Lifetime physical activity and risk of breast cancer in pre-and post-menopausal women

© 2015 Springer Science+Business Media New York To investigate the association between different types of physical activity (PA) and breast cancer. A case–control study of breast cancer was conducted in Western Australia from 2009 to 2011, in which 1205 women with breast cancer and 1789 frequency age-matched breast cancer-free control women were recruited. A self-administered questionnaire was used to collect information about lifetime and age-period recreational, household, occupational and transport physical activities. Detailed questions about demographic characteristics, and relevant reproductive, medical and lifestyle factors were also included. Logistic regression and restrictive cubic spline analyses were applied to investigate the association and dose–response relationship between PA and breast cancer risk. Subgroup analysis was performed regarding menopausal status. We found non-linear dose–response associations between PA and risk of breast cancer. Overall, 95–130 MET-hours/week of total lifetime PA was associated with the lowest breast cancer risk. The effects were stronger among post-menopausal women. We also found that the medium amounts of recreational PA (up to 21 MET-hours/week) were associated with lower breast cancer risk among post-menopausal women. Further analysis on the intensity of recreational PA demonstrated different dose–response associations between moderate- and vigorous-intensity recreational PA and breast cancer risk. We found that PA was associated with a reduced risk of breast cancer among post-menopausal women, but not in a linear fashion. Recreational PA of different intensities may have different dose–response associations with risk of breast cancer

Neurobiology of rodent self-grooming and its value for translational neuroscience

Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders-including models of autism spectrum disorder and obsessive compulsive disorder-that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.National Institutes of Health (U.S.) (Grant NS025529)National Institutes of Health (U.S.) (Grant HD028341)National Institutes of Health (U.S.) (Grant MH060379

Galaxy Zoo: Finding offset discs and bars in SDSS galaxies

We use multi-wavelength SDSS images and Galaxy Zoo morphologies to identify a sample of $\sim$$270$ late-type galaxies with an off-centre bar. We measure offsets in the range 0.2-2.5 kpc between the photometric centres of the stellar disc and stellar bar. The measured offsets correlate with global asymmetries of the galaxies, with those with largest offsets showing higher lopsidedness. These findings are in good agreement with predictions from simulations of dwarf-dwarf tidal interactions producing off-centre bars. We find that the majority of galaxies with off-centre bars are of Magellanic type, with a median mass of $10^{9.6} M_{\odot}$, and 91% of them having M_{\star}<3\times10^{10} M_{\odot}, the characteristic mass at which galaxies start having higher central concentrations attributed to the presence of bulges. We conduct a search for companions to test the hypothesis of tidal interactions, but find that a similar fraction of galaxies with offset bars have companions within 100 kpc as galaxies with centred bars. Although this may be due to the incompleteness of the SDSS spectroscopic survey at the faint end, alternative scenarios that give rise to offset bars such as interactions with dark companions or the effect of lopsided halo potentials should be considered. Future observations are needed to confirm possible low mass companion candidates and to determine the shape of the dark matter halo, in order to find the explanation for the off-centre bars in these galaxies