Pharmacological efficacy of an inhibitor of arginase-2 KUD975 with L-NAME-induced endothelial dysfunction

The study of endotelio- and cardioprotective activity of finished dosage forms - tablets, film-coated, containing 10 mg of phenolic nature KUD-975, was shown a statistically significant decrease in blood pressure and the coefficient of endothelial dysfunction on the background of simulation L-NAME-induced pathology. In the group of animals treated with KUD975 found a statistically significant increase in the concentrations of stable metabolites of nitric oxide, which in addition to the normalization of vasodilation says about endothelioprotektive action of the compounds studie

The variation of the magnetic field of the Ap star HD~50169 over its 29 year rotation period

Context. The Ap stars that rotate extremely slowly, with periods of decades to centuries, represent one of the keys to the understanding of the processes leading to the differentiation of stellar rotation. Aims. We characterise the variations of the magnetic field of the Ap star HD 50169 and derive constraints about its structure. Methods. We combine published measurements of the mean longitudinal field of HD 50169 with new determinations of this field moment from circular spectropolarimetry obtained at the 6-m telescope BTA of the Special Astrophysical Observatory of the Russian Academy of Sciences. For the mean magnetic field modulus , literature data are complemented by the analysis of ESO spectra, both newly acquired and from the archive. Radial velocities are also obtained from these spectra. Results. We present the first determination of the rotation period of HD 50169, Prot = (29.04+/-0.82) y. HD 50169 is currently the longest-period Ap star for which magnetic field measurements have been obtained over more than a full cycle. The variation curves of both and have a significant degree of anharmonicity, and there is a definite phase shift between their respective extrema. We confirm that HD 50169 is a wide spectroscopic binary, refine its orbital elements, and suggest that the secondary is probably a dwarf star of spectral type M. Conclusions. The shapes and mutual phase shifts of the derived magnetic variation curves unquestionably indicate that the magnetic field of HD 50169 is not symmetric about an axis passing through its centre. Overall, HD 50169 appears similar to the bulk of the long-period Ap stars.Comment: 10 pages, 3 figures, accepted for publication in A&

HD 178892 - a cool Ap star with extremely strong magnetic field

We report a discovery of the Zeeman resolved spectral lines, corresponding to the extremely large magnetic field modulus =17.5 kG, in the cool Ap star HD 178892. The mean longitudinal field of this star reaches 7.5 kG, and its rotational modulation implies the strength of the dipolar magnetic component Bp>=23 kG. We have revised rotation period of the star using the All Sky Automated Survey photometry and determined P=8.2478 d. Rotation phases of the magnetic and photometric maxima of the star coincide with each other. We obtained Geneva photometric observation of HD 178892 and estimated Teff=7700+/-250 K using photometry and the hydrogen Balmer lines. Preliminary abundance analysis reveals abundance pattern typical of rapidly oscillating Ap stars.Comment: Accepted by Astronomy & Astrophysics; 4 pages, 4 figure

Influence of Al on the structure and in vitro behavior of hydroxyapatite nanopowders

Nanopowders of aluminum-substituted (0-20 mol %) hydroxyapatite (HA) with the average size of 40-60 nm were synthesized by the precipitation method from nitrate solutions. A series of samples were studied by various analytical tools to elucidate the peculiarities of al introductio

Influence of ripening in mother solution on characteristics of magnesium-substituted calcium phosphate powders

Effect of ripening in the mother liquor on the degree of crystallinity and dispersity of mixed powders of calcium and magnesium phosphates is studied as a function of magnesium content with the elemental composition such that (Ca + Mg)/P = 2. Ripening is found to have a positive effect on crystallinity of the apatite phase of powders. Nanocrystals with lowered tendency to aggregation are formed during the ripening period, which affords the powders with specific surface area as high as 80 m2/g. The morphology of the constituent particles depends on the magnesium content. Crystallization processes are essentially completed by the 21st day of ripenin

