The International Register of Potentially Toxic Chemicals (IRPTC) of UNEP

Until recently there has been no international register or international network linking national registers for the exchange of information on, and for, chemical hazard assessment and control. The International Register of Potentially Toxic Chemicals (IRPTC) was established by the United Nations Environment Programme (UNEP) in 1976 and is now in full operation. The objectives assigned to the Register concern the establishment of a global network of contributing partners through which it can develop its data-bank containing relevant information for an assessment of environmental hazards caused by chemicals, and disseminate this information to decision-making bodies, national authorities, international organizations and other institutions, and to the scientific community that is concerned with the evaluation and control of chemicals in the environment. The IRPTC operations involve preparation of data profiles for chemicals, the development of a computerized data storage and retrieval system, a query-response service, and the publication of a 4-monthly Register Index, a periodical Bulletin, and other documents. These contain information on chemicals, international and national activities related to issues of chemical safety, and also legislative and regulatory measures for protection of the health of humans and of the environment from the noxious effects of chemical

Functional nitric oxide conjugate systems state/restored heart thiols of rats in modeling isadrine-pituitrin’s myocardial infarction using metabolite-tropic cardioprotector “Angiolin”

Background: According to modern researches, endothelial dysfunction (ED) is one of the primary pathogenetic elements of cardiovascular diseases (myocardial infarction [MI], ischemic heart diseases, cerebral ischemic stroke, atherosclerosis, arterial hypertension, pulmonary hypertension, heart failure, and dilated cardiomyopathy) as well as obesity, hyperlipidemia, diabetes and hyperhomocysteinemia. The aim of this work was to study the influence of potential metabolitotropic cardioprotector “Angiolin” on the parameters of conjugate systems nitric oxide (NO)/restored thiols in heart under isadrine-pituitrin MI.Methods: This study was performed on Wistar white rats weighing 190-210 g. Biochemical, immune-enzyme analysis and histoimmunechemical study were performed.Results: In histological sections of hearts of the rats receiving Angiolin in parenteral dosing 50 mg/kg 30 mins before each pituitrin injection the density of endothelial NO-synthase (NOS)-positive cells increased by 29% and the density of inducible NOS-positive cells decreased by 23.3%. In cytosolic fraction of myocardium homogenate NOS activity increased by 27%, the concentration of NO stable metabolites increased by 70% and the content of nitrosative stress marker nitrotyrosine decreased by 42% when compared with control group. At the same time in similar samples of heart homogenate the increase of restored thiol groups’ level by 53.3%, methionine - by 35.1%, cysteine - by 170% and activity of glutathione reductase - by 186% was noted. The administration of reference drug mildronate to the animals with MI in dose 100 mg/kg did not result in significant changes of the studied parameters of thiol-disulfide system and NO system of the heart when compared with control group.Conclusions: Angiolin does not influence directly on NOS in MI, but at the same time protects NO from nitrosative stress increasing restored equivalents of thiol-disulfide system