Kawa i jej prozdrowotne właściwości

The amount of coffee which is consumed by society is mainly influenced by its unique, taste, delicate aroma with spicy or chocolate notes and its properties resulting from the content of caffeine and polyphenols. Scientific research indicates that moderate coffee consumption can be part of a healthy diet and active lifestyle, which is linked with number of desired physiological phenomena, including mental and physical fitness. Scientific articles present a wide spectrum of positive effects of valuable compounds on the human body that are contained in the drink, for instance reducedmortality due to cardiovascular diseases, type 2 diabetes and cancer, or reduced risk of Parkinson’s and Alzheimer’s disease. Its beneficial properties have also been noticed by manufacturers of cosmetic products.Na ilość spożywanej kawy przez konsumentów ma wpływ przede wszystkim jej niepowtarzalny, dość głęboki smak i delikatny aromat, w którym wyczuwalne są nuty korzenne lub czekoladowe oraz jej właściwości wynikające z zawartości kofeiny i polifenoli. Doniesienia naukowe wskazują, że umiarkowana konsumpcja kawy może być częścią zdrowej diety i aktywnego trybu życia, co wiąże się z szeregiem pożądanych zjawisk fizjologicznych w tym sprawności psychicznej i fizycznej. Artykuły naukowe przedstawiają szerokie spektrum pozytywnego wpływu cennych związków zawartych w tym napoju na organizm człowieka, m.in. zmniejszenie śmiertelnościz powodu chorób sercowo-naczyniowych, cukrzycy typu 2, jak również nowotworów czy też obniżeniu ryzyka zachorowalności na chorobę Parkinsona i Alzheimera. Jej dobroczynne właściwości wykorzystywane są również w kosmeteologii

Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro

Objective. This study examines the effects of iron ions Fe3+ on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an in vitro model of iron overload in end-stage renal disease (ESRD). Material and Methods. Respiratory burst of peritoneal phagocytes was measured by chemiluminescence method. Results. At the highest used concentration of iron ions Fe3+ (100 μM), free radicals production by peritoneal phagocytes was reduced by 90% compared to control. Conclusions. Iron overload may increase the risk of infectious complications in ESRD patients

Peritonitis-induced antitumor activity of peritoneal macrophages from uremic patients.

The macrophages belong to the effector cells of both nonspecific and specific immune response. These cells generally express little cytotoxicity unless activated. The present work was intended to determine if peritoneal macrophages collected from patients on Continuous Ambulatory Peritoneal Dialysis (CAPD) during episodes of peritonitis were active against human tumor cell lines without further in vitro stimulation. We also compared macrophage antitumor potential with effectiveness of drugs used in cancer therapy (taxol and suramin). Conditioned medium (CM) of macrophages collected during inflammation-free periods did not exhibit cytostatic and cytotoxic activity against both tumor (A549 and HTB44) and non-transformed (BEAS-2B and CRL2190) cells. Exposure of tumor cells to CM of macrophages harvested during peritonitis resulted in significant suppression of proliferation, impairment of viability and induction of apoptosis, in contrast to non-transformed cells, which remained unaffected. The efficacy of CM of inflammatory macrophages as an antitumor agent appeared to be comparable to cytostatic and cytotoxic potency of taxol and suramin or, in the case of HTB44 cells, even higher. The results obtained suggest that activated human macrophages might represent a useful tool for cancer immunotherapy

Peritonitis-induced antitumor activity of peritoneal macrophages from uremic patients

The macrophages belong to the effector cells of both nonspecific and specific immune response. These cells generally express little cytotoxicity unless activated. The present work was intended to determine if peritoneal macrophages collected from patients on Continuous Ambulatory Peritoneal Dialysis (CAPD) during episodes of peritonitis were active against human tumor cell lines without further in vitro stimulation. We also compared macrophage antitumor potential with effectiveness of drugs used in cancer therapy (taxol and suramin). Conditioned medium (CM) of macrophages collected during inflammation-free periods did not exhibit cytostatic and cytotoxic activity against both tumor (A549 and HTB44) and non-transformed (BEAS-2B and CRL2190) cells. Exposure of tumor cells to CM of macrophages harvested during peritonitis resulted in significant suppression of proliferation, impairment of viability and induction of apoptosis, in contrast to non-transformed cells, which remained unaffected. The efficacy of CM of inflammatory macrophages as an antitumor agent appeared to be comparable to cytostatic and cytotoxic potency of taxol and suramin or, in the case of HTB44 cells, even higher. The results obtained suggest that activated human macrophages might represent a useful tool for cancer immunotherapy

Optimization of 2024-T3 Aluminum Alloy Friction Stir Welding Using Random Forest, XGBoost, and MLP Machine Learning Techniques

This study optimized friction stir welding (FSW) parameters for 1.6 mm thick 2024T3 aluminum alloy sheets. A 3 × 3 factorial design was employed to explore tool rotation speeds (1100 to 1300 rpm) and welding speeds (140 to 180 mm/min). Static tensile tests revealed the joints’ maximum strength at 87% relative to the base material. Hyperparameter optimization was conducted for machine learning (ML) models, including random forest and XGBoost, and multilayer perceptron artificial neural network (MLP-ANN) models, using grid search. Welding parameter optimization and extrapolation were then carried out, with final strength predictions analyzed using response surface methodology (RSM). The ML models achieved over 98% accuracy in parameter regression, demonstrating significant effectiveness in FSW process enhancement. Experimentally validated, optimized parameters resulted in an FSW joint efficiency of 93% relative to the base material. This outcome highlights the critical role of advanced analytical techniques in improving welding quality and efficiency