(E)-N-Benzyl­idene-4H-1,2,4-triazol-4-amine

The title compound, C9H8N4, crystallizes with three independent mol­ecules (A, B and C) per asymmetric unit. The independent mol­ecules differ slightly in their conformations, the dihedral angles between the triazole and phenyl rings in mol­ecules A, B and C being 4.8 (2), 9.7 (2) and 7.2 (2)°, respectively. In the crystal, the independent mol­ecules are linked into a trimer by C—H⋯N hydrogen bonds

N-[(E)-2-Chloro­benzyl­idene]-3-(4-methyl­benzyl­sulfan­yl)-5-(3,4,5-trimethoxy­phen­yl)-4H-1,2,4-triazol-4-amine

In the title compound, C26H25ClN4O3S, the acyclic imine group exhibits an E configuration. The triazole ring is oriented at dihedral angles of 53.84 (2), 70.77 (1) and 32.59 (3)° with respect to the benzene rings of the 2-chloro­benzyl­idene, 4-methyl­benzyl­sulfanyl and 3,4,5-trimethoxy­phenyl groups, respectively. The crystal packing is stabilized by weak inter­molecular C—H⋯N, C—H⋯S and C—H⋯π inter­actions

5-(2-Methoxy­benz­yl)-4-(2-methoxy­phen­yl)-4H-1,2,4-triazol-3-ol

In the mol­ecule of the title compound, C17H17N3O3, the triazole ring is oriented at dihedral angles of 88.09 (3) and 83.72 (3)° with respect to the 2-methoxy­benzyl and 2-methoxy­phenyl rings, respectively. The dihedral angle between the 2-methoxy­benzyl and 2-methoxy­phenyl rings is 52.95 (3)°. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into centrosymmetric dimers. There is a π–π contact between the 2-methoxy­phenyl rings [centroid–centroid distance = 3.811 (3) Å]

4-(4-Methoxy­phen­yl)-3-[2-(2-methoxy­phen­yl)eth­yl]-1H-1,2,4-triazol-5(4H)-one

The title compound, C18H19N3O3, is a biologically active triazole derivative. The five-membered ring is oriented with respect to the six-membered rings at dihedral angles of 51.59 (4) and 61.37 (4)°. The crystal structure is stabilized by inter­molecular N—H⋯O hydrogen-bond inter­actions between centrosymmetrically related mol­ecules [the dihedral angle between the benzene rings is 47.44 (5)°]

Plantas nativas del Norte Argentino : aplicación en el control de bacterias fitopatógenas

Las enfermedades bacterianas generan pérdidas económicas importantes en los cultivos. En la actualidad se aplican en forma preventiva compuestos cúpricos para disminuir a incidencia de las mismas. El noroeste argentino posee una enorme biodiversidad en sus plantas medicinales que constituyen una potencial fuente de nuevos metabolitos bioactivos. En este contexto, el objetivo del trabajo fue identificar y cuantificar la actividad antibacteriana de extractos de plantas nativas del noroeste argentino sobre bacterias fitopatógenas de importancia agrícola. Para ello se recolectaron partes aéreas de plantas nativas del noroeste argentino. Hojas y tallos de Aspidosperma quebracho-blanco, Schinus fasciculatus, S. gracilipes, Amphilophium cynanchoides y Tecoma stans fueron separados y extraídos con solventes de polaridad creciente para obtener extractos de diclorometano (fCH2Cl2), acetato de etilo (fAcEt) y metanol (fMeOH), respectivamente. Entre los treinta extractos analizados solo los fAcEt a partir de hojas y tallos de S. fasciculatus inhibieron a las cinco cepas bacterianas ensayadas, Pseudomonas syringae pv tomato Pseudomonas corrugata, Xanthomonas campestres pv vesicatoria, Erwinia carotovora var carotovora y Agrobacterium tumefaciens (CI50 = 0.9 mg/ml). Se identificaron y cuantificó la ctividad antibacteriana de tres componentes de estos extractos: kaempferol (CIM= 250 μg/ml, CECT 124 y 472; CIM=500 μg/ml, CECT 126 y 792), quercetina (CIM = 1000 μg/ml, CECT 124, 126 y 792; CIM= 2000 ppm, CECT 472) y agathisflavona (CIM = 2000 μg/ml; CECT 126 y 792). El extracto fAcEt de S. fasciculatus y los flavonoides mostraron efectos sinérgicos y aditivos en las cepas bacterianas en combinación con kocideFil: Terán Baptista, Zareath P. . Université de Paris.Fil: Kritsanida, Marina. Université de Paris.Fil: Grougnetb, Raphael . Université de Paris.Fil: Sampietro, Diego A. . Université de Paris

