1,089 research outputs found
Development and evaluation of an impedance cardiographic system to measure cardiac output and other cardiac parameters Final progress report 1 Jul. 1969 - 31 Dec. 1970
Performance of impedance cardiograph for measuring heart rate and body fluid
Development and Evaluation of an Impedance Cardiographic System to Measure Cardiac Output and Other Cardiac Parameters, 1 July 1968 - 30 June 1969
Impedance cardiographic system to measure cardiac output and cardiovascular function
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Site-Specific Glycoprofiles of HDL-Associated ApoE are Correlated with HDL Functional Capacity and Unaffected by Short-Term Diet.
Since high-density lipoprotein (HDL) glycoprofiles are associated with HDL functional capacity, we set out to determine whether diet can alter the glycoprofiles of key HDL-associated proteins, including ApoE, a potent driver of chronic disease risk. Ten healthy subjects consumed a fast food (FF) and a Mediterranean (Med) diet for 4 days in randomized order, with a 4-day wash-out between treatments. A multiple reaction monitoring method was used to characterize the site-specific glycoprofiles of HDL proteins, and HDL functional capacity was analyzed. We describe for the first time that ApoE has 7 mucin-type O-glycosylation sites, which were not affected by short-term diet. The glycoprofiles of other HDL-associated proteins were also unaffected, except that a disialylated ApoC-III glycan was enriched after Med diet, and a nonsialylated ApoC-III glycan was enriched after FF diet. Twenty-five individual glycopeptides were significantly correlated with cholesterol efflux capacity and 21 glycopeptides were correlated with immunomodulatory capacity. Results from this study indicate that the glycoprofiles of HDL-associated proteins including ApoE are correlated with HDL functional capacity but generally unaffected by diet in the short term, except ApoC-III sialylation. These results suggest that HDL protein glycoprofiles are affected by both acute and long-term factors and may be useful for biomarker discovery
The European VCD System: Facilitating Public Procurement through Criteria-to-Evidence Mapping
Epithelioid Glioblastoma Presenting as Aphasia in a Young Adult with Ovarian Cancer: A Case Report
Our patient\u27s clinical history and preoperative radiographic evaluation suggested central nervous system (CNS) metastatic disease. Ultimately, final pathology revealed epithelioid glioblastoma (eGBM), a newly classified CNS primary tumor. This reinforces the importance of direct tissue sampling and including eGBM on the differential for young patients with histories of systemic cancer presenting with new CNS lesions
The branch processes of vortex filaments and Hopf Invariant Constraint on Scroll Wave
In this paper, by making use of Duan's topological current theory, the
evolution of the vortex filaments in excitable media is discussed in detail.
The vortex filaments are found generating or annihilating at the limit points
and encountering, splitting, or merging at the bifurcation points of a complex
function . It is also shown that the Hopf invariant of knotted
scroll wave filaments is preserved in the branch processes (splitting, merging,
or encountering) during the evolution of these knotted scroll wave filaments.
Furthermore, it also revealed that the "exclusion principle" in some chemical
media is just the special case of the Hopf invariant constraint, and during the
branch processes the "exclusion principle" is also protected by topology.Comment: 9 pages, 5 figure
Evolution of the Chern-Simons Vortices
Based on the gauge potential decomposition theory and the -mapping
theory, the topological inner structure of the Chern-Simons-Higgs vortex has
been showed in detail. The evolution of CSH vortices is studied from the
topological properties of the Higgs scalar field. The vortices are found
generating or annihilating at the limit points and encountering, splitting or
merging at the bifurcation points of the scalar field Comment: 10 pages, 10 figure
Condition of career readiness in the United States
The 2022 inaugural Condition of Career Readiness in the United States report highlights findings and recommendations to help business and industry, federal and state agencies, elected officials, and national organizations reflect on what investments and resources are needed to support the future economic competitiveness of our nation. This inaugural report describes our states’ progress towards becoming a Career Ready Nation. The report was produced for the Coalition for Career Development Center (CCD Center) by the Boston University Center for Future Readiness with support from American Student Assistance (ASA) and the Collaborative on Academic, Social and Emotional Learning (CASEL).Coalition for Career Development Centerhttps://irp.cdn-website.com/81ac0dbc/files/uploaded/CCDC-Report-nopics-V2.pdfPublished versio
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Strain-induced structure and oxygen transport interactions in epitaxial La<inf>0.6</inf>Sr<inf>0.4</inf>CoO<inf>3−δ</inf> thin films
AbstractThe possibility to control oxygen transport in one of the most promising solid oxide fuel cell cathode materials, La0.6Sr0.4CoO3−δ, by controlling lattice strain raises questions regarding the contribution of atomic scale effects. Here, high-resolution transmission electron microscopy revealed the different atomic structures in La0.6Sr0.4CoO3−δ thin films grown under tensile and compressive strain conditions. The atomic structure of the tensile-strained film indicated significant local concentration of the oxygen vacancies, with the average value of the oxygen non-stoichiometry being much larger than for the compressive-strained film. In addition to the vacancy concentration differences that are measured by isotope exchange depth profiling, significant vacancy ordering was found in tensile-strained films. This understanding might be useful for tuning the atomic structure of La0.6Sr0.4CoO3−δ thin films to optimize cathode performance.</jats:p
A homologous production system for Trichoderma reesei secreted proteins in a cellulase-free background
Recent demands for the production of biofuels from lignocellulose led to an increased interest in engineered cellulases from Trichoderma reesei or other fungal sources. While the methods to generate such mutant cellulases on DNA level are straightforward, there is often a bottleneck in their production since a correct posttranslational processing of these enzymes is needed to obtain highly active enzymes. Their production and subsequent enzymatic analysis in the homologous host T. reesei is, however, often disturbed by the concomitant production of other endogenous cellulases. As a useful alternative, we tested the production of cellulases in T. reesei in a genetic background where cellulase formation has been impaired by deletion of the major cellulase transcriptional activator gene xyr1. Three cellulase genes (cel7a, cel7b, and cel12a) were expressed under the promoter regions of the two highly expressed genes tef1 (encoding translation elongation factor 1-alpha) or cdna1 (encoding the hypothetical protein Trire2:110879). When cultivated on d-glucose as carbon source, the Δxyr1 strain secreted all three cellulases into the medium. Related to the introduced gene copy number, the cdna1 promoter appeared to be superior to the tef1 promoter. No signs of proteolysis were detected, and the individual cellulases could be assayed over a background essentially free of other cellulases. Hence this system can be used as a vehicle for rapid and high-throughput testing of cellulase muteins in a homologous background
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