АДАПТАЦИЯ МЕТОДОВ ЦИФРОВОЙ ОБРАБОТКИ СИГНАЛОВ К ЗАДАЧЕ АНАЛИЗА РЕЧИ ПРИ НЕВРОЛОГИЧЕСКИХ ПАТОЛОГИЯХ

The methodical and software for the speech signal analysis at neurological pathologies, in particular, bulbar violations, has been offered. The approach is based on the digital signal processing methods adapted to the problem of speech analysis in clinical medicine. The result is a program developed in MatLab that performs the calculating and plotting spectrogram, histogram, kepstrogramm, frequencies of the main tone for the recorded speech tests. Approbation of the method was performed on the basis of Republican research and clinical center of neurology and neurosurgery and showed the prospects of its use for the diagnosis of bulbar syndrome.Предложено методическое и программное обеспечение для анализа речевых сигналов при неврологических патологиях, в частности, бульбарных нарушениях. В основе подхода - методы цифровой обработки сигналов, адаптированные к задаче анализа речи в клинической медицине. Результат представляет собой программу, разработанную в среде MatLab, выполняющую расчет и построение спектрограммы, гистограммы, кепстрограммы, частоты основного тона для записанных речевых тестов. Апробация разработанного авторами метода, выполненная на базе РНПЦ неврологии и нейрохирургии Министерства здравоохранения Республики Беларусь, показала перспективность его использования для диагностики бульбарного синдрома

Adaptation of digital signal processing methods to the analysis of speech in neurological pathologies

Предложено методическое и программное обеспечение для анализа речевых сигналов при неврологических патологиях, в частности, бульбарных нарушениях. В основе подхода – методы цифровой обработки сигналов, адаптированные к задаче анализа речи в клинической медицине. Результат представляет собой программу, разработанную в среде MatLab, выполняющую расчет и построение спектрограммы, гистограммы, кепстрограммы, частоты основного тона для записанных речевых тестов. Апробация разработанного авторами метода, выполненная на базе РНПЦ неврологии и нейрохирургии Министерства здравоохранения Республики Беларусь, показала перспективность его использования для диагностики бульбарного синдрома. The methodical and software for the speech signal analysis at neurological pathologies, in particular, bulbar violations, has been offered. The approach is based on the digital signal processing methods adapted to the problem of speech analysis in clinical medicine. The result is a program developed in MatLab that performs the calculating and plotting spectrogram, histogram, kepstrogramm, frequencies of the main tone for the recorded speech tests. Approbation of the method was performed on the basis of Republican research and clinical center of neurology and neurosurgery and showed the prospects of its use for the diagnosis of bulbar syndrome

The Effect of Fluorine Doping on the Characteristic Behaviour of CdTe

Fluorine which is an n-type dopant of cadmium telluride thin films was included during growth from a cadmium nitrate [Cd(NO3)2Æ4H2O] bath using an electrodeposition technique. The fluorine concentration in the Cd(NO3)2Æ4H2O baths were varied between 0.5 ppm and 50 ppm in order to determine its effect on the optical, structural, morphological and electrical properties of the as-deposited and the post-growth-treated layers. These characterisations were carried out using x-ray diffraction, ultraviolet–visible spectrophotometry, scanning electron microscopy, energy dispersive x-rays spectroscopy, photoelectrochemical cell measurement, direct current conductivity measurement and fully fabricated device characterisation. The results are systematically reported in this paper

The association of anti-CCP antibodies with disease activity in rheumatoid arthritis

