5,697 research outputs found
Development of a Response Spectral Ground-Motion Prediction Equation (GMPE) for Seismic-Hazard Analysis from Empirical Fourier Spectral and Duration Models
Exploring the theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes
A family of cyclometalated Au(III) complexes featuring a tridentate C^N^C scaffold has been synthesized and characterized. Microwave assisted synthesis of the ligands has also been exploited and optimized. The biological properties of the thus formed compounds have been studied in cancer cells and demonstrate generally moderate antiproliferative effects. Initial mechanistic insights have also been gained on the gold complex [Au(C^N^C)(GluS)] (3), and support the idea that the thioredoxin system may be a target for this family of compounds together with other relevant intracellular thiol-containing molecules
A mathematical framework for critical transitions: normal forms, variance and applications
Critical transitions occur in a wide variety of applications including
mathematical biology, climate change, human physiology and economics. Therefore
it is highly desirable to find early-warning signs. We show that it is possible
to classify critical transitions by using bifurcation theory and normal forms
in the singular limit. Based on this elementary classification, we analyze
stochastic fluctuations and calculate scaling laws of the variance of
stochastic sample paths near critical transitions for fast subsystem
bifurcations up to codimension two. The theory is applied to several models:
the Stommel-Cessi box model for the thermohaline circulation from geoscience,
an epidemic-spreading model on an adaptive network, an activator-inhibitor
switch from systems biology, a predator-prey system from ecology and to the
Euler buckling problem from classical mechanics. For the Stommel-Cessi model we
compare different detrending techniques to calculate early-warning signs. In
the epidemics model we show that link densities could be better variables for
prediction than population densities. The activator-inhibitor switch
demonstrates effects in three time-scale systems and points out that excitable
cells and molecular units have information for subthreshold prediction. In the
predator-prey model explosive population growth near a codimension two
bifurcation is investigated and we show that early-warnings from normal forms
can be misleading in this context. In the biomechanical model we demonstrate
that early-warning signs for buckling depend crucially on the control strategy
near the instability which illustrates the effect of multiplicative noise.Comment: minor corrections to previous versio
The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket
P pili are hairlike polymeric structures that mediate binding of uropathogenic Escherichia coli to the surface of the kidney via the PapG adhesin at their tips. PapG is composed of two domains: a lectin domain at the tip of the pilus followed by a pilin domain that comprises the initial polymerizing subunit of the 1,000-plus-subunit heteropolymeric pilus fiber. Prior to assembly, periplasmic pilin domains bind to a chaperone, PapD. PapD mediates donor strand complementation, in which a beta strand of PapD temporarily completes the pilin domain's fold, preventing premature, nonproductive interactions with other pilin subunits and facilitating subunit folding. Chaperone-subunit complexes are delivered to the outer membrane usher where donor strand exchange (DSE) replaces PapD's donated beta strand with an amino-terminal extension on the next incoming pilin subunit. This occurs via a zip-in-zip-out mechanism that initiates at a relatively accessible hydrophobic space termed the P5 pocket on the terminally incorporated pilus subunit. Here, we solve the structure of PapD in complex with the pilin domain of isoform II of PapG (PapGIIp). Our data revealed that PapGIIp adopts an immunoglobulin fold with a missing seventh strand, complemented in parallel by the G1 PapD strand, typical of pilin subunits. Comparisons with other chaperone-pilin complexes indicated that the interactive surfaces are highly conserved. Interestingly, the PapGIIp P5 pocket was in an open conformation, which, as molecular dynamics simulations revealed, switches between an open and a closed conformation due to the flexibility of the surrounding loops. Our study reveals the structural details of the DSE mechanism
Fibrin Sealants and Axillary Lymphatic Morbidity. A Systematic Review and Meta-Analysis of 23 Clinical Randomized Trials
Background: use of fibrin sealants following pelvic, paraaortic, and inguinal lymphadenec- tomy may reduce lymphatic morbidity. The aim of this meta-analysis is to evaluate if this finding applies to the axillary lymphadenectomy. Methods: randomized trials evaluating the efficacy of fibrin sealants in reducing axillary lymphatic complications were included. Lymphocele, drainage output, surgical-site complications, and hospital stay were considered as outcomes. Results: twenty-three randomized studies, including patients undergoing axillary lymphadenectomy for breast cancer, melanoma, and Hodgkin’s disease, were included. Fibrin sealants did not affect axillary lymphocele incidence nor the surgical site complications. Drainage output, days with drainage, and hospital stay were reduced when fibrin sealants were applied (p < 0.0001, p < 0.005, p = 0.008). Conclusion: fibrin sealants after axillary dissection reduce the total axillary drainage output, the duration of drainage, and the hospital stay. No effects on the incidence of postoperative lymphocele and surgical site complications rate are found
Fabrication and heating rate study of microscopic surface electrode ion traps
We report heating rate measurements in a microfabricated gold-on-sapphire
surface electrode ion trap with trapping height of approximately 240 micron.
Using the Doppler recooling method, we characterize the trap heating rates over
an extended region of the trap. The noise spectral density of the trap falls in
the range of noise spectra reported in ion traps at room temperature. We find
that during the first months of operation the heating rates increase by
approximately one order of magnitude. The increase in heating rates is largest
in the ion loading region of the trap, providing a strong hint that surface
contamination plays a major role for excessive heating rates. We discuss data
found in the literature and possible relation of anomalous heating to sources
of noise and dissipation in other systems, namely impurity atoms adsorbed on
metal surfaces and amorphous dielectrics.Comment: 17 pages, 5 figure
Singularity in the boundary resistance between superfluid He and a solid surface
We report new measurements in four cells of the thermal boundary resistance
between copper and He below but near the superfluid-transition
temperature . For fits of to the data yielded ,
whereas a fit to theoretical values based on the renormalization-group theory
yielded . Alternatively, a good fit of the theory to the data could
be obtained if the {\it amplitude} of the prediction was reduced by a factor
close to two. The results raise the question whether the boundary conditions
used in the theory should be modified.Comment: 4 pages, 4 figures, revte
The p(d,p)d and p(d,p)pn reactions as a tool for the study of the short range internal structure of the deuteron
In recent time the deuteron structure at short distances is often treated
from the point of view nonnucleonic degrees of freedom. In this paper the
measurements of T-odd polarization observables using tensor polarized deuteron
beam and polarized proton target or proton polarimeter are proposed to search
the quark configurations inside the deuteron.Comment: 12 pages, 8 Postscript figures, submitted in Phys.Atom.Nuc
Comparisons among the five ground-motion models developed using RESORCE for the prediction of response spectral accelerations due to earthquakes in Europe and the Middle East
This article presents comparisons among the five ground-motion models described in other articles within this special issue, in terms of data selection criteria, characteristics of the models and predicted peak ground and response spectral accelerations. Comparisons are also made with predictions from the Next Generation Attenuation (NGA) models to which the models presented here have similarities (e.g. a common master database has been used) but also differences (e.g. some models in this issue are nonparametric). As a result of the differing data selection criteria and derivation techniques the predicted median ground motions show considerable differences (up to a factor of two for certain scenarios), particularly for magnitudes and distances close to or beyond the range of the available observations. The predicted influence of style-of-faulting shows much variation among models whereas site amplification factors are more similar, with peak amplification at around 1s. These differences are greater than those among predictions from the NGA models. The models for aleatory variability (sigma), however, are similar and suggest that ground-motion variability from this region is slightly higher than that predicted by the NGA models, based primarily on data from California and Taiwan
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