Unifying metastasis--Integrating intravasation, circulation and end organ colonization

Recent technological advances that have enabled the measurement of circulating tumour cells (CTCs) in patients have spurred interest in the circulatory phase of metastasis. Techniques that do not solely rely on a blood sample allow substantial biological interrogation beyond simply counting CTCs

Analysis of wake vortex flight test data behind a T-33 aircraft

Measurements of the vortex system behind a T-33 aircraft were obtained by a Learjet equipped with a boom carrying a three-wire, hot-wire anemometry probe and other instrumentation. Analysis of the measurements using a computerized geometric method indicated the vortices had a core radius of approximately 0.11 meter with a maximum velocity of 25 meters per second. The hot-wire anemometer was found to be a practical and sensitive instrument for determining in-flight vortex velocities. No longitudinal instabilities, buoyant effects or vortex breakdowns were evident in the data which included vortex wake cross sections from 0.24 to 5.22 kilometers behind the T-33

Optimum pulse shapes for stimulated Raman adiabatic passage

Stimulated Raman adiabatic passage (STIRAP), driven with pulses of optimum shape and delay has the potential of reaching fidelities high enough to make it suitable for fault-tolerant quantum information processing. The optimum pulse shapes are obtained upon reduction of STIRAP to effective two-state systems. We use the Dykhne-Davis-Pechukas (DDP) method to minimize nonadiabatic transitions and to maximize the fidelity of STIRAP. This results in a particular relation between the pulse shapes of the two fields driving the Raman process. The DDP-optimized version of STIRAP maintains its robustness against variations in the pulse intensities and durations, the single-photon detuning and possible losses from the intermediate state.Comment: 8 pages, 6 figures. submitted to Phys. Rev.

Vacuum-Stimulated Raman Scattering based on Adiabatic Passage in a High-Finesse Optical Cavity

We report on the first observation of stimulated Raman scattering from a Lambda-type three-level atom, where the stimulation is realized by the vacuum field of a high-finesse optical cavity. The scheme produces one intracavity photon by means of an adiabatic passage technique based on a counter-intuitive interaction sequence between pump laser and cavity field. This photon leaves the cavity through the less-reflecting mirror. The emission rate shows a characteristic dependence on the cavity and pump detuning, and the observed spectra have a sub-natural linewidth. The results are in excellent agreement with numerical simulations.Comment: 4 pages, 5 figure

Perspectives for the radiative return at meson factories

The measurement of the pion form factor and, more generally, of the cross section for electron-positron annihilation into hadrons through the radiative return has become an important task for high luminosity colliders such as the Phi- or B-meson factories. This quantity is crucial for predictions of the hadronic contributions to the anomalous magnetic moment of the muon, and to the running of the electromagnetic coupling. But the radiative return opens the possibility of many other physical applications. The physics potential of this method at high luminosity meson factories is discussed, the last upgraded version of the event generator PHOKHARA is presented, and future developments are highlighted.Comment: Presented at SIGHAD03: Worskhop on Hadronic Cross Section at Low Energy, Pisa,Italy, October 8th-10th, 200

Gaia Stellar Kinematics in the Head of the Orion A Cloud: Runaway Stellar Groups and Gravitational Infall

This work extends previous kinematic studies of young stars in the Head of the Orion A cloud (OMC-1/2/3/4/5). It is based on large samples of infrared, optical, and X-ray selected pre-main sequence stars with reliable radial velocities and Gaia-derived parallaxes and proper motions. Stellar kinematic groups are identified assuming they mimic the motion of their parental gas. Several groups are found to have peculiar kinematics: the NGC 1977 cluster and two stellar groups in the Extended Orion Nebula (EON) cavity are caught in the act of departing their birthplaces. The abnormal motion of NGC 1977 may have been caused by a global hierarchical cloud collapse, feedback by massive Ori OB1ab stars, supersonic turbulence, cloud-cloud collision, and/or slingshot effect; the former two models are favored by us. EON groups might have inherited anomalous motions of their parental cloudlets due to small-scale `rocket effects' from nearby OB stars. We also identify sparse stellar groups to the east and west of Orion A that are drifting from the central region, possibly a slowly expanding halo of the Orion Nebula Cluster. We confirm previously reported findings of varying line-of-sight distances to different parts of the cloud's Head with associated differences in gas velocity. Three-dimensional movies of star kinematics show contraction of the groups of stars in OMC-1 and global contraction of OMC-123 stars. Overall, the Head of Orion A region exhibits complex motions consistent with theoretical models involving hierarchical gravitational collapse in (possibly turbulent) clouds with OB stellar feedback.Comment: Accepted for publication in MNRAS. 26 pages, 13 figures. The two 3-D stellar kinematic movies, aimed as Supplementary Materials, can be found on YouTube at: https://youtu.be/B4GHCVvCYfo (`restricted' sample) and https://youtu.be/6fUu8sP0QFI (`full' sample

