E-marketing Skill: An Essential Future Qualification to Compete in the Digital Era (The Effect of Social Media E-marketing to Consumers’ Shopping Behavior)

As the number of Internet users increases, the trend of online transactions also increases. E-marketing is one of the selling strategies using social media such as Facebook, Instagram, Twitter, WhatsApp, BBM and LinkedIn. The purpose of this study was to analyze the simultaneous and partial effect of e-marketing to the shopping behavior of respondents. Data were obtained from questionnaires given to 100 student respondents of Indonesian vocational education. The analytical method used in this research is the t-test and F-test using SPSS 17. Based on the results of the study, it is found that three factors affected the shopping behavior of these respondents through their online transactions via social media, namely, accessibility, currency and interactivity. All e-marketing variables influenced the behavior of consumers. However, there are also some e-marketing variables affecting the shopping behavior of the respondents in different factors. From the cultural factor, shopping behavior is influenced by the accessibility and currency variables, while an effected variable linked to personal factors is accessibility alone. For psychological factors, the only effecting variable is interactivity. But overall e-marketing variables affected the shopping behavior of respondents. In conclusion, e-marketing is an essential future qualification needed to be able to compete in the digital era.   Keywords: consumer behavior, e-marketing, online shop, social media, shopping, qualificatio

The Form of Conflict Toward Power Authority on Superhero Graphic Novel: Semiotic Analysis on The Watchmen Graphic Novel

This article elaborates upon the idea of the conflict with a power authority in a graphic novels, using the semiotic analysis method defined by Roland Barthes. It will highlight the denotation, connotation and myths of the visual signs and words. This is a piece of qualitative research and  uses constructivism as the paradigm. Primary data is taken from every chapter of the Watchmen graphic novel published during the course of 1986. Until now, The Watchmen was the only graphic novel that received a Hugo Award, a worldwide acknowledgement of this genre/format as a new form of art literature. Many themes and myths can be found in the graphic novel, which help to mould the underlying ideologies which form the narrative foundations of each plotline, and this article demonstrates how the genre can be read as a form of mass communication that itself promotes conflict todawds power authority.&nbsp

THE EFFECT OF SOCIAL MEDIA E-MARKETING TOWARDS CONSUMERS SHOPPING BEHAVIOR

Abstract: As the numbers of Internet users increase, the trend of online transactions also increase. E- marketing is one of a selling strategy using social media such as Facebook, Instagram, Twitter, Whatsapp, BBM and LinkedIn. The purpose of this study was to analyze the simultaneous and partial effect of E-Marketing to the shopping behavior of respondents. Data were obtained from questionnaires given to 100 student respondents of Indonesian vocational education. The analytical method used in this research is the t test and F test using SPSS 17. Based on results of the study it is found that three factors affected shopping behavior of these respondents through their online transaction via social media, namely accessibility, currency and interactivity. All e-marketing variables influenced the behavior of consumers. However, there are also some e-marketing variables affecting shopping behavior of respondents in different factors. From the cultural factor, shopping behavior is influenced by the accessibility and currency variables, while an effected variable linked to personal factors is accessibility alone. For psychological factors, the only effecting variable is interactivity. But overall e-marketing variables affected the shopping behavior of respondents.Keywords: Consumer behavior, E-marketing, Online shop, Social media, Shopping, Qualificatio

PfMFR3: A multidrug-resistant modulator in Plasmodium falciparum

In malaria, chemical genetics is a powerful method for assigning function to uncharacterized genes. MMV085203 and GNF-Pf-3600 are two structurally related napthoquinone phenotypic screening hits that kill both blood- and sexual-stag

Fostering Economic Resilience through ABCD Methods on a Community Engagement Program at Sidetapa Village, Buleleng, Bali

Sidetapa Village is located in Buleleng province, Bali, Indonesia. Economic resilience has become a priority due to the devastating impact of the recent pandemic on this village. This paper describes how Asset-Based Community Development (ABCD) methods used within a community engagement program implemented by the University of Indonesia can develop economic resilience in that village. ABCD is a method of helping communities to develop based on their strengths and potential. This method focuses on leveraging existing strengths within the community. The tools used are the 5D Cycle of Appreciative Inquiry. The result is a digital marketing workshop to support local craft businesses

Pex36, a Novel Peroxin Implicated in de novo Peroxisome Biogenesis

ABSTRACT OF THE THESISPex36, a Novel Peroxin Implicated in de novo Peroxisome BiogenesisByKrypton CarolinoMasters of Science in Biology University of California, San Diego, 2017 Professor Suresh Subramani, ChairIt was previously believed that peroxisomes could only form through the growth and division of pre-existing peroxisomes. In the past decade, there has been increasing evidence suggesting that peroxisomes can also form de novo. In Pichia pastoris, peroxisomal membrane proteins (PMPs) are sorted within the endoplasmic reticulum (ER) to two distinct pre-peroxisomal ER (pER) sites, from which bud two types of pre- peroxisomal vesicles (ppVs). These ppVs then fuse heterotypically to produce import-viicompetent peroxisomes. Currently, only Pex3 and Pex19 are implicated in ppV budding in P. pastoris, but their exact roles are not defined. In this study, we characterized a novel P. pastoris Pex36 protein, whose loss causes cells to display a dramatic growth delay in methanol medium due to slow peroxisome biogenesis. This growth defect in methanol is enhanced with the simultaneous deletion of another peroxin, Pex25, previously implicated in peroxisome division. Using an in vitro budding assay and fluorescence microscopy of P. pastoris Δpex36 Δpex25 cells, we found that PMPs are able to sort to the pER, but are unable to bud out, suggesting that Pex36 has a role that is redundant with Pex25, in de novo peroxisomal biogenesis, specifically in ppV budding.vii

OXPHOS deficiencies affect peroxisome proliferation by downregulating genes controlled by the SNF1 signaling pathway.

How environmental cues influence peroxisome proliferation, particularly through organelles, remains largely unknown. Yeast peroxisomes metabolize fatty acids (FA), and methylotrophic yeasts also metabolize methanol. NADH and acetyl-CoA, produced by these pathways enter mitochondria for ATP production and for anabolic reactions. During the metabolism of FA and/or methanol, the mitochondrial oxidative phosphorylation (OXPHOS) pathway accepts NADH for ATP production and maintains cellular redox balance. Remarkably, peroxisome proliferation in Pichia pastoris was abolished in NADH-shuttling- and OXPHOS mutants affecting complex I or III, or by the mitochondrial uncoupler, 2,4-dinitrophenol (DNP), indicating ATP depletion causes the phenotype. We show that mitochondrial OXPHOS deficiency inhibits expression of several peroxisomal proteins implicated in FA and methanol metabolism, as well as in peroxisome division and proliferation. These genes are regulated by the Snf1 complex (SNF1), a pathway generally activated by a high AMP/ATP ratio. In OXPHOS mutants, Snf1 is activated by phosphorylation, but Gal83, its interacting subunit, fails to translocate to the nucleus. Phenotypic defects in peroxisome proliferation observed in the OXPHOS mutants, and phenocopied by the Δgal83 mutant, were rescued by deletion of three transcriptional repressor genes (MIG1, MIG2, and NRG1) controlled by SNF1 signaling. Our results are interpreted in terms of a mechanism by which peroxisomal and mitochondrial proteins and/or metabolites influence redox and energy metabolism, while also influencing peroxisome biogenesis and proliferation, thereby exemplifying interorganellar communication and interplay involving peroxisomes, mitochondria, cytosol, and the nucleus. We discuss the physiological relevance of this work in the context of human OXPHOS deficiencies