Spectral UV measurements in Austria from 1994 to 2006: investigations of short- and long-term changes

The influence of variability of atmospheric parameters on short- and long-term changes of spectral UV irradiance measured at the Sonnblick observatory (47.03° N, 12.57° E, 3106 m) during the period from 1994 to 2006 is studied. Measurements were performed with the Brewer #093 single-monochromator spectrophotometer and with a Bentham DM 150 spectroradiometer (double-monochromator). <br> <br> The influence of ozone, albedo, snowline and clouds on UV variability is evaluated for each parameter separately using 10-year climatology. It is found that the effect of total ozone on short-term variability of UV irradiance at 305 nm can be more than 200% and on average more than 50%. Clouds can cause variability of 150% or more and on average 35%. Variability caused by albedo reaches a maximum of 32% in April (6% on average). In summer and autumn, total ozone and clouds strongly influence the variability of UV radiation, whereas in winter and spring ozone has the more pronounced effect. A decrease in snowline height from 3000 m to 800 m a.s.l. enhances the UV irradiance by a factor of 1.24 for clear sky conditions and by a factor of 1.7 for 8/8 cloud cover. <br> <br> Long-term trends are investigated for the time period from 1994 to 2006 based on clear-sky measurements, using the non-parametric Mann-Kendall trend test. Significant downward trends (99% confidence level) are found for solar zenith angle 55° at wavelengths from 305 nm to 324 nm and erythemally weighted irradiance according to CIE, which are caused by an increase in sunshine duration during periods of high total column ozone. Significant trends (90% confidence level) were also found for other combinations of wavelength and SZA

Evaluating inputs for organic farming – a new system. Proposals of the ORGANIC INPUTS EVALUATION project

This volume contains proposals for criteria for evaluation of plant protection products, fertilisers and soil conditioners1 to be used in organic agriculture. These ideas were developed in the course of the European Union (EU) Concerted Action project ‘ORGANIC INPUTS EVALUATION’ (QLK5-CT-2002-02565). For more information on this project see the end of this volume or visit the project website www.organicinputs.org. The documents in this volume are proposals elaborated by the project consortium and external experts. They were discussed with a broader audience at a public conference held in Brussels on October 13, 2005, and have been amended accordingly. Our proposals also include a “criteria matrix”, which is in Microsoft Excel format, and therefore stands as a separate file. The criteria matrix is discussed in section 5, but we strongly recommend that you consult the original document. To illustrate the use of the matrix, we have further prepared two case studies, which are also separate Excel files. All of these files are contained on the CD, and can also be downloaded from the project website. Currently, Regulation 2092/91 is under revision. We hope that our ideas can be incorporated into the regulation during this revision! In addition, we strongly encourage national institutions to make use of our proposals at the national level

Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas (Review)

Background Soft tissue sarcomas (STS) are a highly heterogeneous group of raremalignant solid tumors.Non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) comprise all STS except rhabdomyosarcoma. In patients with advanced local or metastatic disease, autologous hematopoietic stem cell transplantation (HSCT) applied after high-dose chemotherapy (HDCT) is a planned rescue therapy forHDCT-related severe hematologic toxicity. Objectives To assess the effectiveness and safety of HDCT followed by autologous HSCT for all stages of soft tissue sarcomas in children and adults. Search strategy We searched the electronic databases CENTRAL (The Cochrane Library 2010, Issue 2), MEDLINE and EMBASE (February 2010). Online trial registers, congress abstracts and reference lists of reviews were searched and expert panels and authors were contacted. Selection criteria Terms representing STS and autologous HSCT were required in the title, abstract or keywords. In studies with aggregated data, participants with NRSTS and autologous HSCT had to constitute at least 80% of the data. Comparative non-randomized studies were included because randomized controlled trials (RCTs) were not expected. Case series and case reports were considered for an additional descriptive analysis. Data collection and analysis Study data were recorded by two review authors independently. For studies with no comparator group, we synthesised results for studies reporting aggregate data and conducted a pooled analysis of individual participant data using the Kaplan-Meyer method. The primary outcomes were overall survival (OS) and treatment-related mortality (TRM). Main results We included 54 studies, from 467 full texts articles screened (11.5%), reporting on 177 participants that received HSCT and 69 participants that received standard care. Only one study reported comparative data. In the one comparative study, OS at two years after HSCT was estimated as statistically significantly higher (62.3%) compared with participants that received standard care (23.2%). In a single-arm study, the OS two years after HSCT was reported as 20%. In a pooled analysis of the individual data of 54 participants, OS at two years was estimated as 49% (95% CI 34% to 64%). Data on TRM, secondary neoplasia and severe toxicity grade 3 to 4 after transplantation were sparse. All 54 studies had a high risk of bias. Authors’ conclusions Due to a lack of comparative studies, it is unclear whether participants with NRSTS have improved survival from autologous HSCT following HDCT. Owing to this current gap in knowledge, at present HDCT and autologous HSCT for NRSTS should only be used within controlled trials

