Exercise in the Heat: Perceptual Measures in Hydrated and Dehydrated Conditions

Introduction: Athletes, warfighters, and laborers are often exposed to extreme environmental conditions that can result in heat-related illnesses negatively impacting performance and productivity. Purpose: To evaluate Total Mood Disturbance (TMD) from pre-trial to post-trial surrounding exercise in the heat. The secondary purpose was to compare post-trial measures between hydration status as well as environmental conditions. Methods: Twenty-six male and female subjects performed four trials. Two trials were conducted in temperate conditions (24 ℃, 55% relative humidity) and two in extreme heat conditions (35 ℃, 55% relative humidity), in both hydrated and dehydrated conditions. The Profile of Moods States survey was administered before and after each trial; TMD was calculated for each timepoint. Descriptive statistics (mean ± SD) were calculated, and Mann-Whitney U t-tests were utilized to compare TMD pre-trial vs. post-trial measures for each condition, post-trial hydrated vs. post-trial dehydrated for each environmental condition, and post-trial temperate vs. post-trial extreme heat for both hydration statuses. Results: In the temperate hydrated, temperate dehydrated, and extreme heat dehydrated conditions, there were no significant differences between pre-trial and post-trial TMD (p=0.276; p=0.237; p=0.322). In the extreme heat hydrated condition, there were significant differences between pre-trial and post-trial TMD (p=0.049). There were no significant differences between post-trial TMD between environmental conditions or hydration statuses (p\u3e0.05)

Impact of a Library Instruction Session on Bibliographies of Organic Chemistry Students

Students in Chemistry 254: Organic Chemistry for Majors were required to write a paper about an organic name reaction (a reaction named after the chemist who discovered it). Before turning in this assignment, students had the option of attending a one-hour library instruction session covering SciFinder, sources for spectra, ACS Style, and print resources about organic name reactions. 25 students attended library sessions while 30 did not. Bibliographies were collected and graded for all students. Comparisons were made between those students who attended the session and those who did not, on such criteria as use of scholarly sources, properly citing articles and spectra, and correct use of ACS Style. Students achieved 14% higher bibliography scores (82% vs. 68%) by attending a library session, used more scholarly sources (96% of sources scholarly vs. 81% for non-attendees), and used spectra from appropriate sources better (86% of attendees vs. 32% for non-attendees). ACS Style proved difficult for session attendees and non-attendees alike

A Copperhead

The Civil War-era carte de visite features a caricature depicting William B. Reed as a Copperhead. Reed, a politician and lawyer from Pennsylvania, held pro-Confederacy views which were in conflict with many of his political peers. In the cartoon, Reed\u27s head has been mounted to the body of a snake.https://scholarsjunction.msstate.edu/fvw-cdv/1574/thumbnail.jp

The New Zealand Kauri (Agathis Australis) Research Project: A Radiocarbon Dating Intercomparison of Younger Dryas Wood and Implications for IntCal13

We describe here the New Zealand kauri (Agathis australis) Younger Dryas (YD) research project, which aims to undertake Δ14C analysis of ~140 decadal floating wood samples spanning the time interval ~13.1–11.7 kyr cal BP. We report 14C intercomparison measurements being undertaken by the carbon dating laboratories at University of Waikato (Wk), University of California at Irvine (UCI), and University of Oxford (OxA). The Wk, UCI, and OxA laboratories show very good agreement with an interlaboratory comparison of 12 successive decadal kauri samples (average offsets from consensus values of –7 to +4 14C yr). A University of Waikato/University of Heidelberg (HD) intercomparison involving measurement of the YD-age Swiss larch tree Ollon505, shows a HD/Wk offset of ~10–20 14C yr (HD younger), and strong evidence that the positioning of the Ollon505 series is incorrect, with a recommendation that the 14C analyses be removed from the IntCal calibration database

IntCal09 and Marine09 radiocarbon age calibration curves, 0-50,000yeats cal BP

The IntCal04 and Marine04 radiocarbon calibration curves have been updated from 12 cal kBP (cal kBP is here defined as thousands of calibrated years before AD 1950), and extended to 50 cal kBP, utilizing newly available data sets that meet the IntCal Working Group criteria for pristine corals and other carbonates and for quantification of uncertainty in both the 14C and calendar timescales as established in 2002. No change was made to the curves from 0–12 cal kBP. The curves were constructed using a Markov chain Monte Carlo (MCMC) implementation of the random walk model used for IntCal04 and Marine04. The new curves were ratified at the 20th International Radiocarbon Conference in June 2009 and are available in the Supplemental Material at www.radiocarbon.org

