΡ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ° (ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠΊΠΎΠ² 0,20; 95% Π΄ΠΎΠ²Π΅ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π» 0,06β0,62; p = 0,006). ΠΡΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠ΅ΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ ΠΈΠ· Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΏΠΎΡΠ΅ΡΠ΅ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ² Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΡΠ΅Π΄ΡΡΡ. ΠΠΎ Π²ΡΠΎΡΠΈΡΠ½ΡΠΌ ΠΊΠΎΠ½Π΅ΡΠ½ΡΠΌ ΡΠΎΡΠΊΠ°ΠΌ ΡΠ°Π·Π»ΠΈΡΠΈΠΉ Π½Π΅ Π²ΡΡΠ²ΠΈΠ»ΠΈ.
ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ·ΠΎΠ»ΡΡΠΈΡ ΡΡΠΊΠ° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΡ β ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ° Π΄Π»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠ΅ΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ, ΠΎΠΏΠ΅ΡΠΈΡΡΠ΅ΠΌΡΡ
Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΡΠ΅Π΄ΡΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΡΡΠΈΠ½Π½ΠΎΠ³ΠΎ Π΄ΠΎΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΠΊ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌΡ ΠΊΠ°ΡΠ΄ΠΈΠΎΡ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Ρ Π½Π΅ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎ.
ΠΠΎΡΡΡΠΏΠΈΠ»Π° Π² ΡΠ΅Π΄Π°ΠΊΡΠΈΡ 12 Π΄Π΅ΠΊΠ°Π±ΡΡ 2022 Π³. ΠΡΠΏΡΠ°Π²Π»Π΅Π½Π° 4 ΡΠ΅Π½ΡΡΠ±ΡΡ 2023 Π³. ΠΡΠΈΠ½ΡΡΠ° ΠΊ ΠΏΠ΅ΡΠ°ΡΠΈ 5 ΡΠ΅Π½ΡΡΠ±ΡΡ 2023 Π³.
Π€ΠΈΠ½Π°Π½ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅ ΠΈΠΌΠ΅Π»ΠΎ ΡΠΏΠΎΠ½ΡΠΎΡΡΠΊΠΎΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠΈ.
ΠΠΎΠ½ΡΠ»ΠΈΠΊΡ ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠΎΠ²
ΠΠ²ΡΠΎΡΡ Π·Π°ΡΠ²Π»ΡΡΡ ΠΎΠ± ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ ΠΊΠΎΠ½ΡΠ»ΠΈΠΊΡΠ° ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠΎΠ²
Influence of the βActive Mixβ supplement with separate administration of antagonistic components on the structure of the mice internal organs
The question of the need for separate administration of feed additivesβ components that are antagonistic from the point of view of their chemical properties and physiological effects has long been debated among researchers. The authors have proposed a new supplement based on chelate compounds, which componentsβ effect on the organism of laboratory animals has been partially considered earlier. However, the assessment of the componentsβ effects on the morphology of the excretory and reproductive systemsβ organs has not been studied. In this regard, the work considered the effect of feed additive components with separate introduction of chemically and physiologically antagonistic components on the pathoanatomical picture, as well as the microstructure of the kidneys and testes of laboratory mice to assess potentially negative effects on the excretory and reproductive systems. The supplement was administered orally at various dosages. The organ structure was assessed after 1, 2 weeks and 1 month. The microstructure of the kidneys and testes was histologically studied in the experiment and control. The negative influence absence of the supplement components in the entire range of applied dosages is shown. The absence of visible deviations of the pathoanatomical picture during autopsy of experimental animals was noted
Assessment of the risk of osteosarcoma recurrence in canine long bone replants
This paper presents data on the risk of recurrence of osteosarcoma in the tissue exposed to radiation and freezed bone replants, used for replacing of bone defects in organ-preserving surgical operations on canine long bones. The best option of reconstructive surgery during replacement of bone graft in patients with bone tumors is obtaining of graft directly during the operation from the resected bone after pretreatment. One way of anticancer treatment of replanted bone is its single-phase exposition to radiation in vitro at the dose of 200 Gray (Gy) after preliminary freezing in liquid nitrogen vapor. Despite the ongoing treatment, there is a certain risk of recurrence of osteosarcoma in tissues of the replant
P.203 Effect of interaction between lethal yellow mutation in the agouti gene and zbtb33 gene knockout on mouse brain and behavior
Effect of inhibiting additives on the emulsion (co)polymerization of butyl acrylate and methacrylic acid
Clinical control of packed RBC transfusion in acute surgical pathology such as gastric dilation and volvulus in dogs
The main goal of the present work was the analysis of peripheral blood in case of surgical pathology in dogs with gastric dilation and volvulus as well as correction of post-operative state by RBC transfusion. Scientific supplies of domestic and foreign authors that influenced the use of blood transfusion and control of various types of correction in life-threatening conditions served as methodological basis of the scientific study. The studies used methods of clinical examination characterizing the pathogenetic aspects of the problem being studied. During the period of post-op observation of the animals anemia was detected on Day 1-7, thrombocytopenia on Day 1-3, as well as severe immunosuppression caused by the development of anesthesia and splenectomy, which was confirmed by lymphopenia and thrombocytopenia on Day 1-3. The study has shown that the use of packed red blood cells in the early post-op period reduces the severity of anemia, and the severity of the inflammatory process. Administration of donor red blood cells reduces immunosuppressive effect of splenectomy and effects of general anesthesia, triggers the production of platelets, reticulocytes, thereby stimulating cell proliferation to the reparative processes. The use of packed red blood cells in case of severe abdominal pathology in dogs in the post-op period is a promising direction for the development of hemotransfusion in the veterinary surgery
ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΡΠ°Π½ΡΡΡΠ·ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅Π»ΠΈΠ²Π°Π½ΠΈΡ ΡΡΠΈΡΡΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΡ ΠΏΡΠΈ ΠΎΡΡΡΠΎΠΉ Ρ ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΡΠ°ΠΊΠΎΠΉ ΠΊΠ°ΠΊ Π΄ΠΈΠ»Π°ΡΠ°ΡΠΈΡ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΈ Π²ΠΎΠ»ΡΠ²ΡΠ»ΡΡ Ρ ΡΠΎΠ±Π°ΠΊ.
