5,319 research outputs found
Experiments on the large-scale structure of turbulence in the near-jet region
The near region of an axisymmetric, turbulent jet was investigated. Turbulence quantities, as well as mean velocities, were measured between 3 and 23 diam away from the nozzle. The mean velocity profiles were similar over most of this distance, whereas the turbulence quantities were far from equilibrium conditions. Across the jet, the rate of large-scale turbulence varied considerably; however, a Strouhal number based on local velocity, the diameter of the jet, and the frequency of the large-scale turbulent oscillation remained relatively constant. The formation of the initial instability waves and the pairing of the vortices were examined. Turbulent fluctuations were observed only downstream of the pairing process
The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus liberating arachidonic acid, which is subsequently metabolized by the actions of 5-lipoxygenase and cyclooxygenase to form LTC(4) and PGD(2), respectively. These pathways also generate reactive oxygen species (ROS), which have been proposed to contribute to FcepsilonRI-mediated signaling in mast cells. In this study, we demonstrate that, in addition to ERK1/2-dependent pathways, ERK1/2-independent pathways also regulate FcepsilonRI-mediated eicosanoid and ROS production in mast cells. A role for the Tec kinase Btk in the ERK1/2-independent regulatory pathway was revealed by the significantly attenuated FcepsilonRI-dependent PGD(2), LTC(4), and ROS production in bone marrow-derived mast cells of Btk(-/-) mice. The FcepsilonRI-dependent activation of Btk and eicosanoid and ROS generation in bone marrow-derived mast cells and human mast cells were similarly blocked by the PI3K inhibitors, Wortmannin and LY294002, indicating that Btk-regulated eicosanoid and ROS production occurs downstream of PI3K. In contrast to ERK1/2, the PI3K/Btk pathway does not regulate cytosolic phospholipase A(2) phosphorylation but rather appears to regulate the generation of ROS, LTC(4), and PGD(2) by contributing to the necessary Ca(2+) signal for the production of these molecules. These data demonstrate that strategies to decrease mast cell production of ROS and eicosanoids would have to target both ERK1/2- and PI3K/Btk-dependent pathways
Investigation of the Effects of Profile Shape on the Aerodynamic and Structural Characteristics of Thin, Two-dimensional Airfoils at Supersonic Speeds
Estimation of breed-specific heterosis effects for birth, weaning, and yearling weight in cattle
Heterosis, assumed proportional to expected breed heterozygosity, was calculated for 6834 individuals with birth, weaning and yearling weight records from Cycle VII and advanced generations of the U.S. Meat Animal Research Center (USMARC) Germplasm Evaluation (GPE) project. Breeds represented in these data included: Angus, Hereford, Red Angus, Charolais, Gelbvieh, Simmental, Limousin and Composite MARC III. Heterosis was further estimated by proportions of British × British (B × B), British × Continental (B × C) and Continental × Continental (C × C) crosses and by breed-specific combinations. Model 1 fitted fixed covariates for heterosis within biological types while Model 2 fitted random breed-specific combinations nested within the fixed biological type covariates. Direct heritability estimates (SE) for birth, weaning ,and yearling weight for Model 1 were 0.42 (0.04), 0.22 (0.03), and 0.39 (0.05), respectively. The direct heritability estimates (SE) of birth, weaning, and yearling weight for Model 2 were the same as Model 1, except yearling weight heritability was 0.38 (0.05). The B × B, B × C, and C × C heterosis estimates for birth weight were 0.47 (0.37), 0.75 (0.32), and 0.73 (0.54) kg, respectively. The B × B, B × C, and C × C heterosis estimates for weaning weight were 6.43 (1.80), 8.65 (1.54), and 5.86 (2.57) kg, respectively. Yearling weight estimates for B × B, B × C, and C × C heterosis were 17.59(3.06), 13.88 (2.63), and 9.12 (4.34) kg, respectively. Differences did exist among estimates of breed-specific heterosis for weaning and yearling weight, although the variance component associated with breed-specific heterosis was not significant. These results illustrate that there are differences in breed-specific heterosis and exploiting these differences can lead to varying levels of heterosis among mating plans
Estimation of breed-specific heterosis effects for birth, weaning, and yearling weight in cattle
