Financial and credit mechanism for attraction of real investments in a system of money flows regulation

Optimization of funding sources of real investments is a key stage in development and successful functioning of enterprises' investment activity. Currently big attention is drawn to questions of state and private partnership during development of investment projects, as well as to possible prospects of development of state and private interaction forms in investment sphere, and concessions particularly. Improvement of forms of interaction between state and corporate sector of economy in the sphere of real investments and as a part of development of specific priority investment programs requiring considerable investments has a strategic federal and regional value. Thus, it is important to understand role and benefit of each participant of the investment market, to define clear statutory, legislative and contractual base, and to swiftly analyze financial efficiency of real investments at all stages of realization. In modern conditions, stable development of economy of any country depends on condition of investment process. Need to integrate finance capital and to promote investment activity is obvious in new management conditions of market relations development. The main condition of successful investment activity at each stage is a choice of effective and correct finance and credit mechanism as a tool of real investments financing. Prior to suggest modern tools of such financing, it is necessary to analyze theoretically proved program and targeted method of real investments financing within the state and private partnership, in order to improve previously examined methodology. © 2015, Mediterranean Center of Social and Educational Research. All rights reserved

Partnership of State and Business in Transcaucasia: History and Current Trends

The article aims to present generally the dynamics of political and economic systems on the territory of Transcaucasia in the period from the second millennium BC to the present. This dynamics is seen as reflecting the historical experience of the Transcaucasian societies, whih is successively preserved at the present time. Institutional aspects are studied of public-private partnership projects currently being implemented by the South-Caucasian member states of the Eastern Partnership integration association

Dual Master’s Programs as a Tool for the Formation of a Single Educational Space of the EAEU

The relevance of the topic of the article is due to the key role of higher education in the formation of the necessary compe tencies for the scientific, technological and industrial sphere of the economy of a modern state.Aim. The purpose of the article is to consider the methodological and practical issues of designing double degree master’s programs in the field of business education as one of the effective tools for the formation of a single educational space of the Eurasian Economic Union. The issues of development and implementation of joint educational programs are considered on the example of an international educational project developed at the Department of Business Informatics of the North-Western Institute of Management of the RANEPA. A substantive description of the project is given, the choice of a partner organization is substantiated, criteria for evaluating the effectiveness of the project implementation are formulated.Tasks. Give a meaningful description of the international educational project (relevance, relevance, structure, methodology and methodological novelty, competencies being formed, etc.), justify the choice of a partner organization and formulate criteria for evaluating the effectiveness of the implementation of an educational project.Methods. System approach and expert-analytical methods of research (flow methods of expertise, expert assessments).Results. The proposed methodological approach to the implementation of educational projects in the format of double diplomas allows solving the problems of internationalization of higher education, forming systems thinking, skills in working with large amounts of data and modern application packages, making non-standard decisions in the economy among students of master’s programs based on modern learning technologies. The conceptual level of the proposed approach is formed by the concepts of student-centered learning, building an individual learning trajectory for undergraduate students. The process-methodological level of the proposed approach allows the introduction of modern innovative network technologies for the implementation of the content of the disciplines of the economic mathematical cycle and the cycle of information technology, the adaptation of national educational systems to international standards and the formation of a competitive educational environment.Conclusions. The priority areas for the implementation of international educational projects are: transferring international programs to the status of network programs implemented with leading universities (including the development of double diploma programs); bringing international programs to European quality standards and requirements of international accreditation agencies; passing the international joint professional and public accreditation of international educational programs

Melatonin in Th17/Treg differentiation: the contribution of the hormone's own production by T lymphocytes

The hormone melatonin is involved in regulation of functioning of almost all organs and systems of the organism. In the immune system, T lymphocytes are an important target of melatonin: they express specific melatonin receptors with different affinities – membrane MT1 and MT2 and nuclear RORa, as well as intracellular molecules that nonspecifically bind melatonin at high concentrations. Moreover, many in vitro studies reveal their own production of melatonin by T lymphocytes in response to polyclonal activation and its involvement as autocrine or paracrine factor in the induction of IL-2 and IL-2 receptor (IL-2R) synthesis by T cells, with melatonin receptors involvement in implementation of these effects. Since IL-2/IL-2R-dependent signal is a key event in T lymphocytes proliferative response induction, intrinsic melatonin seems to be directly involved at least in the clonal expansion of these cells. In this work, we investigated the contribution of T cells’ melatonin to regulation of the next stage of T lymphocyte activation, namely, the differentiation of T helper populations Th17 and Treg. It was shown that blockade of both membrane and nuclear melatonin receptors did not cause statistically significant changes in Th17 differentiation, although the trend was fixed for a decrease. Simultaneously, CD4+FoxP3+Т cells level decreased under the nonselective blockade of membrane hormone receptors, and Treg-associated cytokine TGF-b concentration in activated cultures supernatants decreased both in case of MT1/MT2 nonselective blockade and MT2 selective blockade. The data indicate that melatonin produced by T lymphocytes in culture can contribute to the control of naive CD4+T cell differentiation into Treg in vitro, and the hormone effects are mediated by membrane melatonin receptors. The presence of a large number targets with different affinities for melatonin in T lymphocytes determines the key role of the hormone concentration in its effects on these cells. And when interpreting data on melatonin-dependent regulation of Treg, it is important to take into account the hormone’s own production by lymphocytes, since T cells’ melatonin can mask the exogenous hormone effects or interfere with its action due to competitive binding to hormone receptors

