Interrelations between changes in parameters of HRV, EEG and humoral immunity at patients with chronic pyelonephritis and cholecystitis

Kul’chyns’kyi Andriy B, Zukow Walery, Korolyshyn Tetyana A, Popovych Igor L. Interrelations between changes in parameters of HRV, EEG and humoral immunity at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2017;7(9):439-459. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1001856 http://ojs.ukw.edu.pl/index.php/johs/article/view/4933 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.09.2017. Revised 10.09.2017. Accepted: 10.09.2017. INTERRELATIONS BETWEEN CHANGES IN PARAMETERS OF HRV, EEG AND HUMORAL IMMUNITY AT PATIENTS WITH CHRONIC PYELONEPHRITIS AND CHOLECYSTITIS Andriy B Kul’chyns’kyi1,2, Walery Zukow3, Tetyana A Korolyshyn4, Igor L Popovych4 1Communal Hospital, Truskavets’, Ukraine [email protected] 2Ukrainian Scientific Research Institute of Transport Medicine, Odesa 3Nicolaus Copernicus University, Torun’, Poland [email protected] 4Department of Immunophysiology, OO Bohomolets’ Institute of Physiology, Kyiv, Ukraine [email protected] Abstract Background. The immunological homunculus conception considers somatotopic organization to СNS regulation of immune system. Previously, we have shown within the immunological homunculus conception that take place causal relationships parameters of EEG and HRV, on the one hand, and the parameters of cellular and humoral immunity as well as phagocytose, on the other hand. The purpose of this study is to find out the relationships between induced by balneotherapy changes in parameters of EEG and HRV, on the one hand, and the parameters of immunity, on the other hand. Methods. In basal conditions in 33 men and 10 women with chronic pyelonephritis and cholecystitis in remission, we recorded twice, before and after balneotherapy at the spa Truskavets’, EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). In blood estimated routine parameters of Humoral Immunity on a set of I and II levels recommended by the WHO. Results. We detected that changes in relative level CD22+ B-Lymphocytes upregulated by parasympathetic outflows and β-rhythm generating structures that are projected onto the loci O2, Fp1, F3 and F4, while downregulated by sympathetic outflows and θ-rhythm generating structures that are projected onto the locus T5. Serum level of IgA upregulated by parasympathetic outflows and α-rhythm generating structures that are projected onto the loci T3 and C3 as well as δ-rhythm generating structures onto F7 and T5, while downregulated by sympathetic outflows and θ-rhythm generating structures that are projected onto the loci T5, F7, Fp2, F3, F8 and F4. Serum level of CIC upregulated by parasympathetic outflows and α-rhythm generating structures that are projected onto the loci T4, Fp2, T3, F8 and C3 as well as θ-rhythm generating structures onto the loci T3 and T6, while downregulated by sympathetic outflows and β-rhythm generating structures that are projected onto the loci Fp1, F3 and P4 as well as δ-rhythm generating structures onto T4. Unlike the previous parameters serum level of IgM downregulated by parasympathetic outflows and α-rhythm generating structures that are projected onto the loci T3 and T6 as well as β-rhythm generating structures onto the locus T5, while upregulated by sympathetic outflows and θ-rhythm generating structures that are projected onto the loci F3, Fp2, T5, F4, O1 and F8. Serum level of IgG downregulated by parasympathetic outflows, while upregulated by sympathetic outflows and δ-rhythm generating structures that are projected onto the loci O2 and F8 as well as α-rhythm generating structures onto C3. Conclusion. The results are supplemented and refined Tracey’s immunological homunculus conception. Keywords: HRV, EEG, B-Lymphocytes, Immunoglobulines M,G,A, Circulating immune complexes, correlations

Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 3. Correlations between parameters EEG, HRV and immunogram

Kul’chyns’kyi Andriy B, Gozhenko Anatoliy I, Zukow Walery, Popovych Igor L. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 3. Correlations between parameters EEG, HRV and immunogram. Journal of Education, Health and Sport. 2017;7(3):53-71. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.265228 http://ojs.ukw.edu.pl/index.php/johs/article/view/4209 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.01.2017. Revised 21.01.2017. Accepted: 31.01.2017. NEURO-IMMUNE RELATIONSHIPS AT PATIENTS WITH CHRONIC PYELONEPHRITE AND CHOLECYSTITE. Communication 3. CORRELATIONS BETWEEN PARAMETERS EEG, HRV AND IMMUNOGRAM Andriy B Kul’chyns’kyi1, Anatoliy I Gozhenko2, Walery Zukow3, Igor L Popovych4 1Communal Hospital, Truskavets’, Ukraine [email protected] 2Ukrainian Scientific Research Institute of Transport Medicine Ministry of Health, Odesa [email protected] 3Faculty of Physical Education, Health and Tourism, Kazimierz Wielki University, Bydgoszcz, Poland [email protected] 4Department of Immunophysiology, OO Bohomolets’ Institute of Physiology, Kyiv, Ukraine [email protected] Abstracts Background. The immunological homunculus conception considers somatotopic organization to СNS regulation of immune system. We set a goal to analyze the causal relationships between parameters of EEG and HRV, on the one hand, and the parameters of immunity, on the other hand. Methods. In basal conditions in 23 men with chronic pyelonephrite and cholecystite in remission, we recorded EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). In blood estimated routine parameters of Immunity on a set of I and II levels recommended by the WHO. Results. Maximal coefficient canonical correlation (R) parameters of EEG and HRV detected with relative level CD22+ B-Lymphocytes: 0,94 (p<10-4), maximal relationships take place with Spectral Power Density (SPD) absolute (a) Fp1-α (r=-0,64) and relative (r) PSD Fp1-β (r=0,60). R with serum level IgM takes 0,90 (p<10-4), maximal relationships with rSPD O1-θ (r=0,60) and rHF HRV (r=0,52), with serum level IgG takes 0,86 (p<10-3), maximum with rSPD of β-rhythm in loci T6, O1 and O2 (r for all makes 0,40), with serum level IgA takes 0,84 (p<10-4), maximum with Asymmetry of δ-rhythm (r=0,59) and aSPD T4-θ (r=-0,50) as well as with Circulating Immune Complexes: R=0,84 (p<10-4), maximum with Bayevskiy’s Stress Index HRV (r=0,45) and rSPD T3-α (r=0,39). R with relative level CD8+ T-Lymphocytes makes 0,81 (p<10-4), maximal relationships take place with aSPD of α-rhythm in loci P4 (r=-0,38) and P3 (r=-0,31) as well as with rVLF HRV (r=-0,29). R with relative level CD4+ T-Lymphocytes makes 0,79 (p<10-3), maximum with aSPD of β-rhythm in loci F4 (r=0,40) and T3 (r=0,39). R with level CD16+ NK-Lymphocytes makes 0,71 (p=0,009), maximal relationships take place with Index of α-rhythm (r=-0,36) and Entropy SPD in locus C3. Minimal R detected with level “active” T-Lymphocytes: 0,57 (p=0,029). Conclusion. Take place neuro-immune causal relationships in bounds of immunological homunculus conception. Keywords: HRV, EEG, T-, NK-, B-Lymphocytes, Immunoglobulines M,G,A, Circulating immune complexes, correlations