The impact of physical activity, diet and stress on acne vulgaris. Pathogenesis and therapeutic procedures

Introduction Acne vulgaris is the most common skin disease that affects the majority of the population. Concepts on the pathogenesis of this disease have been changing over the years, as evidenced by the current indication of the precedence of inflammatory or immunological processes over disorders of keratinization of the outlets of hair and sebaceous units during the formation of acne lesions. Due to the complexity of the etiopathogenesis of acne vulgaris, the selection of appropriate therapeutic management is sometimes complicated. In addition, the process of treating the disease is multifaceted and time-consuming. Purpose The purpose of this review is to present the current state of knowledge on the effects of physical activity, diet and stress on acne vulgaris, as well as on the pathogenesis of acne vulgaris and the therapeutic management of patients suffering from this disease. Methods Literature was searched in PubMed and Google Scholarship databases. Publicly available books were searched. Results There is a proven precedence of inflammatory or immune processes over disorders of the keratinization of the estuaries of hair and sebaceous units during the formation of acne lesions. Conclusions Specialists should delve into the mechanism of the problem visible on the patient's skin to effectively and permanently cure the disease.    

Mental health issues during pregnancy - overview of the current knowledge

Depressive disorders of antenatal and postnatal period are diagnostic challenge, as well as increasingly frequent social problem. Incidence of antenatal depression varies from 10% to 16%. Around one third of all postpartum depression cases has its beginning during the antenatal period. From the beginning of 2019, Ministry of Health’s regulations specified for the first time the recommendation to perform screening of depressive symptoms - twice during the pregnancy and once during the perinatal period, defined as the first six weeks after the delivery. Therefore the review of current studies in the subject of mental health issues during pregnancy was conducted in order to establish possible risk factors

The Influence of social media on developing body image dissatisfaction and eating disorders

INTRODUCTION Social media platforms are commonly used worldwide, affecting every-day living of billions of people. It may impacts both self-esteem and self-evaluation of its users. Formed by social influence, the ideal beauty standards lead to an unhealthy comparison, need of external validation and pursuit of ideal appearance. Induced body image dissatisfaction could be the cause of many different eating disorders or rigorous exercises. Promoted by media, ideal body-image creates unhealthy focus on BMI, weight and shape of one’s own body. PURPOSE The aim of this study is to present the current state of knowledge on the impact of social media on evolving dissatisfaction with body image, followed by eating disorders. METHODS For the purposes of writing this article, the available literature was reviewed. The database of medical publications – PubMed database and publicly available books was searched, using keywords such as social media and body image disorders, eating disorders. RESULTS According to reviewed studies, spending more time on following social media intensifies body image disorders among both young women and men, as a result of negative upward comparison of their external appearance. A problematic social media use, passive and focused on image-related platforms, heightens a risk of developing a self-dissatisfaction and body concerns. Disordered eating behaviors are significantly connected to a frequent use of an image-related social media platforms. CONCLUSIONS Maintaining a healthy relationships with peers and parents protects self-esteem of adolescents and lowers the risk of body-image and eating disorders. A greater focus should be put on educating young people about their value, self-assessment and healthy relations

Does excessive alcohol consumption contribute to the development of anxiety disorder?

Introduction Over past decades the number of patients suffering from psychiatric disorders all around the world is constantly increasing. Thank to general awareness and less stigmatization people seek for specialist’s help more willingly. Recently, one of the most common diagnoses has been anxiety disorder and many of them also tend to abuse alcohol. So far, scientists have focused mostly on alcoholism as a consequence of anxiety disorder, due to patients’ predilection to addictions. However, ethanol can also trigger anxiety itself. Aim of the study The aim of this study is to summarize the current state of knowledge on the role of alcohol in anxiety disorder development and its pathomechanisms. Material and methods This article is based on available publications in Pubmed and Google Scholar databases. Conclusions Excessive alcohol consumption may lead to the development of anxiety disorder in some patients, as well as, many other psychiatric disturbances. However, further research must be done to find out precise pathomechanism responsible for those states