Raman fingerprints of ultrasmall nanodiamonds produced from adamantane

The synthesis of ultrasmall (2-5 nm) nanodiamonds purely from adamantane at pressure of 12 GPa is reported. Their structural features have been studied by Raman spectroscopy. The unusual vibration band containing a number of pronounced maxima at about 1147, 1245, 1344, and 1456 cm-1 was detected in Raman spectra. The band is confidently identified with the bending vibrational modes of CHx groups terminating the nanodiamonds surface. Excessively intense mode at 1344 cm-1 is explained by its coupling with the 1328 cm-1 diamond phonons. The Raman band found is proposed to be used for express recognition of ultrasmall nanodiamonds produced from adamantane and other hydrocarbons with a high hydrogen content. Moreover, polarized CH bonds on a diamond surface are sensitive to environmental conditions. This opens up opportunities for using the diamond produced from adamantane as ultrasmall nanosensors in biology, chemistry, and medicineComment: 12 pages, 6 figure

HD 965: An extremely peculiar A star with an extremely long rotation period

Context. One of the keys to understanding the origin of the Ap stars and their significance in the general context of stellar astrophysics is the consideration of the most extreme properties displayed by some of them. In that context, HD 965 is particularly interesting, as it combines some of the most pronounced chemical peculiarities with one of the longest rotation periods known. Aims. We characterise the variations of the magnetic field of the Ap star HD 965 and derive constraints about its structure. Methods. We combine published measurements of the mean longitudinal field of HD 965 with new determinations of this field moment from circular spectropolarimetry obtained at the 6-m telescope BTA of the Special Astrophysical Observatory of the Russian Academy of Sciences. For the mean magnetic field modulus , literature data are complemented by the analysis of ESO archive spectra. Results. We present the first determination of the rotation period of HD 965, P = (16.5+/-0.5) y. HD 965 is only the third Ap star with a period longer than 10 years for which magnetic field measurements have been obtained over more than a full cycle. The variation curve of is well approximated by a cosine wave. does not show any significant variation. The observed behaviour of these field moments is well represented by a simple model consisting of the superposition of collinear dipole, quadrupole and octupole. The distribution of neodymium over the surface of HD 965 is highly non-uniform. The element appears concentrated around the magnetic poles, especially the negative one. Conclusions. The shape of the longitudinal magnetic variation curve of HD 965 indicates that its magnetic field is essentially symmetric about an axis passing through the centre of the star. Overall, as far as its magnetic field is concerned, HD 965 appears similar to the bulk of the long-period Ap stars.Comment: 7 pages, 4 figures, accepted for publication in Astronomy & Astrophysics. arXiv admin note: text overlap with arXiv:1902.0586

Aspects of a0-f0 mixing in the reaction pn->da0

Some aspects of a0-f0 mixing effects in the reaction ${\vec p} n\to da^0_0$ with perpendicular polarized proton beam are discussed. An angular--asymmetry parameter $A$ is defined to study those effects. It is shown that, for energies close to the production threshold, the angular--asymmetry parameter $A(\theta, \phi)$ is proportional to the a0-f0 mixing amplitude for arbitrary polar and azimuthal angles $\theta$ and $\phi$ of the outgoing $a_0$ meson. This statement is also valid for arbitrary energies, but then only at polar angles $\theta=0^0$ and $\theta=90^0$. The mass dependence of the differential cross section $d\sigma/dm_{\pi^0\eta}$ in the reaction $pn\to d\pi^0\eta$ in the presence of \mix mixing is also discussed.Comment: 17 pages, 3 Figure

Spectral and localization properties of the Dirichlet wave guide with two concentric Neumann discs

Bound states of the Hamiltonian describing a quantum particle living on three dimensional straight strip of width $d$ are investigated. We impose the Neumann boundary condition on the two concentric windows of the radii $a$ and $b$ located on the opposite walls and the Dirichlet boundary condition on the remaining part of the boundary of the strip. We prove that such a system exhibits discrete eigenvalues below the essential spectrum for any $a,b>0$. When $a$ and $b$ tend to the infinity, the asymptotic of the eigenvalue is derived. A comparative analysis with the one-window case reveals that due to the additional possibility of the regulating energy spectrum the anticrossing structure builds up as a function of the inner radius with its sharpness increasing for the larger outer radius. Mathematical and physical interpretation of the obtained results is presented; namely, it is derived that the anticrossings are accompanied by the drastic changes of the wave function localization. Parallels are drawn to the other structures exhibiting similar phenomena; in particular, it is proved that, contrary to the two-dimensional geometry, at the critical Neumann radii true bound states exist.Comment: 25 pages, 7 figure