Heterosis, assumed proportional to expected breed heterozygosity, was calculated for 6834 individuals with birth, weaning and yearling weight records from Cycle VII and advanced generations of the U.S. Meat Animal Research Center (USMARC) Germplasm Evaluation (GPE) project. Breeds represented in these data included: Angus, Hereford, Red Angus, Charolais, Gelbvieh, Simmental, Limousin and Composite MARC III. Heterosis was further estimated by proportions of British × British (B × B), British × Continental (B × C) and Continental × Continental (C × C) crosses and by breed-specific combinations. Model 1 fitted fixed covariates for heterosis within biological types while Model 2 fitted random breed-specific combinations nested within the fixed biological type covariates. Direct heritability estimates (SE) for birth, weaning ,and yearling weight for Model 1 were 0.42 (0.04), 0.22 (0.03), and 0.39 (0.05), respectively. The direct heritability estimates (SE) of birth, weaning, and yearling weight for Model 2 were the same as Model 1, except yearling weight heritability was 0.38 (0.05). The B × B, B × C, and C × C heterosis estimates for birth weight were 0.47 (0.37), 0.75 (0.32), and 0.73 (0.54) kg, respectively. The B × B, B × C, and C × C heterosis estimates for weaning weight were 6.43 (1.80), 8.65 (1.54), and 5.86 (2.57) kg, respectively. Yearling weight estimates for B × B, B × C, and C × C heterosis were 17.59(3.06), 13.88 (2.63), and 9.12 (4.34) kg, respectively. Differences did exist among estimates of breed-specific heterosis for weaning and yearling weight, although the variance component associated with breed-specific heterosis was not significant. These results illustrate that there are differences in breed-specific heterosis and exploiting these differences can lead to varying levels of heterosis among mating plans
The Borexino Thermal Monitoring & Management System and simulations of the fluid-dynamics of the Borexino detector under asymmetrical, changing boundary conditions
A comprehensive monitoring system for the thermal environment inside the
Borexino neutrino detector was developed and installed in order to reduce
uncertainties in determining temperatures throughout the detector. A
complementary thermal management system limits undesirable thermal couplings
between the environment and Borexino's active sections. This strategy is
bringing improved radioactive background conditions to the region of interest
for the physics signal thanks to reduced fluid mixing induced in the liquid
scintillator. Although fluid-dynamical equilibrium has not yet been fully
reached, and thermal fine-tuning is possible, the system has proven extremely
effective at stabilizing the detector's thermal conditions while offering
precise insights into its mechanisms of internal thermal transport.
Furthermore, a Computational Fluid-Dynamics analysis has been performed, based
on the empirical measurements provided by the thermal monitoring system, and
providing information into present and future thermal trends. A two-dimensional
modeling approach was implemented in order to achieve a proper understanding of
the thermal and fluid-dynamics in Borexino. It was optimized for different
regions and periods of interest, focusing on the most critical effects that
were identified as influencing background concentrations. Literature
experimental case studies were reproduced to benchmark the method and settings,
and a Borexino-specific benchmark was implemented in order to validate the
modeling approach for thermal transport. Finally, fully-convective models were
applied to understand general and specific fluid motions impacting the
detector's Active Volume.Comment: arXiv admin note: substantial text overlap with arXiv:1705.09078,
arXiv:1705.0965
Albedo and Reflection Spectra of Extrasolar Giant Planets
We generate theoretical albedo and reflection spectra for a full range of
extrasolar giant planet (EGP) models, from Jovian to 51-Pegasi class objects.
Our albedo modeling utilizes the latest atomic and molecular cross sections, a
Mie theory treatment of extinction by condensates, a variety of particle size
distributions, and an extension of the Feautrier radiative transfer method
which allows for a general treatment of the scattering phase function. We find
that due to qualitative similarities in the compositions and spectra of objects
within each of five broad effective temperature ranges, it is natural to
establish five representative EGP albedo classes: a ``Jovian'' class (T K; Class I) with tropospheric ammonia clouds, a ``water
cloud'' class (T K; Class II) primarily affected by
condensed HO, a ``clear'' class (T K; Class III)
which lacks clouds, and two high-temperature classes: Class IV (900 K
T 1500 K) for which alkali metal absorption
predominates, and Class V (T 1500 K and/or low surface
gravity ( 10 cm s)) for which a high silicate layer
shields a significant fraction of the incident radiation from alkali metal and
molecular absorption. The resonance lines of sodium and potassium are expected
to be salient features in the reflection spectra of Class III, IV, and V
objects. We derive Bond albedos and effective temperatures for the full set of
known EGPs and explore the possible effects of non-equilibrium condensed
products of photolysis above or within principal cloud decks. As in Jupiter,
such species can lower the UV/blue albedo substantially, even if present in
relatively small mixing ratios.Comment: revised LaTeX manuscript accepted to Ap.J.; also available at
http://jupiter.as.arizona.edu/~burrows/paper
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