Decadally resolved lateglacial radiocarbon evidence from New Zealand kauri

Author Posting. © The Author(s), 2016. This is the author's version of the work. It is posted here by permission of Arizona Board of Regents on behalf of the University of Arizona for personal use, not for redistribution. The definitive version was published in Radiocarbon 58 (2016): 709-733, doi: 10.1017/RDC.2016.86.The Last Glacial-Interglacial Transition (LGIT; 15,000-11,000 cal BP) was characterized by complex spatiotemporal patterns of climate change, with numerous studies requiring accurate chronological control to decipher leads from lags in global paleoclimatic, -environmental and archaeological records. However, close scrutiny of the few available tree-ring chronologies and 14C-dated sequences composing the IntCal13 radiocarbon calibration curve, indicates significant weakness in 14C calibration across key periods of the LGIT. Here, we present a decadally-resolved atmospheric 14C record derived from New Zealand kauri spanning the Lateglacial from ~13,100 - 11,365 cal BP. Two floating kauri 14C time series, curve-matched to IntCal13, serve as a radiocarbon backbone through the Younger Dryas. The floating Northern Hemisphere (NH) 14C datasets derived from the YD-B and Central European Lateglacial Master tree-ring series are matched against the new kauri data, forming a robust NH 14C time series to ~14,200 cal BP. Our results show that IntCal13 is questionable from ~12,200 - 11,900 cal BP and the ~10,400 BP 14C plateau is approximately five decades too short. The new kauri record and re-positioned NH pine 14C series offer a refinement of the international 14C calibration curves IntCal13 and SHCal13, providing increased confidence in the correlation of global paleorecords.This work was part funded by the Foundation for Research, Science and Technology (FRST)—now Ministry for Business, Innovation & Employment (MBIE)-PROP-20224-SFK-UOA), a Royal Society of New Zealand grant, the Australian Research Council (FL100100195 and DP0664898) and the Natural Environment Research Council (NE/H009922/1, NE/I007660/1, NER/A/S/2001/01037 and NE/H007865/1)

On the fate of the secondary white dwarf in double-degenerate double-detonation Type Ia supernovae

The progenitor systems and explosion mechanism of Type Ia supernovae are still unknown. Currently favoured progenitors include double-degenerate systems consisting of two carbon-oxygen white dwarfs with thin helium shells. In the double-detonation scenario, violent accretion leads to a helium detonation on the more massive primary white dwarf that turns into a carbon detonation in its core and explodes it. We investigate the fate of the secondary white dwarf, focusing on changes of the ejecta and observables of the explosion if the secondary explodes as well rather than survives. We simulate a binary system of a $1.05\,M_\odot$ and a $0.7\,M_\odot$ carbon-oxygen white dwarf with $0.03\,M_\odot$ helium shells each. We follow the system self-consistently from inspiral to ignition, through the explosion, to synthetic observables. We confirm that the primary white dwarf explodes self-consistently. The helium detonation around the secondary white dwarf, however, fails to ignite a carbon detonation. We restart the simulation igniting the carbon detonation in the secondary white dwarf by hand and compare the ejecta and observables of both explosions. We find that the outer ejecta at $v>15000\,\mathrm{km\,s^{-1}}$ are indistinguishable. Light curves and spectra are very similar until $\sim 40$d after explosion and the ejecta are much more spherical than for violent merger models. The inner ejecta differ significantly which slows down the decline rate of the bolometric light curve after maximum of the model with a secondary explosion by about 20 per cent. We expect future synthetic 3D nebular spectra to confirm or rule out either model.Comment: 12 pages, 7 figures, submitted to MNRAS, comments welcom

The potential for an independent source of Younger Dryas tree-ring radiocarbon data from the Lake Ontario region, North America, and its palaeoenvironmental context