Evaluating inputs for organic farming - a new system

This CD contains criteria for the evaluation of plant protection products, fertilizers and soil conditioners to be used in organic agriculture. These ideas were developed in the course of the European Union Concerted Action project «ORGANIC INPUTS EVALUATION» (QLK5-CT-2002-02565). For more information visit the project website www.organicinputs.org. The editors gratefully acknowledge financial support from the Commission of the European Communities, under Key Action 5 of the Fifth Framework Programme for Research and Technological Development (QLK5-CT-2002-02565 «ORGANIC INPUTS EVALUATION») and co-funding by the Swiss Federal Office for Education and Science (BBW 02.0113)

Reporting of loss to follow-up information in randomised controlled trials with time-to-event outcomes: a literature survey

<p>Abstract</p> <p>Background</p> <p>To assess the reporting of loss to follow-up (LTFU) information in articles on randomised controlled trials (RCTs) with time-to-event outcomes, and to assess whether discrepancies affect the validity of study results.</p> <p>Methods</p> <p>Literature survey of all issues of the BMJ, Lancet, JAMA, and New England Journal of Medicine published between 2003 and 2005. Eligible articles were reports of RCTs including at least one Kaplan-Meier plot. Articles were classified as "assessable" if sufficient information was available to assess LTFU. In these articles, LTFU information was derived from Kaplan-Meier plots, extracted from the text, and compared. Articles were then classified as "consistent" or "not consistent". Sensitivity analyses were performed to assess the validity of study results.</p> <p>Results</p> <p>319 eligible articles were identified. 187 (59%) were classified as "assessable", as they included sufficient information for evaluation; 140 of 319 (44%) presented consistent LTFU information between the Kaplan-Meier plot and text. 47 of 319 (15%) were classified as "not consistent". These 47 articles were included in sensitivity analyses. When various imputation methods were used, the results of a chi²-test applied to the corresponding 2 × 2 table changed and hence were not robust in about half of the studies.</p> <p>Conclusions</p> <p>Less than half of the articles on RCTs using Kaplan-Meier plots provide assessable and consistent LTFU information, thus questioning the validity of the results and conclusions of many studies presenting survival analyses. Authors should improve the presentation of both Kaplan-Meier plots and LTFU information, and reviewers of study publications and journal editors should critically appraise the validity of the information provided.</p

Nationaler Energie- und Klimaplan (NEKP) für Österreich - Wissenschaftliche Bewertung der in der Konsultation 2023 vorgeschlagenen Maßnahmen [National Energy and Climate Plan (NEKP) for Austria - Scientific assessment of the measures proposed in the 2023 consultation]

