Determining relevance of imprecise temporal intervals for cultural heritage information retrieval

Julkaisun kokoteksti on luettavissa vain Aalto-tunnuksilla.Please note that access to the fulltext is limited to Aalto staff and students.Time is an essential concept in cultural heritage applications. Instances of temporal concepts such as time intervals are used for the annotation of cultural objects and also for querying datasets containing information about these objects. Hence it is important to match query and annotation intervals by examining their similarity or closeness. One of the problems is that in many cases time intervals are imprecise. For example, the boundaries of the “Pre-Roman age” and the “Roman age” are inherently imprecise and it may be difficult to distinguish them with clear-cut intervals. In this paper we apply the fuzzy set theory to model imprecise time intervals in order to determine relevance of the relationship between two time intervals. We present a method for matching query and annotation intervals based on their weighted mutual overlapping and closeness. We present (1) methods for calculating these weights to produce a combined measure and (2) results of comparing the combined measure with human evaluators as a case study. The case study takes into consideration archaeological temporal information, which is in most cases inherently fuzzy, and therefore offers a particularly complex and challenging scenario. The results show that our new combined measure that utilizes different weighted measures together in rankings, performs the best in terms of precision and recall. It should be used when ranking annotation intervals according to a given query interval in cultural heritage information retrieval. Our approach intends to be generalizable: overlapping and closeness may be calculated between any two fuzzy temporal intervals. The presented procedure of using user evaluation results as a basis for assigning weights for overlapping and closeness could potentially be used to reveal weights in other domains and purposes as well.Non Peer reviewe

Efficacy of conventional-dose cytarabine, idarubicin and thioguanine versus intermediate-dose cytarabine and idarubicin in the induction treatment of acute myeloid leukemia : Long-term results of the prospective randomized nationwide AML-2003 study by the Finnish Leukemia Group

Objectives: AML-2003 study sought to compare the long-term efficacy and safety of IAT and IdAraC-Ida in induction chemotherapy of acute myeloid leukemia (AML) and introduce the results of an integrated genetic and clinical risk classification guided treatment strategy. Methods: Patients were randomized to receive either IAT or IdAraC-Ida as the first induction treatment. Intensified postremission strategies were employed based on measurable residual disease (MRD) and risk classification. Structured questionnaire forms were used to gather data prospectively. Results: A total of 356 AML patients with a median age of 53 years participated in the study. Long-term overall survival (OS) and relapse-free survival (RFS) were both 49% at 10 years. The median follow-up was 114 months. No significant difference in remission rate, OS or RFS was observed between the two induction treatments. Risk classification according to the protocol, MRD after the first and the last consolidation treatment affected the OS and RFS significantly (p <.001). Conclusions: Intensified cytarabine dose in the first induction treatment was not better than IAT in patients with AML. Intensification of postremission treatment in patients with clinical risk factors or MRD seems reasonable, but randomized controlled studies are warranted in the future.acceptedVersionPeer reviewe