Gluten-free diet - opportunities and limitations

Objective  The aim of the study was to indicate the difficulties associated with gluten-free diet and the point of its use by people without medical indications. Another important aspect of the article was to analyze the impact of this diet on the course of chronic diseases.  Methods  For the purposes of writing this article, the available literature was reviewed. Using keywords such as gluten, gluten-free, or diet, the database of medical publications - PubMed was searched.  Results: The popularity of the gluten-free diet is growing. The reason for this is increased interest in health lifestyle and nutrition as well as the influence of the mass media. Because of that, the number of people on a gluten-free diet without medical indications is increasing. Following a gluten-free diet is associated with many difficulties. Gluten-free products are much more expensive and less available than their gluten-containing counterparts. It is associated with many obstacles in everyday life. An important aspect is also the imbalance of supplied nutrients and the risk of macro and micronutrient deficiencies, such as magnesium, zinc or selenium, as a result of the gluten-free diet. With the increasing popularity of the gluten-free diet, there are more and more studies on the potential benefits of its use in chronic diseases.  Conclusion: A gluten-free diet remains the only therapeutic option in the course of diseases such as celiac disease, non-celiac gluten sensitivity or wheat allergy. Due to the insufficient amount of data, its use is not recommended in the course of other chronic diseases and in the population of people without medical indications.&nbsp

Cystic fibrosis - Ways to improve the quality of life of patients

Introduction  Cystic fibrosis (CF) is a serious, multi-system disease. In the Caucasian population CF is the most common autosomal recessive disease, which happens for 1 person in 3,500 births [1]. In the course of CF, there is a dysfunction of many organs, mainly the respiratory and digestive systems. Symptomatic treatment of cystic fibrosis is very important. The change in daily eating habits, the use of proper breathing techniques and psychotherapy also have an impact on improving the quality of life of patients. In the past patients died at a young age. The progress in the diagnosis and treatment of cystic fibrosis has meant that nowadays more and more people are reaching adulthood. In recent years, the median survival of patients has increased to 46.2 years. [2] Purpose The aim of this review is to present the current state of knowledge about ways to improve the quality and length of life of patients with CF. Methods The literature available in the Pubmed and Google Scholarship databases was reviewed using key phrases. Results Additional methods of treatment, such as: learning the correct breathing technique, oxygen therapy, physical exercise or proper nutrition, significantly improve the living conditions of patients

Impact Of Physical Activity And Health Education On The Development Of Depression

Depression is a common mental health disorder that affects the majority of the population. The exact cause of depression is not fully understood, but various factors such as genetics, environmental stressors, and psychological factors are believed to play a role. Due to the complexity of the etiopathogenesis of depression, the selection of appropriate therapeutic management is sometimes complicated. Treatment for depression typically involves a combination of medication and psychotherapy. Antidepressant medication can help alleviate symptoms by regulating neurotransmitters in the brain, while psychotherapy can help individuals understand and change negative thoughts and behaviors. Physical activity, such as sport, has been shown to have a positive impact on mental health and can help alleviate symptoms of depression. Exercise releases endorphins, reducing stress and improving mood. Health education can also play a role in preventing and managing depression by raising awareness, reducing stigma, and teaching individuals coping skills to maintain good mental health.     &nbsp

Relation of the Types of DNA Damage to Replication Stress and the Induction of Premature Chromosome Condensation

Rozdział książki New Research Directions in DNA Repair Edited by Clark ChenThe work was funded by “POMOST” fellowship from the Foundation for Polish Science (the contract no. POMOST/2011-4/8)

Interferon alpha and rapamycin inhibit the growth of pheochromocytoma PC12 line in vitro