4-(2-Methoxy­phenyl)-3-(3,4,5-tri­methoxy­phen­ethyl)-2H-1,2,4-triazole-5(4H)-thione

The title compound, C20H23N3O4S, is an important biologically active heterocyclic compound. The five-membered ring is oriented with respect to the six-membered rings at dihedral angles of 78.60 (3) (trimethoxyphenyl ring) and 71.57 (3)° (methoxyphenyl ring). In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into infinite chains along the c axis

N-[4-Acetyl-5-(2-methylprop-1-enyl)-5-(2-p-tolyl­prop­yl)-4,5-dihydro-1,3,4-thia­diazol-2-yl]acetamide

The title heterocyclic compound, C20H27N3O2S, was synthesized from 2-(4-methyl­cyclo­hex-3-en­yl)-6-methyl­hepta-2,5-dien-4-one, which was isolated from the essential oil Cedrus atlantica. The thia­diazole ring is essentially planar [maximum deviation 0.006 (2) Å] and it forms a dihedral angle of 18.08 (9)° with the benzene ring. The dihedral angle between the thia­diazole ring and the acetamide plane is 7.62 (10)°. In the crystal, mol­ecules are linked into chains running along the c axis by inter­molecular N—H⋯O hydrogen bonds

5-(3-Methoxy­pheneth­yl)-4-(2-methoxy­phen­yl)-4H-1,2,4-triazol-3-ol

In the mol­ecule of the title compound, C18H19N3O3, the triazole ring is oriented with respect to the 3-methoxy­phenyl and 2-methoxy­phenyl rings at dihedral angles of 11.79 (3) and 89.22 (3)°, respectively. The dihedral angle between the two benzene rings is 85.95 (3)°. In the crystal structure, inter­molecular O—H⋯N and C—H⋯O hydrogen bonds link the mol­ecules. There is a π–π contact between the triazole and 3-methoxy­phenyl rings [centroid–centroid distance = 3.916 (3) Å]. There is a π–π contact between the triazole and one of the 3-methoxy­phenyl rings [centroid–centroid distance = 3.916 (3) Å ]. C—H⋯π contacts are also found between the benzene ring and the methyl groups of their 3-methoxy-substituents

3-(3-Methoxy­benz­yl)-4-(2-methoxy­phen­yl)-1H-1,2,4-triazole-5(4H)-thione

In the title compound, C17H17N3O2S, the five-membered ring forms dihedral angles of 53.02 (3) and 78.57 (3)° with the 3-meth­oxy-substituted and 2-meth­oxy-substituted benzene rings, respectively. In the crystal structure, mol­ecules are linked into centrosymmetric dimers via inter­molecular N—H⋯S hydrogen bonds

N-[(4-Amino-5-sulfanyl­idene-4,5-dihydro-1H-1,2,4-triazol-3-yl)meth­yl]-4-methyl­benzamide

In the title compound, C11H13N5OS, the dihedral angle between the triazole ring and the benzene ring is 84.21 (7)°. The amino group adopts a pyramidal configuration. An intra­molecular N—H⋯O hydrogen bond stabilizes the mol­ecular structure and generates an S(8) ring. In the crystal, mol­ecules are linked by inter­molecular N—H⋯O, N—H⋯S, N—H⋯N and C—H⋯S hydrogen bonds into layers lying parallel to the bc plane. The crystal structure is further stabilized by aromatic π–π stacking inter­actions [centroid–centroid distance = 3.3330 (7) Å]