11 research outputs found
UV-triggered syndrome of Gougerot-Carteaud - mechanical damage or immunological reaction
Papillomatosis papulosa confluens reticulata et pigmentata is a rare dermatosis that presents clinically with pigmented, papillomatous, hyperkeratotic plaques with central confluence and reticulated peripheral pattern. The etiology remains unclear but current data points to a keratinization defect as the main pathological mechanism. There is one case report in the literature of a UV-induced Papillomatosis papulosa confluens reticulata et pigmentata. We present a 16-year old patient with clinical and histological diagnosis of confluent and reticulated papillomatosis. The characteristic lesions involved sun-exposed areas and developed after intense sun exposure. As an etiologic factor, ultraviolet light may lead to mechanical epidermal damage and further keratinization modification. On the other hand, in the setting of genetically predetermined resistance to UV-immunosuppression mechanisms, the newly formed epidermal antigens could potentially trigger an immune reaction resulting in skin eruption.Scripta Scientifica Medica 2013; 45(4): 88-91
Acute generalized exanthematous pustulosis (AGEP): a literature review
Acute generalized exanthematous pustulosis (AGEP) is a rare drug-induced pustular cutaneous reaction. The clinical course is characteristic with a sudden onset of multiple sterile pustules on an erythematous base with fever and neutrophilia, followed by a spontaneous resolution within two weeks. Drug-specific T cells play the main role in the pathogenesis, but the exact cytokine cascade and genetic background are yet to be elucidated. Timely and exact recognition is important in order to prevent confusion with infections and psoriasis and hence institution of unnecessary and wrong treatments. The diagnosis may be confirmed by typical history, identification of a culprit drug, histopathology and patch testing. The purpose of this review is to present the current knowledge on AGEP and its association with various drugs in the context of a drug allergic reaction.Scripta Scientifica Medica 2013; 45(4): 7-12
Systematized epidermolytic epidermal nevus (ichthyosis hystrix)
Ichthyosis hystrix is a term used to describe an autosomal dominant rare form of an ichthyosiform dermatosis which is characterized by hyperkeratotic spiny scales. We present a healthy 22-year-old man with lesions which clinically and histopathologically corresponded to the rare inherited disorder ichthyosis hystrix
Acquired Ulcero-Mutilating Bilateral Acro-Osteopathy (Bureau-Barrière Syndrome)
We present a 35-year-old male patient with Bureau-Barrière syndrome. Bureau-Barrière syndrome is an ulcero-mutilating acropathy almost invariably associated with excessive alcohol intake. It presents with a triad of trophic skin changes with recurrent ulcerations, bone lesions and nerve damage. The clinical presentation includes chronic painless plantar ulcerations with periulcerous hyperkeratosis, hyperhidrosis, livedoid skin colour, nail dystrophy, widening and infiltration of the toes and common interdigital mycoses. Other non-specific skin changes related to the alcohol consumption are commonly observed as well. The condition affects mainly middle-aged men suffering from alcoholism. Often a bilateral location at the lower limb of male alcoholics has been described, as in our patient. Successful treatment of the Bureau-Barrière syndrome requires an interdisciplinary approach. Cessation of alcohol intake and smoking is of paramount importance
Eosinophilic fasciitis - a diagnosis to consider. case report and review of the literature
Eosinophilic fasciitis is a rare sclerodermatous dis order with controversial etiology and pathogenesis. Constellation of clinical features and laboratory abnormalities establishes the di agnosis: deep induration of the subcutaneous tissue, flexion joint contractures, high eosinophil count in blood and bone marrow, characteristic histologic find ings, arthralgia, myalgia, negative visceral involvement, negative Raynaud phenomenon, history of excessive physical exercise, therapeutic sensitivity to corticosteroids and characteristic MRI findings. The main stay of treatment are systemic corticosteroids and early intervention is usually effective with a benign course of the disease. Refractory cases may require immunosuppressive or alternative agents.Scripta Scientifica Medica 2010;42(1):11-1
Infantile Haemangiomas: Epidemiological Characteristics and Management Approach // Π₯Π΅ΠΌΠ°Π½Π³ΠΈΠΎΠΌΠΈ Π² ΠΊΡΡΠΌΠ°ΡΠ΅ΡΠΊΠ° ΠΈ Π΄Π΅ΡΡΠΊΠ° Π²ΡΠ·ΡΠ°ΡΡ β Π΅ΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΈ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ½ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅
Haemangiomas are the most common benign tumours in children up to the age of 1 year, affecting
approximately 4-5 to 10% of those born in normal gestational age and up to 30% of premature infants.
