Correlation Between Coping Strategies and Quality of Life Among Myocardial Infarction Patients in Nepal

Objective: To examine the correlation between coping strategies and quality of life (QoL) among patients with myocardial infarction (MI) Method: A descriptive correlational design was used to examine the relationship between coping strategies and QoL among 88 patients with MI who were older than 18 years, 2 months after the initial diagnosis of MI. QoL was assessed using the cardiac version of the Quality of Life Index. Coping strategy was assessed using Jalowiec Coping Scale. Problem-focused coping and emotion-focused coping were also compared in male and female patients.Results: Problem-focused coping was significantly positively associated with overall QoL (r = .41, p = <.01), particularly the health and functioning dimension (rs = .39, p = <.01) and socio-economic dimension (rs = .46, p = <.01) but not with psychological & spiritual and family dimension. Men used more problem-focused coping strategies than women. The problem-focused coping score was significantly different between men and women (t = 4.9, p <.05).Conclusion: The results revealed that patients who used more of problem-focused coping had better QoL than patients who used less problem-focused coping. Educating patients to enhance the use of appropriate coping strategies may be useful to promote the QoL of Nepalese patients with MI

WT1 gene expression as a prognostic marker in advanced serous epithelial ovarian carcinoma: an immunohistochemical study

BACKGROUND: WT1 is a tumor suppressor gene responsible for Wilms' tumor. WT1 reactivity is limited to ovarian serous carcinomas. Recent studies have shown that WT1 plays an important role in the progression of disease and indicates a poorer prognosis of human malignancies such as acute myeloid leukemia and breast cancer. The aims of this study were to determine the survival and recurrence-free survival of women with advanced serous epithelial ovarian carcinoma in relation to WT1 gene expression. METHODS: The study accrued women over an 18-year period, from 1987–2004. During the study period, 163 patients were diagnosed with advanced serous epithelial ovarian carcinoma and had undergone complete post-operative chemotherapy, but the final study group comprised 99 patients. The records of these women were reviewed and the paraffin-embedded tissue of these women stained with WT1 immunostaining. Survival analysis was performed using Kaplan-Meier and Cox regression methods. RESULTS: Fifty patients showed WT1 staining and forty-nine did not. Five-year survival of non-staining and staining groups were 39.4% and 10.7% (p < 0.00005); five-year recurrence-free survival of these groups were 29.8% and ≤ 7.5% (p < 0.00005), respectively. For survival the HR of WT1 staining, adjusted for residual tumor and chemotherapy response, was 1.98 (95% CI 1.28–3.79), and for recurrence-free survival the HR was 3.36 (95% CI 1.60–7.03). The HR for recurrence-free survival was not confounded by any other variables. CONCLUSION: This study suggests that expression of WT1 gene may be indicative of an unfavorable prognosis in patients with advanced serous epithelial ovarian carcinoma