Effective treatment of experimental acute otitis media by application of volatile fluids into the ear canal

To access publisher version of this article. Please click on the hyperlink in Additional Link fieldTo access full text version of this article. Please click on the hyperlink "View/Open" at the bottom of this pageEssential oils are volatile and can have good antimicrobial activity. We compared the effects of oil of basil (Ocimum basilicum) and essential oil components (thymol, carvacrol, and salicylaldehyde) to those of a placebo when placed in the ear canal of rats with experimental acute otitis media caused by pneumococci or Haemophilus influenzae. Progress was monitored by otomicroscopic examination and middle ear cultures. The treatment with oil of basil or essential oil components cured or healed 56%-81% of rats infected with H. influenzae and 6%-75% of rats infected with pneumococci, compared with 5.6%-6% of rats in the placebo group. Essential oils or their components placed in the ear canal can provide effective treatment of acute otitis media

Molecular benchmarks of a SARS-CoV-2 epidemic.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadA pressing concern in the SARS-CoV-2 epidemic and other viral outbreaks, is the extent to which the containment measures are halting the viral spread. A straightforward way to assess this is to tally the active cases and the recovered ones throughout the epidemic. Here, we show how epidemic control can be assessed with molecular information during a well characterized epidemic in Iceland. We demonstrate how the viral concentration decreased in those newly diagnosed as the epidemic transitioned from exponential growth phase to containment phase. The viral concentration in the cases identified in population screening decreased faster than in those symptomatic and considered at high risk and that were targeted by the healthcare system. The viral concentration persists in recovering individuals as we found that half of the cases are still positive after two weeks. We demonstrate that accumulation of mutations in SARS-CoV-2 genome can be exploited to track the rate of new viral generations throughout the different phases of the epidemic, where the accumulation of mutations decreases as the transmission rate decreases in the containment phase. Overall, the molecular signatures of SARS-CoV-2 infections contain valuable epidemiological information that can be used to assess the effectiveness of containment measures

Pressurization of liquid oxygen containers : progress report no. 8.

http://deepblue.lib.umich.edu/bitstream/2027.42/4234/5/bac0800.0008.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/4234/4/bac0800.0008.001.tx

Pressurization of liquid oxygen containers : progress report

http://deepblue.lib.umich.edu/bitstream/2027.42/4238/5/bac0800.0013.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/4238/4/bac0800.0013.001.tx

Pressurization of liquid oxygen containers : progress report no. 7.

http://deepblue.lib.umich.edu/bitstream/2027.42/4233/5/bac0800.0007.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/4233/4/bac0800.0007.001.tx

A 6-month randomized, double-blind, placebo-controlled trial of weekly exenatide in adolescents with obesity

BACKGROUND: Pharmacological treatment options for adolescents with obesity are very limited. Glucagon-like-peptide-1 (GLP-1) receptor agonist could be a treatment option for adolescent obesity. OBJECTIVE: To investigate the effect of exenatide extended release on body mass index (BMI)-SDS as primary outcome, and glucose metabolism, cardiometabolic risk factors, liver steatosis, and other BMI metrics as secondary outcomes, and its safety and tolerability in adolescents with obesity. METHODS: Six-month, randomized, double-blinded, parallel, placebo-controlled clinical trial in patients (n = 44, 10-18 years, females n = 22) with BMI-SDS &gt; 2.0 or age-adapted-BMI &gt; 30 kg/m2 according to WHO were included. Patients received lifestyle intervention and were randomized to exenatide extended release 2 mg (n = 22) or placebo (n = 22) subcutaneous injections given once weekly. Oral glucose tolerance tests (OGTT) were conducted at the beginning and end of the intervention. RESULTS: Exenatide reduced (P &lt; .05) BMI-SDS (-0.09; -0.18, 0.00), % BMI 95th percentile (-2.9%; -5.4, -0.3), weight (-3 kg; -5.8, -0.1), waist circumference (-3.2 cm; -5.8, -0.7), subcutaneous adipose tissue (-552 cm3 ; -989, -114), 2-hour-glucose during OGTT (-15.3 mg/dL; -27.5, -3.1), total cholesterol (11.6 mg/dL; -21.7, -1.5), and BMI (-0.83 kg/m2 ; -1.68, 0.01) without significant change in liver fat content (-1.36; -3.12, 0.4; P = .06) in comparison to placebo. Safety and tolerability profiles were comparable to placebo with the exception of mild adverse events being more frequent in exenatide-treated patients. CONCLUSIONS: Treatment of adolescents with severe obesity with extended-release exenatide is generally well tolerated and leads to a modest reduction in BMI metrics and improvement in glucose tolerance and cholesterol. The study indicates that the treatment provides additional beneficial effects beyond BMI reduction for the patient group.De två första författarna delar förstaförfattarskapet</p

Steam locomotive K107, holiday special passenger train arriving at Noojee Station, Noojee, Victoria, April 1935 [picture] /

Part of collection: Buckland collection of railway transport photographs.; Title devised by cataloguer based on inscription and other reference sources.; Inscriptions: "K 107 Noojee 4/35"--In blue ink on verso; "Photograph by John Buckland"--Stamp on verso.; Condition: Good.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4196094