They are characterized by three well-defined stages of evolution with different clinical characteristics:
rapid proliferative stage, stage of a stable state and slow spontaneous regression. The different morphological characteristics of the lesion in different stages require a treatment approach that is specific to the stage. Haemangiomas usually occur in the first days or weeks after birth and until the 9th year undergo spontaneous resolution in about 90% of patients. Despite their benign nature and expected resolution, in 40-50% of patients, at the site of the haemangioma, remain telangiectasia, discolouration, fibrofatty tissue, atrophic wrinkling of the skin or scarring. In some patients, the haemangiomas in the active phase are associated with functional and/or life-threatening complications.
The revolutionary development of the understanding of the pathological cascade of infantile haemangiomas and the introduction of innovative, highly effective and safe therapy, as well as the lack of data on haemangiomas in the Bulgarian population, motivated the development of a series of studies on the aetiology and therapy of infantile haemangiomas. The results of our studies related to this thesis help clarify the role of risk factors for the development of haemangiomas, establish the efficacy of treatment with topical P-blockers, and determine the impact of infantile haemangiomas on family life.Π₯Π΅ΠΌΠ°Π½Π³ΠΈΠΎΠΌΠΈΡΠ΅ ΡΠ° Π½Π°ΠΉ-ΡΠ΅ΡΡΠΎ ΡΡΠ΅ΡΠ°Π½ΠΈΡΠ΅ Π΄ΠΎΠ±ΡΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½ΠΈ ΡΡΠΌΠΎΡΠΈ ΠΏΡΠΈ Π΄Π΅ΡΠ° Π½Π° Π²ΡΠ·ΡΠ°ΡΡ Π΄ΠΎ 1 Π³ΠΎΠ΄ΠΈΠ½Π°,
ΠΊΠ°ΡΠΎ Π·Π°ΡΡΠ³Π°Ρ ΠΏΡΠΈΠ±Π»ΠΈΠ·ΠΈΡΠ΅Π»Π½ΠΎ 4-5 Π΄ΠΎ 10% ΠΎΡ ΡΠΎΠ΄Π΅Π½ΠΈΡΠ΅ Π² Π½ΠΎΡΠΌΠ°Π»Π½Π° Π³Π΅ΡΡΠ°ΡΠΈΠΎΠ½Π½Π° Π²ΡΠ·ΡΠ°ΡΡ ΠΈ Π΄ΠΎ 30% ΠΎΡ
Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½ΠΈΡΠ΅ ΠΊΡΡΠΌΠ°ΡΠ΅ΡΠ°. Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΈΡΠ°Ρ ΡΠ΅ Ρ ΡΡΠΈ Π΄ΠΎΠ±ΡΠ΅ ΠΎΡΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈ ΡΠ°Π·ΠΈ Π½Π° ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΠΈ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ½ΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ: Π±ΡΡΠ·Π° ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½Π° ΡΠ°Π·Π°, ΡΠ°Π·Π° Π½Π° ΡΡΠ°Π±ΠΈΠ»Π½ΠΎ ΡΡΡΡΠΎΡΠ½ΠΈΠ΅ ΠΈ Π±Π°Π²Π½Π°
ΡΠΏΠΎΠ½ΡΠ°Π½Π½Π° ΡΠ΅Π³ΡΠ΅ΡΠΈΡ. Π Π°Π·Π»ΠΈΡΠ½ΠΈΡΠ΅ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ Π½Π° Π»Π΅Π·ΠΈΡΡΠ° Π² ΡΠ°Π·Π»ΠΈΡΠ½ΠΈΡΠ΅ ΡΡΠ°Π΄ΠΈΠΈ
Π½Π°Π»Π°Π³Π°Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅Π½ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ Π½Π° Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΏΡΡΠΌΠΎ ΡΠ°Π·Π°ΡΠ°. Π₯Π΅ΠΌΠ°Π½Π³ΠΈΠΎΠΌΠΈΡΠ΅ ΠΎΠ±ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΎ ΡΠ΅ ΠΏΠΎΡΠ²ΡΠ²Π°Ρ Π²
ΠΏΡΡΠ²ΠΈΡΠ΅ Π΄Π½ΠΈ ΠΈΠ»ΠΈ ΡΠ΅Π΄ΠΌΠΈΡΠΈ ΡΠ»Π΅Π΄ ΡΠ°ΠΆΠ΄Π°Π½Π΅ΡΠΎ ΠΈ Π΄ΠΎ 9-ΡΠ°ΡΠ° Π³ΠΎΠ΄ΠΈΠ½Π° ΠΏΡΠ΅ΡΡΡΠΏΡΠ²Π°Ρ ΠΎΠ±ΡΠ°ΡΠ½ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΏΡΠΈ
ΠΎΠΊΠΎΠ»ΠΎ 90% ΠΎΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈΡΠ΅. ΠΡΠΏΡΠ΅ΠΊΠΈ Π΄ΠΎΠ±ΡΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½ΠΈΡ ΡΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΈ ΠΎΡΠ°ΠΊΠ²Π°Π½ΠΎΡΠΎ ΠΎΠ±ΡΠ°ΡΠ½ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅,
ΠΏΡΠΈ 40-50% ΠΎΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈΡΠ΅ Π½Π° ΠΌΡΡΡΠΎΡΠΎ Π½Π° Ρ
Π΅ΠΌΠ°Π½Π³ΠΈΠΎΠΌΠ° ΠΎΡΡΠ°Π²Π°Ρ ΡΠ΅Π»Π°Π½Π³ΠΈΠ΅ΠΊΡΠ°Π·ΠΈΠΈ, ΠΏΡΠΎΠΌΡΠ½Π° Π² ΡΠ²Π΅ΡΠ°,
ΡΠΈΠ±ΡΠΎΠ·Π½ΠΎ-ΠΌΠ°ΡΡΠ½Π° ΡΡΠΊΠ°Π½, Π°ΡΡΠΎΡΠΈΡΠ½ΠΎ Π½Π°Π±ΡΡΡΠΊΠ²Π°Π½Π΅ Π½Π° ΠΊΠΎΠΆΠ°ΡΠ° ΠΈΠ»ΠΈ ΡΠΈΠΊΠ°ΡΡΠΈΠΊΡΠΈ, Π° ΠΏΡΠΈ ΡΠ°ΡΡ ΠΎΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈΡΠ΅ Ρ
Π΅ΠΌΠ°Π½Π³ΠΈΠΎΠΌΠΈΡΠ΅ Π² Π°ΠΊΡΠΈΠ²Π½Π°ΡΠ° ΡΠ°Π·Π° ΡΠ° ΡΠ²ΡΡΠ·Π°Π½ΠΈ Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»Π½ΠΈ ΠΈ/ΠΈΠ»ΠΈ
ΠΆΠΈΠ²ΠΎΡΠΎΠ·Π°ΡΡΡΠ°ΡΠ°Π²Π°ΡΠΈ ΡΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡ.