Polarization-controlled single photons

Vacuum-stimulated Raman transitions are driven between two magnetic substates of a rubidium-87 atom strongly coupled to an optical cavity. A magnetic field lifts the degeneracy of these states, and the atom is alternately exposed to laser pulses of two different frequencies. This produces a stream of single photons with alternating circular polarization in a predetermined spatio-temporal mode. MHz repetition rates are possible as no recycling of the atom between photon generations is required. Photon indistinguishability is tested by time-resolved two-photon interference.Comment: 4 pages, 3 figure

Towards Semantic Integration of Heterogeneous Sensor Data with Indigenous Knowledge for Drought Forecasting

In the Internet of Things (IoT) domain, various heterogeneous ubiquitous devices would be able to connect and communicate with each other seamlessly, irrespective of the domain. Semantic representation of data through detailed standardized annotation has shown to improve the integration of the interconnected heterogeneous devices. However, the semantic representation of these heterogeneous data sources for environmental monitoring systems is not yet well supported. To achieve the maximum benefits of IoT for drought forecasting, a dedicated semantic middleware solution is required. This research proposes a middleware that semantically represents and integrates heterogeneous data sources with indigenous knowledge based on a unified ontology for an accurate IoT-based drought early warning system (DEWS).Comment: 5 pages, 3 figures, In Proceedings of the Doctoral Symposium of the 16th International Middleware Conference (Middleware Doct Symposium 2015), Ivan Beschastnikh and Wouter Joosen (Eds.). ACM, New York, NY, US

Time-Resolved Two-Photon Quantum Interference

The interference of two independent single-photon pulses impinging on a beam splitter is analysed in a generalised time-resolved manner. Different aspects of the phenomenon are elaborated using different representations of the single-photon wave packets, like the decomposition into single-frequency field modes or spatio-temporal modes matching the photonic wave packets. Both representations lead to equivalent results, and a photon-by-photon analysis reveals that the quantum-mechanical two-photon interference can be interpreted as a classical one-photon interference once a first photon is detected. A novel time-dependent quantum-beat effect is predicted if the interfering photons have different frequencies. The calculation also reveals that full two-photon fringe visibility can be achieved under almost any circumstances by applying a temporal filter to the signal.Comment: 6 pages, 4 figure

Resummation of Threshold, Low- and High-Energy Expansions for Heavy-Quark Correlators

With the help of the Mellin-Barnes transform, we show how to simultaneously resum the expansion of a heavy-quark correlator around q^2=0 (low-energy), q^2= 4 m^2 (threshold, where m is the quark mass) and q^2=-\infty (high-energy) in a systematic way. We exemplify the method for the perturbative vector correlator at O(alpha_s^2) and O(alpha_s^3). We show that the coefficients, Omega(n), of the Taylor expansion of the vacuum polarization function in terms of the conformal variable \omega admit, for large n, an expansion in powers of 1/n (up to logarithms of n) that we can calculate exactly. This large-n expansion has a sign-alternating component given by the logarithms of the OPE, and a fixed-sign component given by the logarithms of the threshold expansion in the external momentum q^2.Comment: 27 pages, 8 figures. We fix typos in Eqs. (18), (27), (55) and (56). Results unchange