Response to the letter to the editor: Venous oxygen saturation is reduced and variable in central retinal vein occlusion

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Clinical spectrum of coronavirus disease 2019 in Iceland: population based cohort study.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadObjective: To characterise the symptoms of coronavirus disease 2019 (covid-19). Design: Population based cohort study. Setting: Iceland. Participants: All individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse transcription polymerase chain reaction (RT-PCR) between 17 March and 30 April 2020. Cases were identified by three testing strategies: targeted testing guided by clinical suspicion, open invitation population screening based on self referral, and random population screening. All identified cases were enrolled in a telehealth monitoring service, and symptoms were systematically monitored from diagnosis to recovery. Main outcome measures: Occurrence of one or more of 19 predefined symptoms during follow-up. Results: Among 1564 people positive for SARS-CoV-2, the most common presenting symptoms were myalgia (55%), headache (51%), and non-productive cough (49%). At the time of diagnosis, 83 (5.3%) individuals reported no symptoms, of whom 49 (59%) remained asymptomatic during follow-up. At diagnosis, 216 (14%) and 349 (22%) people did not meet the case definition of the Centers for Disease Control and Prevention and the World Health Organization, respectively. Most (67%) of the SARS-CoV-2-positive patients had mild symptoms throughout the course of their disease. Conclusion: In the setting of broad access to RT-PCR testing, most SARS-CoV-2-positive people were found to have mild symptoms. Fever and dyspnoea were less common than previously reported. A substantial proportion of SARS-CoV-2-positive people did not meet recommended case definitions at the time of diagnosis

Development of a prognostic model of COVID-19 severity : a population-based cohort study in Iceland

© 2022. The Author(s).BACKGROUND: The severity of SARS-CoV-2 infection varies from asymptomatic state to severe respiratory failure and the clinical course is difficult to predict. The aim of the study was to develop a prognostic model to predict the severity of COVID-19 in unvaccinated adults at the time of diagnosis. METHODS: All SARS-CoV-2-positive adults in Iceland were prospectively enrolled into a telehealth service at diagnosis. A multivariable proportional-odds logistic regression model was derived from information obtained during the enrollment interview of those diagnosed between February 27 and December 31, 2020 who met the inclusion criteria. Outcomes were defined on an ordinal scale: (1) no need for escalation of care during follow-up; (2) need for urgent care visit; (3) hospitalization; and (4) admission to intensive care unit (ICU) or death. Missing data were multiply imputed using chained equations and the model was internally validated using bootstrapping techniques. Decision curve analysis was performed. RESULTS: The prognostic model was derived from 4756 SARS-CoV-2-positive persons. In total, 375 (7.9%) only required urgent care visits, 188 (4.0%) were hospitalized and 50 (1.1%) were either admitted to ICU or died due to complications of COVID-19. The model included age, sex, body mass index (BMI), current smoking, underlying conditions, and symptoms and clinical severity score at enrollment. On internal validation, the optimism-corrected Nagelkerke's R2 was 23.4% (95%CI, 22.7-24.2), the C-statistic was 0.793 (95%CI, 0.789-0.797) and the calibration slope was 0.97 (95%CI, 0.96-0.98). Outcome-specific indices were for urgent care visit or worse (calibration intercept -0.04 [95%CI, -0.06 to -0.02], Emax 0.014 [95%CI, 0.008-0.020]), hospitalization or worse (calibration intercept -0.06 [95%CI, -0.12 to -0.03], Emax 0.018 [95%CI, 0.010-0.027]), and ICU admission or death (calibration intercept -0.10 [95%CI, -0.15 to -0.04] and Emax 0.027 [95%CI, 0.013-0.041]). CONCLUSION: Our prognostic model can accurately predict the later need for urgent outpatient evaluation, hospitalization, and ICU admission and death among unvaccinated SARS-CoV-2-positive adults in the general population at the time of diagnosis, using information obtained by telephone interview.Peer reviewe

Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control study

© 2023. The Author(s).BACKGROUND: Persistent symptoms are common after SARS-CoV-2 infection but correlation with objective measures is unclear. METHODS: We invited all 3098 adults who tested SARS-CoV-2 positive in Iceland before October 2020 to the deCODE Health Study. We compared multiple symptoms and physical measures between 1706 Icelanders with confirmed prior infection (cases) who participated, and 619 contemporary and 13,779 historical controls. Cases participated in the study 5-18 months after infection. RESULTS: Here we report that 41 of 88 symptoms are associated with prior infection, most significantly disturbed smell and taste, memory disturbance, and dyspnea. Measured objectively, cases had poorer smell and taste results, less grip strength, and poorer memory recall. Differences in grip strength and memory recall were small. No other objective measure associated with prior infection including heart rate, blood pressure, postural orthostatic tachycardia, oxygen saturation, exercise tolerance, hearing, and traditional inflammatory, cardiac, liver, and kidney blood biomarkers. There was no evidence of more anxiety or depression among cases. We estimate the prevalence of long Covid to be 7% at a median of 8 months after infection. CONCLUSIONS: We confirm that diverse symptoms are common months after SARS-CoV-2 infection but find few differences between cases and controls in objective parameters measured. These discrepancies between symptoms and physical measures suggest a more complicated contribution to symptoms related to prior infection than is captured with conventional tests. Traditional clinical assessment is not expected to be particularly informative in relating symptoms to a past SARS-CoV-2 infection.Peer reviewe