Tree rings are the gold standard for the calibration of radiocarbon dates into calendar years with limited error due to their annual record of radiocarbon content in the atmosphere. Currently, the tree-ring 14C data used in the International Radiocarbon Calibration curve (IntCal13) are from multiple sources back to ~ 10 ka cal BP for the northern hemisphere. However, the source for tree-ring calibration data prior to ~10 ka cal BP, including the Younger Dryas (YD) and most of the Early Holocene (EH) chronozones, is limited to central Europe. Substantial quantities of logs found in the lowlands of Lake Ontario in North America, dating from 12.1 to 11.2 ka cal BP, have great potential for providing unique YD-EH tree-ring 14C data from a new, previously unrepresented, geographic location and for adding a new perspective to ongoing debates such as the timing of the YD/EH transition in continental North America. Preliminary fieldwork yielded over 43 logs, predominantly spruce (Picea spp.), found buried in alluvial strata over 0.2 hectares of the floodplain at Bell Creek near Fulton, NY. Dendrochronological analysis of 32 spruce logs from this collection has produced several chronologies, one 183 years in length and a second of 147 years with a possible crossdate yielding a chronology of 260 years. Ongoing survey of the site suggests that there is high preservation potential in the same stratigraphic units in an additional ~2 hectares of floodplain, and sample collection with subsequent analysis will increase the chronology’s sample depth, extend its length, and potentially provide a robust, independent Younger Dryas – Early Holocene 14C record. Initial assessments of climatic, hydrological, environmental, and isostatic variations and events over time from the tree rings and their stable isotopes, as well as pollen, macrofossil, and sediment analyses and isostatic modeling indicate substantial changes in the Bell Creek Valley and surrounding lowlands both during the YD and into the mid-Holocene. These changes include significant alterations in the rate, volume, and direction of stream flow, and transition from a boreal riparian environment on a low-order river to a wetlands, then back to a riparian environment with much less streamflow and occasional flooding, similar to the Bell Creek Valley today

Regulation of Thromboxane Receptor Signaling at Multiple Levels by Oxidative Stress-Induced Stabilization, Relocation and Enhanced Responsiveness

Thromboxane A(2) (TxA(2)) is a major, unstable arachidonic acid metabolite, and plays a key role in normal physiology and control of vascular tone. The human thromboxane receptor (TPβ), expressed in COS-7 cells, is located predominantly in the endoplasmic reticulum (ER). Brief hydrogen peroxide exposure increases the efficiency of translocation of TPβ from the ER into the Golgi complex, inducing maturation and stabilization of TPβ. However, the ultimate fate of this post-ER TPβ pool is not known, nor is its capacity to initiate signal transduction. Here we specifically assessed if functional TPβ was transported to the plasma membrane following H(2)O(2) exposure.We demonstrate, by biotinylation and confocal microscopy, that exposure to H(2)O(2) results in rapid delivery of a cohort of TPβ to the cell surface, which is stable for at least eight hours. Surface delivery is brefeldin A-sensitive, indicating that translocation of this receptor cohort is from internal pools and via the Golgi complex. H(2)O(2) treatment results in potentiation of the increase to intracellular calcium concentrations in response to TPβ agonists U46619 and 8-iso PGF(2α) and also in the loss of ligand-dependent receptor internalization. Further there is increased responsiveness to a second application of the agonist. Finally we demonstrate that the effect of H(2)O(2) on stimulating surface delivery is shared with the FP prostanoid receptor but not the EP3 or EP4 receptors.In summary, brief exposure to H(2)O(2) results in an immediate and sustained increase in the surface pool of thromboxane receptor that is capable of mediating a persistent hyper-responsiveness of the cell and suggests a highly sophisticated mechanism for rapidly regulating thromboxane signaling

Development of the IntCal database

The IntCal family of radiocarbon (14C) calibration curves is based on research spanning more than three decades. The IntCal group have collated the 14C and calendar age data (mostly derived from primary publications with other types of data and meta-data) and, since 2010, made them available for other sorts of analysis through an open-access database. This has ensured transparency in terms of the data used in the construction of the ratified calibration curves. As the IntCal database expands, work is underway to facilitate best practice for new data submissions, make more of the associated metadata available in a structured form, and help those wishing to process the data with programming languages such as R, Python, and MATLAB. The data and metadata are complex because of the range of different types of archives. A restructured interface, based on the “IntChron” open-access data model, includes tools which allow the data to be plotted and compared without the need for export. The intention is to include complementary information which can be used alongside the main 14C series to provide new insights into the global carbon cycle, as well as facilitating access to the data for other research applications. Overall, this work aims to streamline the generation of new calibration curves