Π Π΅Π²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΡΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π½Π° ΡΠ°Π·Π±ΠΈΡΠ°Π½Π΅ΡΠΎ Π½Π° ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½Π°ΡΠ° ΠΊΠ°ΡΠΊΠ°Π΄Π° Π½Π° Π΄Π΅ΡΡΠΊΠΈΡΠ΅ Ρ
Π΅ΠΌΠ°Π½Π³ΠΈΠΎΠΌΠΈ ΠΈ
Π²ΡΠ²Π΅ΠΆΠ΄Π°Π½Π΅ΡΠΎ Π½Π° ΠΈΠ½ΠΎΠ²Π°ΡΠΈΠ²Π½Π° Π²ΠΈΡΠΎΠΊΠΎ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½Π° ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½Π° ΡΠ΅ΡΠ°ΠΏΠΈΡ, ΠΊΠ°ΠΊΡΠΎ ΠΈ Π»ΠΈΠΏΡΠ°ΡΠ° Π½Π° Π΄Π°Π½Π½ΠΈ Π·Π°
Ρ
Π΅ΠΌΠ°Π½Π³ΠΈΠΎΠΌΠΈΡΠ΅ Π² Π±ΡΠ»Π³Π°ΡΡΠΊΠ°ΡΠ° ΠΏΠΎΠΏΡΠ»Π°ΡΠΈΡ, ΠΌΠΎΡΠΈΠ²ΠΈΡΠ°Ρ
Π° ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ²Π°Π½Π΅ΡΠΎ Π½Π° ΡΠ΅ΡΠΈΡ ΠΎΡ ΠΏΡΠΎΡΡΠ²Π°Π½ΠΈΡ Π·Π°
Π΅ΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΡΠ° ΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΡΡΠ° Π½Π° Ρ
Π΅ΠΌΠ°Π½Π³ΠΈΠΎΠΌΠΈΡΠ΅ Π² ΠΊΡΡΠΌΠ°ΡΠ΅ΡΠΊΠ° ΠΈ Π΄Π΅ΡΡΠΊΠ° Π²ΡΠ·ΡΠ°ΡΡ. Π Π΅Π·ΡΠ»ΡΠ°ΡΠΈΡΠ΅ ΠΎΡ Π½Π°ΡΠΈΡΠ΅
ΠΏΡΠΎΡΡΠ²Π°Π½ΠΈΡ, ΠΎΠ±Π΅ΠΊΡ Π½Π° ΡΠΎΠ·ΠΈ Π΄ΠΈΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π΅Π½ ΡΡΡΠ΄, ΡΠΏΠΎΠΌΠ°Π³Π°Ρ Π·Π° ΠΈΠ·ΡΡΠ½ΡΠ²Π°Π½Π΅ Π½Π° ΡΠΎΠ»ΡΡΠ° Π½Π° ΡΠΈΡΠΊΠΎΠ²ΠΈΡΠ΅
ΡΠ°ΠΊΡΠΎΡΠΈ Π·Π° ΡΠ°Π·Π½ΠΈΡΠ΅ Π½Π° Ρ
Π΅ΠΌΠ°Π½Π³ΠΈΠΎΠΌΠΈ, Π·Π° ΡΡΡΠ°Π½ΠΎΠ²ΡΠ²Π°Π½Π΅ Π½Π° Π΅ΡΠ΅ΠΊΡΠ° ΠΎΡ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Ρ Π»ΠΎΠΊΠ°Π»Π½ΠΈ Π -Π±Π»ΠΎΠΊΠ΅ΡΠΈ ΠΈ Π·Π°
ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ½Π΅ Π½Π° Π΅ΡΠ΅ΠΊΡΠ°, ΠΊΠΎΠΉΡΠΎ Π΄Π΅ΡΡΠΊΠΈΡΠ΅ Ρ
Π΅ΠΌΠ°Π½Π³ΠΈΠΎΠΌΠΈ ΠΎΠΊΠ°Π·Π²Π°Ρ Π²ΡΡΡ
Ρ ΠΆΠΈΠ²ΠΎΡΠ° Π½Π° ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²ΠΎΡΠΎ
Aquagenic keratoderma. Two new case reports and a new hypothesis
Aquagenic keratoderma has been described as a transient condition affecting predominantly young females and defined clinically by the appearance of palmar hyper-wrinkling accentuated after immersion in water. We present two new cases with aquagenic palmoplantar acrokeratoderma - a child and a young male. A significant clinical improvement was achieved after topical treatment with aluminum salts. Aquagenic palmar keratoderma may be a clue to cystic fibrosis in adolescents and young adults. We developed a new hypothesis on its pathogenesis