Gender differences in physical activity in older children and adolescents: the central role of organized sport

Previous studies have generally had limited success in accounting for gender differences in leisure time physical activity. Based on a representative national survey of 3270 Icelandic 6th, 8th and 10th grade students, the study found that girls' lower enrollment in organized sport clubs fully accounts for gender differences in frequency of overall physical activity, and largely accounts for gender differences in frequency of strenuous activity, and weekly hours of overall and strenuous activity (enrollment hypothesis). Furthermore, girls' higher sport club withdrawal rate accounted for a small but significant part of the gender difference in weekly hours of overall activity and frequency of strenuous activity (withdrawal hypothesis). No evidence was found to suggest that different activity levels of boys and girls enrolled in the clubs affected gender differences in levels of overall or strenuous physical activity (activity differential hypothesis). Other independent variables, i.e., perceived importance of sport achievement, sport and exercise related instruction, physical education experiences, and social modeling, did not significantly affect observed gender differences beyond the sport club variables. The meaning of the results, and their implications for gender disparities, health promotion, and future research are discussed.Sport participation Physical activity Exercise Gender Iceland

A clinical case study of a participation intervention method for burn dressing change in two children

To access publisher full text version of this article. Please click on the hyperlink in Additional Link fieldEach year in Iceland, approximately 23 children are hospitalized due to severe burns (Landspitali-University Hospital Database, 2002). Ages range from 3.5 to 16 years. All of these have pain associated with the burn. Severe burns are one of the most painful experiences known to people and well remembered [1]. Minor burns have fewer physiologic consequences than major burns, but may be equally painful during their treatment and healing, such as burn dressing change (BDC) [2]

Adherence to food-based dietary guidelines and evaluation of nutrient intake in 7-year-old children

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldOBJECTIVE: To evaluate the diet of 7-year-old children by comparison with food-based dietary guidelines (FBDG) and reference values for nutrient intake. DESIGN: Food and nutrient intake was assessed by 3 d weighed dietary records of 7-year-olds in six randomly chosen schools in Reykjavik, Iceland. Height and weight were measured. The diet of 165 children (62 % of sample) was evaluated by the Icelandic FBDG and the Nordic reference values (NRV) for nutrient intake. SETTING: Six randomly chosen schools in Reykjavik, Iceland. RESULTS: The FBDG on fruits and vegetables was reached by less than 20 % of the children. A total of 52 % reached the FBDG to eat fish twice a week and 41 % to use vitamin D supplement. The FBDG on dairy was reached by 66 % of the children. Mean intake of SFA gave 13.9 % of the total energy intake (E%), which is higher than the NRV, 9.3E% of MUFA and 3.8E% of PUFA, both lower than the NRV (for all differences P < 0.001). Added sugar gave 12.1E%, which exceeds the upper level (P < 0.001). Fibre intake was 2.1 g/MJ and lower than the NRV (P < 0.001). Mean intake of micronutrients was above the recommended intake (RI), except for iodine, 109.0 mug/d, and vitamin D, 6.1 mug/d, which was lower than the RI (P = 0.006 and P < 0.001, respectively). CONCLUSIONS: Fruit, vegetable, fish and dairy, as well as vitamin D supplement, need to be increased in the diet of 7-year-old children to reach the FBDG and the reference values for nutrient intake. Dietary changes to increase the quality of fat and carbohydrate are needed as well

Sociodemographic and health status predictors of parental role strain: A general population study.

To access publisher's full text version of this article click on the hyperlink belowAims: Numerous studies indicate that stressors associated with parenthood can adversely affect parental well-being and children's psychosocial development. The aim of the study was to analyze sociodemographic differences in parental role strain in the general parental population. Methods: The study is based on a national postal survey of a random sample of 605 Icelandic mothers and fathers of children under 18. Results: Parental role strain was related to young parental age at first birth, female gender, non-married status, age of youngest child, age range of children, number of children in the household, and the parent's own chronic illness. Furthermore, chronic illness or disability of a child was markedly related to higher parental role strain, although the relationship was partly reduced with parental employment. Conclusions: Parental role strain is unevenly distributed in the parental population and varies by sociodemographic and health statuses of parents and children. Understanding and addressing parental role strain could improve parental mental health and help create a family environment that enhances the psychosocial development of children