Development of Immuno-Enzymatic Monoclonal Tests-Systems for the Detection of Glanders and Melioidosis Agents

Objective of the study was the development of immune-enzymatic monoclonal test-kit for detecting glanders and melioidosis agents. Materials and methods. We used microbial cultures and hybrid cell lines obtained from the collection of the «48th Central Research Institute» of the Ministry of Defense of the Russian Federation. Hybridoma cells were incubated in the peritoneal cavity of BALB/c mice. Preparations of glanders and melioidosis monoclonal antibodies were isolated from the ascetic fluids through precipitation with ammonium sulfate and purification by means of ion-exchange chromatography. Specific components of the test-kits were subjected to freeze drying in corresponding protective media. Study of diagnostic properties of the developed test systems was performed using ELISA. Results and conclusions. We have obtained preparations of monoclonal antibodies in vivo, as well as isolated and purified immunoglobulins from ascetic fluids. We also selected the pairs of monoclonal antibodies for manufacturing specific components. Experimental series of immune-enzymatic monoclonal test-systems allowing for specific detection of glanders and melioidosis causative agents in concentrations ranging from 0.5·106 CFU/ml and higher were made. The absence of cross-reactivity with closely related saprophytes and heterologous microorganisms in concentrations of 1,0·108 CFU/ml was shown. Demonstrated was the possibility in principle to differentiate between Burkholderia malleiand Burkholderia pseudomallei using ELISA. Test systems are promising for follow up state registration as medical products for in vitro diagnostics

Manufacturing of Hybridomas-Producers of Monoclonal Anti-Bodies to Tularemia Agent Antigens

Carried out have been two experimental studies on hybridization of mouse myeloma cells and lymphocytes of BALB/c mice immunized with inactivated microbe Francisella tularensis cultures. As a result obtained have been hybridomas-producers of monoclonal antibodies (MAb) specific to the antigens of tularemia agent. Evaluated have been the prospects of its application for the detection of the agent under discussion using enzyme-linked immunoassay. Established is the fact that monoclonal antibodies produced by 31G1F10, 32E5D3, 35B11C8, 36C2F11 hybridomas make it possible to identify microbe cells of various tularemia agent strains when concentrated up to 0.5·106 mc/sm3, and do not interact with cultures of heterologous microorganisms when concentrated to 1.0·108 mc/sm3, which testifies to their specificity. These MAb are planned to be used for the construction of immune-enzyme and immune-chromatographic test-systems designed for tularemia agent detection

MICROSTRUCTURE FORMATION DURING THE CONTINUOUS COOLING OF ENGINEERING STEELS

The analysis of CCT diagrams plotted using a high-speed dilatometer is carried out. The microstructure of steels formed under continuous cooling is investigated. The influence of alloying on the hardenability of steels is determined and the dependence of the hardness of steel on the cooling rate and chemical composition is obtained.Проведен анализ термокинетических диаграмм, построенных с использованием высокоскоростного дилатометра. Исследована микроструктура сталей, формирующаяся при непрерывном охлаждении. Определено влияние легирования на устойчивость переохлажденного аустенита, а также установлена зависимость твердости стали от скорости охлаждения и химического состава

INVESTIGATION OF THE ISOTHERMAL BAINITE TRANSFORMATION IN STEEL 20CR2MN2SINIMO

A dilatometric study of the of the isothermal bainite transformation kinetics in steel 20CR2MN2SINIMO in the temperature range 300–400 °C is carried out. The experimental kinetics of bainite transformation is described by a logistic function with a high degree of adequacy. The dependence of the coefficients of the logistic function on the temperature of isothermal holding is obtained.Проведено дилатометрическое исследование кинетики изотермического бейнитного превращения в стали марки 20Х2Г2СНМА при температуре 300–400 °C. Экспериментальная кинетика бейнитного превращения с высокой степенью адекватности описана логистической функцией. Определена зависимость коэффициентов логистической функции от температуры изотермической выдержки

INFLUENCE OF WATER SATURATION ON THE STRENGTH PROPERTIES OF ROCKS

The macroscopic deformation behavior of gray granite and rhyolite was studied during bending and uniaxial compression tests in air, in water and after drying in a kiln at a temperature of 150 0C. The behavior of cracks that appeared after bending on a microscopic scale was also studied