Antibodies to citrullinated proteins have been described in patients with rheumatoid arthritis (RA) and these appear to be the most specific markers of the disease. Our objective was to determine the frequency of antibodies to cyclic citrullinated peptides (CCPs) in patients with RA and the association of anti-CCP antibodies with disease activity, radiological erosions and HLA DR genotype. Forty patients with RA and 38 patients with fibromyalgia were included in this study. Serum samples were collected from both patient groups with RA and fibromyalgia. Anti-CCP was measured by the corresponding enzyme-linked immunosorbent assay. Additionally, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), disease activity score (DAS), visual analog scala (VAS), HLA genotype and radiographic information were determined in patients with RA. The rate of sensitivity and specificity of anti-CCP reactivity for the diagnosis RA were measured (sensitivity 50%, specificity100%). There is no significant difference between anti-CCP (+) and anti-CCP (−) RA patients for DAS28, VAS, ESR, CRP, disease duration, HLA genotype, and radiological assessment of hand. However, there was a significant difference between anti-CCP (+) and anti-CCP (−) RA patients for RF and the radiological assessment of left and right wrists (respectively, P < 0.05, P = 0.04, P = 0.01). There was no significant correlation between anti-CCP antibody and ESR, CRP, VAS, DAS 28 or radiological assessment. A small but significant correlation was found between RF and anti-CCP antibody (P = 0.02, r = 0.35)

Методическое и аппаратно-программное обеспечение для регистрации и обработки речевых сигналов с целью диагностики неврологических заболеваний

The methodical and hardware-software on the basis of processing and analysis of speech signals for operative and objective diagnostics of neurological pathologies accompanied by speech function disorders are offered. The testing of developed methodological and software tools was carried out on the basis of the Republican Scientific and Practical Center of Neurology and Neurosurgery of the Ministry of Healthcare of Belarus and the Belarusian State University of Informatics and Radioelectronics. The results of testing revealed qualitative (based on the obtained spectrogram, kepstrogram, histogram) and quantitative (based on calculated parameters) differences between the parameters of speech signals in normal and bulbar syndrome. Preliminary results of the research confirmed the feasibility of using the methodological and hardware-software for registration and processing speech signals for diagnosis of neurological diseases.Предлагается методическое и аппаратно-программное обеспечение на основе цифровой обработки и анализа речевых сигналов для оперативной и объективной диагностики неврологических патологий, сопровождающихся нарушениями речевой функции. Апробация разработанных методических и программных средств была проведена на базе Республиканского научно-практического центра неврологии и нейрохирургии Министерства здравоохранения Республики Беларусь и Белорусского государственного университета информатики и радиоэлектроники. Результаты апробации выявили качественные (на основе полученных графиков спектрограмм, кепстрограмм, гистограмм) и количественные (на основе вычисленных параметров) различия между параметрами речевых сигналов в норме и при бульбарном синдроме. Предварительные результаты исследования подтвердили целесообразность использования разработанного авторами методического и аппаратно-программного обеспечения для регистрации и обработки речевых сигналов в диагностике неврологических заболеваний

Control of the induction of type I interferon by Peste des petits ruminants virus.

Peste des petits ruminants virus (PPRV) is a morbillivirus that produces clinical disease in goats and sheep. We have studied the induction of interferon-β (IFN-β) following infection of cultured cells with wild-type and vaccine strains of PPRV, and the effects of such infection with PPRV on the induction of IFN-β through both MDA-5 and RIG-I mediated pathways. Using both reporter assays and direct measurement of IFN-β mRNA, we have found that PPRV infection induces IFN-β only weakly and transiently, and the virus can actively block the induction of IFN-β. We have also generated mutant PPRV that lack expression of either of the viral accessory proteins (V&C) to characterize the role of these proteins in IFN-β induction during virus infection. Both PPRV_ΔV and PPRV_ΔC were defective in growth in cell culture, although in different ways. While the PPRV V protein bound to MDA-5 and, to a lesser extent, RIG-I, and over-expression of the V protein inhibited both IFN-β induction pathways, PPRV lacking V protein expression can still block IFN-β induction. In contrast, PPRV C bound to neither MDA-5 nor RIG-I, but PPRV lacking C protein expression lost the ability to block both MDA-5 and RIG-I mediated activation of IFN-β. These results shed new light on the inhibition of the induction of IFN-β by PPRV