Late onset neutropenia during clozapine treatment

PubMedID: 11555354[No abstract available

Late-onset agranulocytosis during clozapine treatment: A case report

WOS: 000165731700467

Thyroid abnormalities in lithium-treated patients

The purposes of this study were to evaluate possible effects of lithium on thyroid function, determine the relationship among thyroid function, antibody levels, and demographic/clinical variables, and establish the prevalence of lithium-related goiter, clinical hypothyroidism, and thyroid antibodies. Forty-nine patients who had taken lithium for a minimum of 6 months were enrolled, as were 46 age- and sex-matched controls naïve to lithium use. Blood was drawn to measure levels of total and free T3, T4, thyroid-stimulating hormone (TSH), and antimicrosomal and antithyroglobulin antibodies. Thyroid volume was quantified on ultrasonography. Twenty-nine patients in the study group (59%) and 7 in the control group (15%) had goiter. Free T4 levels were significantly lower in the study group, and TSH levels were higher. Among lithium-treated patients, 12% had clinical hypothyroidism and 2% had subclinical hypothyroidism. Thyroid antibodies were present in 23% of the lithium group and 15% of the control group. No significant relationship was apparent among thyroid antibodies, thyroid volume, and clinical hypothyroidism. Our findings suggested that along with its goitrogenic effects, lithium inhibited thyroid function and led to clinical hypothyroidism. Older age, family history of thyroid disorders, and the presence of thyroid antibodies significantly influenced thyroid function in the present study

Personality disorders in patients with bipolar-I disorder

WOS: 000165731700468

Thyroid functions in lithium-treated patients

WOS: 000178905000754

Диагностика участков мостового полотна и подходов в зонах устройства деформационных швов на автодорожных мостах

The object of the study is durability of expansion joints in bridge structures; the subject of the research is the vibration response of a structure obtained under conditions of natural operation. Diagnostics of the road bridge expansion joints has been carried out in order to identify characteristic dependences  between the value of structure vibration response and types of expansion joint designs during the period of their operation while taking into account the features of the bridge structure. For this purpose, we have tested the methodology for collecting and processing data on the vibration response of the structure under natural conditions of its operation. The paper presents results of data collection on the coverage topology which have been obtained while using three-dimensional scanning method. Data collection on the vibration response of the structure has been carried out by measuring the vibration velocity and deformation of the structure. The data obtained are analyzed. As a result of testing and analysis of the obtained data, the main characteristics have been revealed: the value of base unevenness, the amplitude of vibration velocity and vibration displacement of the structure elements. Two main parameters of the dynamic impact have been assigned, adjusted for the mass of a moving vehicle, which can be used as main parameter for assessing the magnitude of the dynamic impact. A comprehensive method for assessing the dynamic impact on bridge structures has been developed and proposed in the paper, and its use will make it possible to differentiate various designs of expansion joints according to the magnitude of the dynamic impact of vehicles. This, in its turn, will contribute to formulate new recommendations on the use of specific types of expansion joints for various categories of highway, which will increase operational durability of  expansion joints and the structure as a whole.Объект исследования – долговечность деформационных швов мостовых сооружений, предмет исследования – виброотклик сооружения, полученный в условиях естественной эксплуатации. Диагностика деформационных швов автодорожных мостов проводилась с целью выявления характерных зависимостей между величиной виброотклика сооружения и типами конструкций деформационных швов в течение периода их эксплуатации с учетом особенностей мостового сооружения. Для этого апробировали методику сбора и обработки данных о виброотклике сооружения в естественных условиях его эксплуатации. В статье представлены результаты сбора данных о топологии покрытия, собранные методом трехмерного сканирования. Сбор информации о виброотклике сооружения осуществляли при помощи измерения виброскорости и деформаций сооружения. В результате испытания и анализа полученных данных выявлены основные исследуемые характеристики: величина неровности основания, амплитуда виброскорости и виброперемещение элементов сооружения. Назначены два основных параметра динамического воздействия с поправкой на массу движущегося транспортного средства, которые могут быть использованы в качестве основных для оценки величины динамического воздействия. Разработана и предложена комплексная методика оценки динамического воздействия на мостовые сооружения. Ее использование позволит дифференцировать различные конструкции деформационных швов по величине динамического воздействия транспортных средств. Это в свою очередь поможет сформулировать новые рекомендации о применении конкретных типов конструкций деформационных швов для различных категорий автомобильных дорог, что повысит долговечность эксплуатации деформационных швов и сооружения в целом