INFORMATION OVERLOAD AT THE U.S. PATENT AND TRADEMARK OFFICE: REFRAMING THE DuTY OF DISCLOSURE IN PATENT LAW AS A SEARCH AND FILTER PROBLEM

The United States Patent and Trademark Office (USPTO) receives more prior art submissions by patent applicants than its patent examiners have the capacity to process. Although applicant prior art submissions are highly likely to contain references material to prosecution, evidence suggests that overburdened examiners often fail to utilize references submitted by applicants in their examination of patent applications. The information overload suffered by patent examiners has deleterious effects on patent quality, since examiners fail to identify and apply the references most relevant to the examination ofpatent applications. The vision of patent examiners as perfect filters of patentability and of information as always benefiting the public good is both idealistic and unrealistic. Despite their expertise, patent examiners are human and fallible, vulnerable to the effects of information processing overload and the cognitive biases attendant to decision-making by a boundedly rational actor. Failing to address these problems will likely result in frustrated applicants, overburdened patent examiners, and reduced patent quality. This Article proposes to solve both the plague of inequitable conduct allegations in litigation and the administrative burdens of complying with the duty of disclosure by reframing disclosure obligations for the information age. Reframing the duty of disclosure in this fashion would require no modifications to statutory provisions, few alterations to administrative rules and regulations, and only modest changes to existing case law. Thus, the approach suggested in this Article is both legally conservative and administratively feasible

Stormwater Management from a Beginner’s Perspective

This presentation looks at some of the day-to-day activities and work needed for operating a stormwater management program for the West Lafayette area

Learning the Ropes with Stormwater Management

This presentation will touch on topics and skills learned by a newly employed Stormwater Engineer working for the City of West Lafayette. Topics include erosion control methods and theory, the minimum controls measures (MCMs) for Indiana’s local municipalities, the Tippecanoe County Partnership for Stormwater Quality, Wabash River infrastructures, construction-site and outfall inspections, and much more

Changes in Structural Health Monitoring System Capability Due to Aircraft Environmental Factors

Structural Health Monitoring (SHM) promises to decrease the maintenance cost and increase the availability of aging aircraft fleets by fundamentally changing the way structural inspections are performed. But this promise can only be realized through the consistent and predictable performance of a SHM system throughout the entire remaining life of an aircraft. In a sensor-based SHM system, sensor signal changes are analyzed and interpreted to identify structural flaws. But aircraft environmental factors such as temperature fluctuations, cyclic strain and exposure to various aircraft fluids also have the potential to change SHM sensor signals, raising questions about long term SHM system capability. This research begins by analyzing the current USAF inspection paradigm, known aircraft environmental factors, representative structural inspection locations for the F-15 and C-130, and current SHM technologies. A design of experiments approach is used to build and execute an experiment to determine the effect of one aircraft environmental factor (cyclic strain) on a common SHM technology (PZT-based sensors). Analysis of the experimental results shows the sensors to be significantly affected by cyclic strain, and that the effects can be estimated using a power equation model. A “probability of detection (POD) degradation model” is then developed by extending existing nondestructive evaluation (NDE) POD analysis techniques. This model demonstrates how changes in sensor performance due to an aircraft environmental factor can be used to estimate the change in overall performance of the SHM system. This POD degradation model provides a common framework to predict changes in SHM system performance over the remaining life of an aircraft. An example combining the experimental results with an existing SHM POD analysis shows how the POD degradation model can be applied to current SHM research

Pediatric open long-bone fracture and subsequent deep infection risk: The importance of early hospital care

The purpose of the current study was to identify risk factors for deep infection after an open long-bone fracture in pediatric patients. Systematic billing queries were utilized to identify pediatric patients who presented to a level I trauma center from 1998 to 2019 with open long-bone fractures. There were 303 open long-bone fractures, and 24 (7.9%) of these became infected. Fractures of the tibia/fibula

Daytime sky polarization calibration limitations

The daytime sky has recently been demonstrated as a useful calibration tool for deriving polarization cross-talk properties of large astronomical telescopes. The Daniel K. Inouye Solar Telescope and other large telescopes under construction can benefit from precise polarimetric calibration of large mirrors. Several atmospheric phenomena and instrumental errors potentially limit the technique’s accuracy. At the 3.67-m AEOS telescope on Haleakala, we performed a large observing campaign with the HiVIS spectropolarimeter to identify limitations and develop algorithms for extracting consistent calibrations. Effective sampling of the telescope optical configurations and filtering of data for several derived parameters provide robustness to the derived Mueller matrix calibrations. Second-order scattering models of the sky show that this method is relatively insensitive to multiple-scattering in the sky, provided calibration observations are done in regions of high polarization degree. The technique is also insensitive to assumptions about telescope-induced polarization, provided the mirror coatings are highly reflective. Zemax-derived polarization models show agreement between the functional dependence of polarization predictions and the corresponding on-sky calibrations

RNAi reveals proteins for metabolism and protein processing associated with Langat virus infection in Ixodes scapularis (black-legged tick) ISE6 cells

Tick-borne flaviviruses (TBFs) cause thousands of human cases of encephalitis worldwide each year, with some TBF infections progressing to hemorrhagic fever. TBFs are of medical and veterinary importance and strategies to reduce flavivirus transmission by the tick vector may have significant application. Analyses of the proteome of ISE6 cells derived from the black legged tick, Ixodes scapularis infected with the TBF, Langat virus (LGTV), have provided insights into proteins and cellular processes involved with LGTV infection. Methods: RNA interference (RNAi)-induced knockdown of transcripts was used to investigate the role of ten tick proteins in the LGTV infection cycle in ISE6 cells. LGTV-infected cells were separately transfected with dsRNA corresponding to each gene of interest and the effect on LGTV genome replication and release of infectious virus was assessed by RT-qPCR and plaque assays, respectively. Results: RNAi-induced knockdown of transcripts for two enzymes that likely function in amino acid, carbohydrate, lipid, terpenoid/polykeytide and vitamin metabolism, and a transcript for one protein of unknown function were associated with decreased replication of the LGTV genome and release of infectious virus from cells. The knockdown of transcripts for five enzymes predicted to function in metabolism, a protein likely associated with folding, sorting and degradation, and a protein of unknown function was associated with a decrease only in the amount of infectious LGTV released from cells. Conclusions: These data suggest tick proteins potentially associated with metabolism and protein processing may be involved in LGTV infection of ISE6 cells. Our study provides information to begin to elucidate the function of these proteins and identify targets for the development of new interventions aimed at controlling the transmission of TBFs