Wstęp: Guzy chromochłonne (pheochromocytoma/paraganglioma) należą do łagodnych lub złośliwych nowotworów neuroendokrynnych.Wobec niezadowalającej skuteczności standardowych sposobów leczenia pacjentów z rozsianą postacią choroby, wciąż poszukuje się nowych metod terapii, w tym możliwości skutecznego leczenia celowanego. W związku ze wzmożonym unaczynieniem tych nowotworów, preparaty o działaniu antyangiogennym mogą potencjalnie stanowić nową grupę leków stosowanych w leczeniu pheochromocytoma/paraganglioma.Materiał i metody: W badaniu oceniano wpływ różnych angiomodulatorów: VEGF (naczyniowo-środbłonkowy czynnik wzrostu) orazpięciu endo- i egzogennych czynników antyangiogennych (endostatyna; IFN-alfa [interferon alfa]; rapamycyna — inhibitor szlaku mTOR[mammalian target of rapamycin]; JV1-36 and SU5416 [semaxinib]) na wzrost szczurzej linii pheochromocytoma PC12.Wyniki: IFN-alfa (105 U/mL) silnie hamował wzrost komórek PC12 w hodowli 72 h, nasilając apoptozę i hamując cykl komórkowy. Rapamycynaw szerokim zakresie stężeń (10-5 to 10-8 M) nieznacznie zmniejszała żywotność komórek PC12, a w stężeniu 10-5 M także hamowałaich proliferację. VEGF, endostatyna oraz JV1-36 nie wpływały na wzrost lini PC12.Wnioski: W badaniu po raz pierwszy wykazano, że IFN-alfa hamuje wzrost linii komórkowej pheochromocytoma PC12, a także potwierdzonohamujący wpływ rapamycyny wobec tej linii komórkowej. Uzyskane wyniki sugerują zatem, że IFN-alfa oraz inhibitory szlakumTOR mogą być potencjalnie skuteczne w leczeniu złośliwych postaci guzów chromochłonnych i zachęcają do dalszych badań w tymkierunku.(Endokrynol Pol 2013; 64 (5): 368–374)Introduction: Pheochromocytomas are benign or malignant neuroendocrine tumours. The unsatisfactory efficacy of the traditionaltherapeutic methods for patients with metastatic disease results in a continuing search for more effective and targeted agents. Due to theincreased vascularisation of these tumours, inhibitors of angiogenesis could be potentially a new group of drugs in pheochromocytoma/paraganglioma therapy.Material and methods: The aim of this study was to evaluate the influence of angiomodulators: VEGF (vascular endothelial growth factor)and five endogenous and exogenous antiangiogenic compounds (endostatin; IFN-alpha [interferon alpha]; rapamycin — mTOR [mammaliantarget of rapamycin] inhibitor; JV1-36 and SU5416 (semaxinib]) on the growth of rat pheochromocytoma PC12 cell line.Results: IFN-alpha (105 U/mL) strongly inhibited PC12 growth in a 72 h culture, increasing apoptosis and arresting the cell cycle. Rapamycinin a wide range of concentrations (10-5 to 10-8 M) induced a slight inhibitory effect on PC12 viability and decreased cell proliferation at theconcentration of 10-5 M. VEGF, endostatin and JV1-36 did not influence the growth of PC12.onclusions: The study has shown for the first time that IFN-a inhibited the growth of pheochromocytoma PC12 line and confirmed theinhibitory action of rapamycin on these cells. The results suggest that IFN-alpha and mTOR inhibitors could be potentially effective in thetherapy of malignant pheochromocytoma, and encourage further study in this field.(Endokrynol Pol 2013; 64 (5): 368–374

The impact of education on the benefits of cognitive-behavioral therapy on improving the quality of life of patients after breast cancer treatment

Introduction: Treatment of breast cancer may be associated with the subsequent occurrence of many side effects, which may have a significant negative impact on the quality of life of patients after treatment. Such patients may experience bothersome menopausal symptoms, persistent pain, insomnia and depressed mood. The most common treatment to combat the above symptoms is pharmacotherapy, which in turn could also be associated with additional side effects. Cognitive-behavioral therapy can be an effective alternative to pharmacological treatment as well as an effective complementary treatment. Aim of the study: The aim of the study is to summarize the current state of knowledge on the impact of cognitive-behavioral therapy on improving quality of life of patients after breast cancer treatment. Material and methods: The literature available in the Pubmed database was reviewed using key phrases. Results: Cognitive-behavioral therapy used in patients after breast cancer treatment brings good results in combating symptoms such as anxiety, depression, menopausal symptoms, persistent, chronic pain or insomnia resulting from the above symptoms. With the above therapy, you can correct not only the severity, but above all the perception of all of the above-mentioned symptoms, which is of key importance in the context of maintaining the quality of life as before the start of treatment. Conclusion: The development of patient education on the benefits of using cognitive behavioral therapy as an adjuvant treatment after breast cancer treatment may have a beneficial effect on improving the quality of life in these patients