Um den globalen Klimawandel zu bremsen, seine Auswirkungen abzumildern und eine nach-haltige Zukunft für junge und zukünftige Generationen zu gestalten, sind internationale Koor-dination sowie umfassende nationale Umsetzungspläne für Klimamaßnahmen unerlässlich. Vor diesem Hintergrund hat das Bundesministerium für Klimaschutz, Umwelt, Energie, Mobi-lität, Innovation und Technologie (BMK) nach Einbindung der relevanten anderen österreichi-schen Bundesministerien Ende Juni 2023 den Entwurf eines integrierten nationalen Energie- und Klimaplans (NEKP) für Österreich (Periode 2021-2030) vorgelegt. Dieser Entwurf stand im Sommer 2023 zur Kommentierung offen, um eine breite Beteiligung von öffentlichen und privaten Institutionen und Personen sicherzustellen. In order to slow down global climate change, mitigate its effects and shape a sustainable future for young and future generations, international coordination and comprehensive national implementation plans for climate measures are essential. Against this background, the Federal Ministry for Climate Protection, Environment, Energy, Mobility, Innovation and Technology (BMK), after involving the relevant other Austrian federal ministries, presented the draft of an integrated national energy and climate plan (NEKP) for Austria at the end of June 2023 ( Period 2021-2030). This draft was open for comment in summer 2023 to ensure broad participation from public and private institutions and individuals

Towards a life cycle sustainability assessment method for the quantification and reduction of impacts of buildings life cycle

The construction and building sectorsare one of the highestconsumersof resourcesand energy. Literature evidences the potentialities of the design phase towardsthe improvement of environmental, economic and social performance of buildings. Thus, the Life Cycle Sustainability Assessment (LCSA) approach is recognized as suitable method. It isbased on the “triple bottom line”principle, to calculate environmental, economic, social impacts produced by buildings during itslife cycle. The present paper aims to present a methodological framework based on anLCSA, used during design stages of buildings and integrated into a building’s design technology such as Building Information Modeling (BIM). A conceptual approach to conduct the data integration and a possible workflow to integrate the LCSA into BIMis proposed. The value of the present approach is the possibility to conductquantitative environmental, economic and social assessment of buildings to guide designers to measure and predict the building’s performanc

Bacterial Gut Symbionts Contribute to Seed Digestion in an Omnivorous Beetle

Obligate bacterial symbionts alter the diets of host animals in numerous ways, but the ecological roles of facultative bacterial residents that colonize insect guts remain unclear. Carabid beetles are a common group of beneficial insects appreciated for their ability to consume insect prey and seeds, but the contributions of microbes to diet diversification in this and similar groups of facultative granivores are largely unknown.Using 16S rRNA gene clone libraries and terminal restriction fragment (tRF) length polymorphism analyses of these genes, we examined the bacterial communities within the guts of facultatively granivorous, adult Harpalus pensylvanicus (Carabidae), fed one of five dietary treatments: 1) an untreated Field population, 2) Seeds with antibiotics (seeds were from Chenopodium album), 3) Seeds without antibiotics, 4) Prey with antibiotics (prey were Acheta domesticus eggs), and 5) Prey without antibiotics. The number of seeds and prey consumed by each beetle were recorded following treatment. Harpalus pensylvanicus possessed a fairly simple gut community of approximately 3-4 bacterial operational taxonomic units (OTU) per beetle that were affiliated with the Gammaproteobacteria, Bacilli, Alphaproteobacteria, and Mollicutes. Bacterial communities of the host varied among the diet and antibiotic treatments. The field population and beetles fed seeds without antibiotics had the closest matching bacterial communities, and the communities in the beetles fed antibiotics were more closely related to each other than to those of the beetles that did not receive antibiotics. Antibiotics reduced and altered the bacterial communities found in the beetle guts. Moreover, beetles fed antibiotics ate fewer seeds, and those beetles that harbored the bacterium Enterococcus faecalis consumed more seeds on average than those lacking this symbiont.We conclude that the relationships between the bacterium E. faecalis and this factultative granivore's ability to consume seeds merit further investigation, and that facultative associations with symbiotic bacteria have important implications for the nutritional ecology of their hosts