BD+30 3639: The Infrared Spectrum During Post-AGB Stellar Evolution

We present a radiative-transfer calculation which reproduces the infrared spectrum of the planetary nebula BD~+30$^{\circ}$3639. We calculate the transfer process through absorption and scattering in a spherical-symmetric multi-grain dust shell. The emission of transiently heated particles is taken into account, as well as polycyclic aromatic hydrocarbons. We obtain an acceptable fit to most of the spectrum, including the PAH infrared bands. At submillimetre wavelengths the observed emission is larger than the model predicts, indicating that large dust conglomerates (``f{}luffy grains'') may be needed as an additional constituent. The fit favours a distance of $\ge 2 \,$kpc, which implies that BD~+30$^\circ$3639 has evolved from a massive progenitor of several solar masses. A low dust-to-gas mass ratio is found in the ionised region. The calculations yield an original mass-loss rate of 2\times10^{-4} \msolar \peryr on the Asymptotic Giant Branch. Using this mass-loss rate, we calculate how the infrared spectrum has evolved during the post-AGB evolution. We show in particular the evolution of the IRAS colours during the preceding post-AGB evolution.Comment: accepted for publication in MNRAS. LaTeX, 15 pages, hardcopy and 8 figures available from [email protected] or [email protected]

Radio continuum monitoring of the extreme carbon star IRC+10216

We describe Very Large Array observations of the extreme carbon star IRC+10216 at 8.4, 14.9, and 22.5 GHz made over a two year period. We find possible variability correlated with the infrared phase and a cm- to sub-millimeter wavelength spectral index very close to 2. The variability, observed flux densities, and upper limit on the size are consistent with the emission arising from the stellar photosphere or a slightly larger radio photosphere.Comment: 9 pages, incl. 4 figures. To appear in Astronomy & Astrophysic

Molecular Gas in Candidate Double-Barred Galaxies II. Cooler, Less Dense Gas Associated with Stronger Central Concentrations

We have performed a multi-transition CO study of the centers of seven double-barred galaxies that exhibit a variety of molecular gas morphologies to determine if the molecular gas properties are correlated with the nuclear morphology and star forming activity. Near infrared galaxy surveys have revealed the existence of nuclear stellar bars in a large number of barred or lenticular galaxies. High resolution CO maps of these galaxies exhibit a wide range of morphologies. Recent simulations of double-barred galaxies suggest that variations in the gas properties may allow it to respond differently to similar gravitational potentials. We find that the 12CO J=3-2/J=2-1 line ratio is lower in galaxies with centrally concentrated gas distributions and higher in galaxies with CO emission dispersed around the galactic center in rings and peaks. The 13CO/12CO J=2-1 line ratios are similar for all galaxies, which indicates that the J=3-2/J=2-1 line ratio is tracing variations in gas temperature and density, rather than variations in optical depth. There is evidence that the galaxies which contain more centralized CO distributions are comprised of molecular gas that is cooler and less dense. Observations suggest that the star formation rates are higher in the galaxies containing the warmer, denser, less centrally concentrated gas. It is possible that either the bar dynamics are responsible for the variety of gas distributions and densities (and hence the star formation rates) or that the star formation alone is responsible for modifying the gas properties.Comment: 27 pages + 6 figures; to appear in the April 20, 2003 issue of Ap

7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects

Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction. Recently, growing use of the plant in the United States and concerns that kratom represents an uncontrolled drug with potential abuse liability, have highlighted the need for more careful study of its pharmacological activity. The major active alkaloid found in kratom, mitragynine, has been reported to have opioid agonist and analgesic activity in vitro and in animal models, consistent with the purported effects of kratom leaf in humans. However, preliminary research has provided some evidence that mitragynine and related compounds may act as atypical opioid agonists, inducing therapeutic effects such as analgesia, while limiting the negative side effects typical of classical opioids. Here we report evidence that an active metabolite plays an important role in mediating the analgesic effects of mitragynine. We find that mitragynine is converted in vitro in both mouse and human liver preparations to the much more potent mu-opioid receptor agonist 7-hydroxymitragynine, and that this conversion is mediated by cytochrome P450 3A isoforms. Further, we show that 7-hydroxymitragynine is formed from mitragynine in mice and that brain concentrations of this metabolite are sufficient to explain most or all of the opioid-receptor-mediated analgesic activity of mitragynine. At the same time, mitragynine is found in the brains of mice at very high concentrations relative to its opioid receptor binding affinity, suggesting that it does not directly activate opioid receptors. The results presented here provide a metabolism-dependent mechanism for the analgesic effects of mitragynine and clarify the importance of route of administration for determining the activity of this compound. Further, they raise important questions about the interpretation of existing data on mitragynine and highlight critical areas for further research in animals and humans.</p

OH Satellite Line Masers and an AGN Candidate in M82

We report the detection of OH satellite line masers at 1720 MHz and 1612 MHz from the nuclear region of the starburst galaxy M82. The observations were aimed at detecting 1720 MHz maser emission from the known radio emitting SNR in the nuclear region. At 1720 MHz we detect six features above the 5-sigma limit set by noise, four in emission and two in absorption. Three of the emission features appear closely associated with known discrete continuum radio sources, and one of the absorption features is precisely coincident with the discrete continuum source 44.01+59.6. The latter source also exhibits strong 1612 MHz emission at the same velocity. No other 1612 MHz features were detected. All of the 1720 MHz emission features are consistent with masers pumped by collisions with molecular hydrogen at densities between 10^3 cm^{-3} and 10^5 cm^{-3}, and T_k between 50 K and 250 K. The absorption and emission associated with the two satellite lines in 44.01+59.6, together with other evidence, points to the possibility that this source is the AGN in M82.Comment: accepted ApJ

High-excitation OH and H_2O lines in Markarian 231: the molecular signatures of compact far-infrared continuum sources

The ISO/LWS far-infrared spectrum of the ultraluminous galaxy Mkn 231 shows OH and H_2O lines in absorption from energy levels up to 300 K above the ground state, and emission in the [O I] 63 micron and [C II] 158 micron lines. Our analysis shows that OH and H_2O are radiatively pumped by the far-infrared continuum emission of the galaxy. The absorptions in the high-excitation lines require high far-infrared radiation densities, allowing us to constrain the properties of the underlying continuum source. The bulk of the far-infrared continuum arises from a warm (T_dust=70-100 K), optically thick (tau_100micron=1-2) medium of effective diameter 200-400 pc. In our best-fit model of total luminosity L_IR, the observed OH and H2O high-lying lines arise from a luminous (L/L_IR~0.56) region with radius ~100 pc. The high surface brightness of this component suggests that its infrared emission is dominated by the AGN. The derived column densities N(OH)>~10^{17} cm^{-2} and N(H_2O)>~6x10^{16} cm^{-2} may indicate XDR chemistry, although significant starburst chemistry cannot be ruled out. The lower-lying OH, [C II] 158 micron, and [O I] 63 micron lines arise from a more extended (~350 pc) starburst region. We show that the [C II] deficit in Mkn 231 is compatible with a high average abundance of C+ because of an extreme overall luminosity to gas mass ratio. Therefore, a [C II] deficit may indicate a significant contribution to the luminosity by an AGN, and/or by extremely efficient star formation.Comment: 16 pages, 6 figures, accepted for publication in The Astrophysical Journa

Cold and warm dust along a merging galaxy sequence

We investigate the cold and warm dust properties during galaxy interactions using a merging galaxy sample ordered into a chronological sequence from pre- to post-mergers. Our sample comprises a total of 29 merging systems selected to have far-infrared and sub-millimeter observations. The sub-millimeter data are mainly culled from the literature while for 5 galaxies (NGC 3597, NGC 3690, NGC 6090, NGC 6670 and NGC 7252) the sub-millimeter observations are presented here for the first time. We use the 100-to-850 micron flux density ratio, f_{100}/f_{850}, as a proxy to the mass fraction of the warm and the cold dust in these systems. We find evidence for an increase in f_{100}/f_{850} along the merging sequence from early to advanced mergers and interpret this trend as an increase of the warm relative to the cold dust mass. We argue that the two key parameters affecting the f_{100}/f_{850} flux ratio is the star-formation rate and the dust content of individual systems relative to the stars. Using a sophisticated model for the absorption and re-emission of the stellar UV radiation by dust we show that these parameters can indeed explain both the increase and the observed scatter in the f_{100}/f_{850} along the merging galaxy sequence. We also discuss our results under the hypothesis that elliptical galaxies are formed via disc galaxy mergers.Comment: Accepted for publication in MNRA