The main goal of the present work was the analysis of peripheral blood in case of surgical pathology in dogs with gastric dilation and volvulus as well as correction of post-operative state by RBC transfusion. Scientific supplies of domestic and foreign authors that influenced the use of blood transfusion and control of various types of correction in life-threatening conditions served as methodological basis of the scientific study. The studies used methods of clinical examination characterizing the pathogenetic aspects of the problem being studied. During the period of post-op observation of the animals anemia was detected on Day 1-7, thrombocytopenia on Day 1-3, as well as severe immunosuppression caused by the development of anesthesia and splenectomy, which was confirmed by lymphopenia and thrombocytopenia on Day 1-3. The study has shown that the use of packed red blood cells in the early post-op period reduces the severity of anemia, and the severity of the inflammatory process. Administration of donor red blood cells reduces immunosuppressive effect of splenectomy and effects of general anesthesia, triggers the production of platelets, reticulocytes, thereby stimulating cell proliferation to the reparative processes. The use of packed red blood cells in case of severe abdominal pathology in dogs in the post-op period is a promising direction for the development of hemotransfusion in the veterinary surgery.ΠΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΡΠ΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ»ΡΡ Π°Π½Π°Π»ΠΈΠ· ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΠΏΡΠΈ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Ρ ΡΠΎΠ±Π°ΠΊ Ρ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΈ Π²ΠΎΠ»ΡΠ²ΡΠ»ΡΡΠΎΠΌ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΏΡΠΈ ΠΏΠ΅ΡΠ΅Π»ΠΈΠ²Π°Π½ΠΈΠΈ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ². Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΡΠ½ΠΎΠ²Ρ Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΡΠ»ΡΠΆΠΈΠ»ΠΈ Π½Π°ΡΡΠ½ΡΠ΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
Π°Π²ΡΠΎΡΠΎΠ², ΠΎΠΊΠ°Π·Π°Π²ΡΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠ΅ΡΠ΅Π»ΠΈΠ²Π°Π½ΠΈΡ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΏΡΠΈ ΡΠ³ΡΠΎΠΆΠ°ΡΡΠΈΡ
ΠΆΠΈΠ·Π½ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡΡ
. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈΡΡ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠ΅ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΠΈΠ·ΡΡΠ°Π΅ΠΌΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ. Π ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π±ΡΠ»Π° Π²ΡΡΠ²Π»Π΅Π½Π° Π°Π½Π΅ΠΌΠΈΡ Π½Π° 1-7 Π΄Π΅Π½Ρ, ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠΎΠΏΠ΅Π½ΠΈΡ Π½Π° 1-3 Π΄Π΅Π½Ρ, Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½Π°Ρ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΡ, Π²ΡΠ·Π²Π°Π½Π½Π°Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π°Π½Π΅ΡΡΠ΅Π·ΠΈΠΈ ΠΈ ΡΠΏΠ»Π΅Π½ΡΠΊΡΠΎΠΌΠΈΠΈ, ΡΡΠΎ Π±ΡΠ»ΠΎ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΎ Π»ΠΈΠΌΡΠΎΠΏΠ΅Π½ΠΈΠ΅ΠΉ ΠΈ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠΎΠΏΠ΅Π½ΠΈΠ΅ΠΉ Π½Π° Π΄Π΅Π½Ρ 1-3. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠΈΡΡΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΡ Π² ΡΠ°Π½Π½Π΅ΠΌ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΡΠ½ΠΈΠΆΠ°Π΅Ρ ΡΡΠ΅ΠΏΠ΅Π½Ρ Π°Π½Π΅ΠΌΠΈΠΈ ΠΈ ΡΡΠ΅ΠΏΠ΅Π½Ρ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π΄ΠΎΠ½ΠΎΡΡΠΊΠΈΡ
ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² ΡΠ½ΠΈΠΆΠ°Π΅Ρ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠ²Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ ΡΠΏΠ»Π΅Π½ΡΠΊΡΠΎΠΌΠΈΠΈ ΠΈ ΡΡΡΠ΅ΠΊΡΡ ΠΎΠ±ΡΠ΅ΠΉ Π°Π½Π΅ΡΡΠ΅Π·ΠΈΠΈ, Π·Π°ΠΏΡΡΠΊΠ°Π΅Ρ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²ΠΎ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠΎΠ², ΡΠ΅ΡΠΈΠΊΡΠ»ΠΎΡΠΈΡΠΎΠ², ΡΠ΅ΠΌ ΡΠ°ΠΌΡΠΌ ΡΡΠΈΠΌΡΠ»ΠΈΡΡΡ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΡΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΏΠ°ΠΊΠΎΠ²Π°Π½Π½ΡΡ
ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΈ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π±ΡΡΡΠ½ΠΎΠΉ ΠΏΠΎΠ»ΠΎΡΡΠΈ Ρ ΡΠΎΠ±Π°ΠΊ Π² ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π³Π΅ΠΌΠΎΡΡΠ°Π½ΡΡΡΠ·ΠΈΠΈ Π² Π²Π΅ΡΠ΅ΡΠΈΠ½Π°ΡΠ½ΠΎΠΉ Ρ
ΠΈΡΡΡΠ³ΠΈΠΈ
The technique for inoculation of infected and pathological material for laboratory animals
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