Allocating Interventions Based on Counterfactual Predictions: A Case Study on Homelessness Services

Modern statistical and machine learning methods are increasingly capable of modeling individual or personalized treatment effects by predicting counterfactual outcomes. These counterfactual predictions could be used to allocate different interventions across populations based on individual characteristics. In many domains, like social services, the availability of possible interventions can be severely resource limited. This thesis considers possible improvements to the allocation of such services in the context of homelessness service provision in a major metropolitan area. Using data from the homeless system, I show potential for substantial predicted benefits in terms of reducing the number of families who experience repeat episodes of homelessness by choosing optimal allocations (based on predicted outcomes) to a fixed number of beds in different types of homelessness service facilities. Such changes in the allocation mechanism would not be without tradeoffs, however; a significant fraction of households are predicted to have a higher probability of reentry in the optimal allocation than in the original one. I discuss the efficiency, equity and fairness issues that arise and consider potential implications for policy

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead