450 research outputs found
The Sinkhorn-Knopp algorithm : convergence and applications
As long as a square nonnegative matrix A contains sufficient nonzero elements, then the Sinkhorn-Knopp algorithm can be used to balance the matrix, that is, to find a diagonal scaling of A that is doubly stochastic. It is known that the convergence is linear, and an upper bound has been given for the rate of convergence for positive matrices. In this paper we give an explicit expression for the rate of convergence for fully indecomposable matrices. We describe how balancing algorithms can be used to give a measure of web page significance. We compare the measure with some well known alternatives, including PageRank. We show that, with an appropriate modi. cation, the Sinkhorn-Knopp algorithm is a natural candidate for computing the measure on enormous data sets
The SFXC software correlator for Very Long Baseline Interferometry: Algorithms and Implementation
In this paper a description is given of the SFXC software correlator,
developed and maintained at the Joint Institute for VLBI in Europe (JIVE). The
software is designed to run on generic Linux-based computing clusters. The
correlation algorithm is explained in detail, as are some of the novel modes
that software correlation has enabled, such as wide-field VLBI imaging through
the use of multiple phase centres and pulsar gating and binning. This is
followed by an overview of the software architecture. Finally, the performance
of the correlator as a function of number of CPU cores, telescopes and spectral
channels is shown.Comment: Accepted by Experimental Astronom
Measurement of the half-life of the T= mirror decay of Ne and its implication on physics beyond the standard model
The superallowed mixed mirror decay
of Ne to F is excellently suited for high precision studies of
the weak interaction. However, there is some disagreement on the value of the
half-life. In a new measurement we have determined this quantity to be
= s, which differs
from the previous world average by 3 standard deviations. The impact of this
measurement on limits for physics beyond the standard model such as the
presence of tensor currents is discussed.Comment: 5 pages, 3 figures, 1 tabl
On-line Excited-State Laser Spectroscopy of Trapped Short-Lived Ra Ions
As an important step towards an atomic parity violation experiment in one
single trapped Ra ion, laser spectroscopy experiments were performed with
on-line produced short-lived Ra ions. The isotope shift of
the 6\,^2D\,-\,7\,^2P and
6\,^2D\,-\,7\,^2P transitions and the hyperfine structure
constant of the 7\,^2S and 6\,^2D states in Ra
were measured. These values provide a benchmark for the required atomic theory.
A lower limit of ms for the lifetime of the metastable
6\,^2D state was measured by optical shelving.Comment: 4.2 pages, 6 figures, 2 tables
Isotope Shifts of the 6d\,^2D - 7p\,^2P Transition in Trapped Short-Lived Ra
Laser spectroscopy of short-lived radium isotopes in a linear Paul trap has
been performed. The isotope shifts of the 6d\,^2D -
7p\,^2P transition in Ra were measured, which are
sensitive to the short range part of the atomic wavefunctions. The results are
essential experimental input for improving the precision of atomic structure
calculation. This is indispensable for parity violation in Ra aiming at the
determination of the weak mixing angle.Comment: Accepted for publication in Physical Review A as a Rapid
Communicatio
Inguinal microbiome in patients undergoing an endovascular aneurysm repair:Application of next-generation sequencing of the 16S-23S rRNA regions
Background: Surgical site infection (SSI) remains a hazardous complication after vascular surgery. In this pilot study we investigated the inguinal microbiome in skin biopsies using histology and 16S-23S rDNA Next Generation Sequencing (NGS). Our hypothesis was that causative microorganisms of SSI are present in the inguinal microbiome. Methods: Data on surgical site infections and skin samples from the Percutaneous in Endovascular Repair versus Open (PiERO) trail were evaluated. Two patients with SSI were matched for age and comorbidity to eight matching patients of the PiERO trial. All patients were treated for an abdominal aortic aneurysm with endovascular repair. Nasal and perineal cultures were taken preoperatively to detect Staphylococcus aureus carriage. After disinfection with chlorhexidine, groin biopsies were taken to identify bacteria in deeper skin layers. All samples were subjected to histological analysis and culture-free 16S-23S rDNA NGS. Results: Staphylococcus aureus species were cultured in 5 out of 20 preoperative nasal and perineal swaps. Histology detected only a few bacteria, NGS of the 16S-23S rRNA regions identified DNA of bacterial species in all biopsies (20/20). Most identified genera and species proved to be known skin flora bacteria. No relation was found between SSIs and the preoperative microbiome. Conclusion: In this pilot study, an innovative analysis of the preoperative microbiome using 16S-23S rDNA NGS did not show a relation with the occurrence of a surgical site infection. No pathogenic bacterial species were present in the inguinal skin after disinfection with chiorhexidine
Magnetoresistance of a 2-dimensional electron gas in a random magnetic field
We report magnetoresistance measurements on a two-dimensional electron gas
(2DEG) made from a high mobility GaAs/AlGaAs heterostructure, where the
externally applied magnetic field was expelled from regions of the
semiconductor by means of superconducting lead grains randomly distributed on
the surface of the sample. A theoretical explanation in excellent agreement
with the experiment is given within the framework of the semiclassical
Boltzmann equation.Comment: REVTEX 3.0, 11 pages, 3 Postscript figures appended. The manuscript
can also be obtained from our World Wide Web server:
http://roemer.fys.ku.dk/randmag.ht
Stroma Transcriptomic and Proteomic Profile of Prostate Cancer Metastasis Xenograft Models Reveals Prognostic Value of Stroma Signatures.
Resistance acquisition to androgen deprivation treatment and metastasis progression are a major clinical issue associated with prostate cancer (PCa). The role of stroma during disease progression is insufficiently defined. Using transcriptomic and proteomic analyses on differentially aggressive patient-derived xenografts (PDXs), we investigated whether PCa tumors predispose their microenvironment (stroma) to a metastatic gene expression pattern. RNA sequencing was performed on the PCa PDXs BM18 (castration-sensitive) and LAPC9 (castration-resistant), representing different disease stages. Using organism-specific reference databases, the human-specific transcriptome (tumor) was identified and separated from the mouse-specific transcriptome (stroma). To identify proteomic changes in the tumor (human) versus the stroma (mouse), we performed human/mouse cell separation and subjected protein lysates to quantitative Tandem Mass Tag labeling and mass spectrometry. Tenascin C (TNC) was among the most abundant stromal genes, modulated by androgen levels in vivo and highly expressed in castration-resistant LAPC9 PDX. The tissue microarray of primary PCa samples (n = 210) showed that TNC is a negative prognostic marker of the clinical progression to recurrence or metastasis. Stroma markers of osteoblastic PCa bone metastases seven-up signature were induced in the stroma by the host organism in metastatic xenografts, indicating conserved mechanisms of tumor cells to induce a stromal premetastatic signature. A 50-gene list stroma signature was identified based on androgen-dependent responses, which shows a linear association with the Gleason score, metastasis progression and progression-free survival. Our data show that metastatic PCa PDXs, which differ in androgen sensitivity, trigger differential stroma responses, which show the metastasis risk stratification and prognostic biomarker potential
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