Danny’s Recumbent Bike Accessibility Device Final Design Report

The purpose of this document is to fully define our design solution and explain our manufacturing and testing results. Our project’s goal is to find a way to allow Danny Knutson, a retired Navy pilot and incomplete quadriplegic with limited use of his arms and an impaired sense of balance, to enter and exit his recumbent tricycle without any discomfort for him or his aide. We completed multiple interviews with Danny, patent research, existing product research, and other technical literature research in order to fully understand the problem. We synthesized this information to create a concrete list of customer wants and needs, which led to a full list of specifications that were developed using the Quality Function Deployment technique. Key specifications from this list that our design will satisfy are as follows, but not limited to: the machine’s range of motion both horizontally and vertically, level of comfortability to use, and force required by the user to operate. These specifications were accepted by our sponsor and we then began the ideation phase of the project. Once we had numerous concepts, we employed the use of a decision matrix to determine the best idea for our project. We then performed preliminary analyses, risk analysis, and cost analysis in order to further develop our concept. After completing further engineering analyses, we refined our design to meet the required specifications. We purchased all necessary components, designed the parts that must be manufactured in-house, and drew up a plan to modify ordered parts for assembly. After all parts were received and manufacturing was complete, we enacted a testing plan on the assembled device. With the device finalized, we traveled to Danny’s home in Sacramento to install the device and complete our final testing. This document details this process and the results of the projec

CLASS AND PARENTING IN ACCOUNTS OF CHILD PROTECTION: A DISCURSIVE ETHNOGRAPHY UNDER CONSTRUCTION Stef Slembrouck

for constructive comments on an earlier version of this paper. I am also grateful for the support of Chris Hall, who for more than a decade now has been a greatly-valued compagnon de route in the analysis of discursive practices of child care and protection on both sides of the Channel. Stef Slembrouck Abstract In this paper, the idea of ethnograpies of hegemony is taken up as a reflexive orientation in research which addresses the complexity of forms of domination in late modern society also by trying to come to terms with the situatednes of interactionally-established interview data. Following a number of methodological remarks on the establishment of a 'native point of view' as well as a number of observations on the data trajectories (tribulations and triangulations) which mark this particular discursive ethnography, the analysis goes on to concentrate on the ways in which case categorisation is 'spoken' through social class in one particular account of child protection. As an exercise in 'classifying the classifiers' (Bourdieu 1992: 242) 2 , the analysis highlights how professional and private talk about social problems is implicated in class-based subjectivities and involves (displaced) representations of class? However, much depends here on what we mean by 'class' when referring to a contemporary context such as the Flemish/Belgian field of child protection. If hegemony then counts as a historicising interpretative move which highlights <a> the interwovenness of domain -and profession-based discourses of social problems with discourses of class and <b> the contextualisation of particular sense-making repertoires, then it is just as much about the situational contingencies under which class and domination becomes speakable in a particular way. This, I suggest, is where ethnography becomes all-important -as an investigative strategy and as an epistemology of dialogic engagement with social theory and contemporary analyses of the late modern world

Normalizing biomedical terms by minimizing ambiguity and variability

<p>Abstract</p> <p>Background</p> <p>One of the difficulties in mapping biomedical named entities, e.g. genes, proteins, chemicals and diseases, to their concept identifiers stems from the potential variability of the terms. Soft string matching is a possible solution to the problem, but its inherent heavy computational cost discourages its use when the dictionaries are large or when real time processing is required. A less computationally demanding approach is to normalize the terms by using heuristic rules, which enables us to look up a dictionary in a constant time regardless of its size. The development of good heuristic rules, however, requires extensive knowledge of the terminology in question and thus is the bottleneck of the normalization approach.</p> <p>Results</p> <p>We present a novel framework for discovering a list of normalization rules from a dictionary in a fully automated manner. The rules are discovered in such a way that they minimize the ambiguity and variability of the terms in the dictionary. We evaluated our algorithm using two large dictionaries: a human gene/protein name dictionary built from BioThesaurus and a disease name dictionary built from UMLS.</p> <p>Conclusions</p> <p>The experimental results showed that automatically discovered rules can perform comparably to carefully crafted heuristic rules in term mapping tasks, and the computational overhead of rule application is small enough that a very fast implementation is possible. This work will help improve the performance of term-concept mapping tasks in biomedical information extraction especially when good normalization heuristics for the target terminology are not fully known.</p

Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer

High-grade serous ovarian carcinoma (HGSOC) is a cancer with dismal prognosis due to the limited effectiveness of existing chemo- and immunotherapies. To elucidate mechanisms mediating sensitivity or resistance to these therapies, we developed a fast and flexible autochthonous mouse model based on somatic introduction of HGSOC-associated genetic alterations into the ovary of immunocompetent mice using tissue electroporation. Tumors arising in these mice recapitulate the metastatic patterns and histological, molecular, and treatment response features of the human disease. By leveraging these models, we show that the ability to undergo senescence underlies the clinically observed increase in sensitivity of homologous recombination (HR)-deficient HGSOC tumors to platinum-based chemotherapy. Further, cGas/STING-mediated activation of a restricted senescence-associated secretory phenotype (SASP) was sufficient to induce immune infiltration and sensitize HR-deficient tumors to immune checkpoint blockade. In sum, our study identifies senescence propensity as a predictor of therapy response and defines a limited SASP profile that appears sufficient to confer added vulnerability to concurrent immunotherapy and, more broadly, provides a blueprint for the implementation of electroporation-based mouse models to reveal mechanisms of oncogenesis and therapy response in HGSOC

Nominalization and Alternations in Biomedical Language

Background: This paper presents data on alternations in the argument structure of common domain-specific verbs and their associated verbal nominalizations in the PennBioIE corpus. Alternation is the term in theoretical linguistics for variations in the surface syntactic form of verbs, e.g. the different forms of stimulate in FSH stimulates follicular development and follicular development is stimulated by FSH. The data is used to assess the implications of alternations for biomedical text mining systems and to test the fit of the sublanguage model to biomedical texts. Methodology/Principal Findings: We examined 1,872 tokens of the ten most common domain-specific verbs or their zerorelated nouns in the PennBioIE corpus and labelled them for the presence or absence of three alternations. We then annotated the arguments of 746 tokens of the nominalizations related to these verbs and counted alternations related to the presence or absence of arguments and to the syntactic position of non-absent arguments. We found that alternations are quite common both for verbs and for nominalizations. We also found a previously undescribed alternation involving an adjectival present participle. Conclusions/Significance: We found that even in this semantically restricted domain, alternations are quite common, and alternations involving nominalizations are exceptionally diverse. Nonetheless, the sublanguage model applies to biomedica

BMQ

BMQ: Boston Medical Quarterly was published from 1950-1966 by the Boston University School of Medicine and the Massachusetts Memorial Hospitals