Resource consumption and patient employability during systemic therapy and biological therapy

An important aspect of the treatment of patients with psoriasis and psoriatic arthritis is the cost of the applied methods of therapy, the costs of the healthcare system associated with the treatment of such patients, and the effect of the disease on the ability to work. The costs of the health care system are the most important component of assessing the use of various methods of therapy and are characterized not only by the financial side, but also by the assessment of the workload of medical organizations and the health care system in general. Research results. During this program, it was found that the use of GIBP is associated with a decrease in the average duration of one hospitalization case: this indicator was 2.07 days, while in patients on other types of therapy it reached an average of 10.01 days. In patients receiving other types of therapy, the average number of hospitalizations in a round-the-clock hospital was significantly higher and amounted to 0.53 compared with the GAI — the indicator corresponded to 0.10. In addition, patients on the BAU were less likely to seek outpatient care and received fewer sick leaves, which were characterized by a shorter duration. Conclusions. The use of GIBP reduces the burden on the dermatological and rheumatological service, reduces the duration of hospitalizations, and significantly improves the socio-economic situation of patients due to a more significant preservation of their ability to work

Carst marble on Tyrnyauz deposit

The karst of marbles is considered as the least studied type of karst. Here we have pinpointed the karst area of the ore field of the Tyrnyauz deposit. Lithological and petrographic characteristics of the skarned marbles of Tyrnyauz are given, their chemical activity is determined. Tectonogenic fissure-karst drainage system of the deposit is analyzed. The main factors of karst formation have been determined and the development of the karst marbles of the Tyrnyauz ore field at various depths is predicte

The Role of Secondary Metabolites and Bark Chemistry in Shaping Diversity and Abundance of Epiphytic Lichens

Diversity of secondary lichen metabolites was studied in epiphytic lichens on six phorophytes—spruce, pine, birch, alder, aspen and poplar in the Middle Urals of Russia. Atranorin, usnic, fumarprotocetraric acid, zeorin, and gyrophoric acid were found in 31, 24, 23, 18, and 14 species, respectively, of 237 taxa collected. Seventy-seven species (i.e., 32% of total species documented) contained no secondary metabolites. Spectra of secondary metabolites of fruticose and foliose lichens varied on different phorophytes, while in crustose species the strong dependence on the tree species was not detected. This is different to the pH dependence of saxicolous lichens where crustose lichens were more susceptible to the rock chemistry. The results of Canonical Correspondence Analysis reveal the affinity of species containing depsides, depsidones or usnic acid to acidic substrata and those lacking secondary metabolites or containing terpenes and antraquinones to the pH-neutral bark. We suppose that phenolic compounds and flavonoids, as chemical constituents of bark, may interact with lichen symbioses and elements in phellem, and similarly to the lichen acids shape the affinity of species to the substrata. Copyright © 2022 Paukov, Teptina, Ermoshin, Kruglova and Shabardina.Russian Science Foundation, RSF: 22-24-00817AE was partially supported by the Russian Science Foundation, grant number 22-24-00817

Efficacy of adding systemic glucocorticosteroids to standard therapy in adolescents with severe acne: a randomized controlled trial

Introduction. Isotretinoin is the first-choice drug in the treatment of severe forms of acne vulgaris. The combination of systemic retinoids with durant corticosteroids helps to reduce the likelihood of developing “retinoic” dermatitis and exacerbation of acne in the initial stages of isotretinoin therapy.Purpose of the study. Determination of the effectiveness of the combined use of isotretinoin and a durant corticosteroid in the treatment of severe forms of acne vulgaris.Materials and methods. Twenty six patients with “severe” or “very severe” grade on the IGA scale were included in this randomised, controlled comparative study. Thirteen patients (group A) were treated with isotretinoin 0.5 mg/kg/day (cumulative dose from 120 to 150 mg/kg) for 8 months and 2 injections of betamethasone dipropionate + betamethasone sodium phosphate at dose 1 ml (2 mg + 5 mg/1 ml) at first month (1 injection per two weeks) and thirteen patients (group B) were treated with combined therapy with isotretinoin at a dose of 0.5 mg/kg/day (cumulative dose from 120 to 150 mg/kg) for 8 months and assessment was based on the IGA scale, counting the number of inflammatory and non-inflammatory elements, indicators DIA (dermatological index of acne) and DLQI and was done at baseline, 1, 4 and 8 months of treatment.Results. At month 8, compared to group B, group A showed more significant decrease in IGA score and 76% patients achieved “clear” or “almost clear skin” degree (76% vs. 30%). The reduction in the number of inflammatory and non-inflammatory elements showed a marked clinical improvement in group A (89.2% vs 22.3 % for nodules). The decrease in DIA was 88.3% in group A and 71.3% in group B. Exacerbations of acne were recorded in 0% (group A) vs 38.0% (group B) of patients. We also found a relationship between the achievement of a 2-point reduction in the degree on the IGA scale after 8 months and the presence of exacerbations while taking isotretinoin (p = 0.012). Analyzing the DLQI between the two, we were unable to identify statistically significant differences.Conclusions. Combines use of long acting steroid with isotretinoin provides synergic effect while minimizing the side effect of isotretinoin (decreases the number of exacerbations), demonstrates a visible effect to patients within a month, thereby increasing compliance, improving the quality of life and reducing the risk of scarring

Eurovision 2021 on the Websites of Russian TV Channels

Статья поступила в редакцию 31.07.2022 г.В статье исследуются публикации о международном музыкальном конкурсе «Евровидение-2021». Работа содержит комплексный анализ более ста публикаций шести российских телеканалов («Первый канал», «Россия 1», НТВ, «Муз-ТВ», «Пятница», «Ю») в 2021 г., предлагается типология публикаций о «Евровидении-2021», проводится сравнительный анализ данного контента на разных каналах. Авторы приходят к выводу, что международный конкурс более интересен федеральной «большой тройке», чем развлекательным молодежным каналам, а объем публикаций, тональность, тематический спектр зависят от «близости» канала к Евровидению.The article examines publications about the international music contest “Eurovision-2021”. The work contains a comprehensive analysis of more than a hundred publications of six Russian TV channels (Channel One, Russia 1, NTV, Muz-TV, Pyatnitsa, Yu) in 2021, an attempt is made to typify publications about Eurovision 2021, as well as a comparative analysis of this content on different channels is provided. The authors come to the conclusion that the international competition is more interesting for the federal “big three” than for youth entertainment channels, and the volume of publications, tone, and thematic range depend on the “proximity” of the channel to Eurovision

The effect of post-procedure care on the effectiveness of skin restoration and correction of side effects after aesthetic procedures

Introduction. The  duration of  the  skin  healing period and the  final result of  cosmetic procedures are influenced not only by the treatment protocol and the type of therapy chosen, but also by skin care in the early post-treatment period.Aim of study. Тo study the effectiveness and safety of the use of the topical agent “Traumeel® Cosmo gel” in patients in the early post-treatment period after cosmetic procedures, accompanied by traumatization of the skin.Materials and methods. 20 female patients aged 19 to 49 years, who sought help for the correction of age-related skin changes, acne vulgaris, scarring of the skin and received the procedure of cosmetological therapy, accompanied by damage to the skin. All patients were assigned to group 1 (20 patients). Depending on the method of cosmetological treatment, the external remedy “Traumeel® Cosmo gel” was applied from 2 to 3 times a day at the treated area for 7 ± 2 days.Results. According to the patients’ assessment of the effectiveness and comfort of the treatment, the use of the “Traumeel® Cosmo gel” in  the  early post-treatment period is an effective and safe method of  regenerative therapy of  the  skin  and has a  high therapeutic effectiveness, which was confirmed by the results of the study.Conclusions. Based on the results of the evaluation of the effectiveness by the doctor and patients, as well as the evaluation of the monitoring of the dermatological status, the quality of life index, the patient’s subjective assessment of their response to therapy, consider the therapeutic effectiveness to be high, significantly contributing to the improvement of the quality of life

A Mathematical Model for Complete Morphological Regression in Primary Operable HER2-Positive Breast Cancer

Background. Breast cancer (BC) is distinguished with its biological tumour subtypes as luminal A, B, HER2-positive and triple-negative. The current clinical guidelines of the Russian Ministry of Health prescribe neoadjuvant targeted chemotherapy as combined treatment in the HER2-positive cancer subtype. An adequate model for treatment efficacy prediction in such patients had been missing to date.Aim. Development of a mathematical model and its computer realisation for complete morphological regression estimation in patients with primary operable HER2-positive breast cancer.Materials and methods. Statistically significant predictors were estimated with the treatment outcome data on 103 HER2- positive breast cancer cases with neoadjuvant targeted chemotherapy. A binary logistic regression model was developed to account for a dichotomous variable dependency on certain predictors.Results and discussion. Multivariate analysis laid out a mathematical model and software “Complete morphological regression estimation in primary operable EGFR-expressing breast cancer under neoadjuvant chemotherapy”. Our results attest that the program correctly automates a systematic estimation of complete morphological regression achieved prior to neoadjuvant targeted chemotherapy and is clinically justified for optimising treatment regimens in primary operable HER2-positive BC.Conclusion. The mathematical model and computer program developed estimate the rate of complete morphological regression achieved prior to neoadjuvant targeted chemotherapy with a high 92 % sensitivity, 97.33 % specificity and 93.21% accuracy

First πK\pi K atom lifetime and πK\pi K scattering length measurements

The results of a search for hydrogen-like atoms consisting of $\pi^{\mp}K^{\pm}$ mesons are presented. Evidence for $\pi K$ atom production by 24 GeV/c protons from CERN PS interacting with a nickel target has been seen in terms of characteristic $\pi K$ pairs from their breakup in the same target ($178 \pm 49$) and from Coulomb final state interaction ($653 \pm 42$). Using these results the analysis yields a first value for the $\pi K$ atom lifetime of $\tau=(2.5_{-1.8}^{+3.0})$ fs and a first model-independent measurement of the S-wave isospin-odd $\pi K$ scattering length $\left|a_0^-\right|=\frac{1}{3}\left|a_{1/2}-a_{3/2}\right|= \left(0.11_{-0.04}^{+0.09} \right)M_{\pi}^{-1}$ ($a_I$ for isospin $I$).Comment: 14 pages, 8 figure