Skulderplager blant mannlige elitehåndballspillere: Er det en sammenheng mellom skulderplager og skulderbevegelighet og muskelstyrke?

I likhet med andre kastutøvere utsetter håndballspillere skulderleddet for en stor belastning. Epidemiologiske studier har indikert en høy forekomst av skulderplager i sporten, men det foreligger ingen studier som belyser prevalensen av skulderplager hos mannlige utøvere, og lite forskning er gjort for å kartlegge potensielle risikofaktorer. Formålet med denne oppgaven er å redegjøre for prevalensen av skuldersmerter hos mannlige håndballspillere i den norske toppserien, å avdekke skulderbevegelighet og muskelstyrke hos skulderfriske utøvere, samt å belyse en mulig sammenheng mellom skulderplager og skulderbevegelighet og muskelstyrke

Neoantigen-reactive CD8+ T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma

BACKGROUND. Neoantigen-driven recognition and T cell–mediated killing contribute to tumor clearance following adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs). Yet how diversity, frequency, and persistence of expanded neoepitope-specific CD8+ T cells derived from TIL infusion products affect patient outcome is not fully determined. METHODS. Using barcoded pMHC multimers, we provide a comprehensive mapping of CD8+ T cells recognizing neoepitopes in TIL infusion products and blood samples from 26 metastatic melanoma patients who received ACT. RESULTS. We identified 106 neoepitopes within TIL infusion products corresponding to 1.8% of all predicted neoepitopes. We observed neoepitope-specific recognition to be virtually devoid in TIL infusion products given to patients with progressive disease outcome. Moreover, we found that the frequency of neoepitope-specific CD8+ T cells in TIL infusion products correlated with increased survival and that neoepitope-specific CD8+ T cells shared with the infusion product in posttreatment blood samples were unique to responders of TIL-ACT. Finally, we found that a transcriptional signature for lymphocyte activity within the tumor microenvironment was associated with a higher frequency of neoepitope-specific CD8+ T cells in the infusion product. CONCLUSIONS. These data support previous case studies of neoepitope-specific CD8+ T cells in melanoma and indicate that successful TIL-ACT is associated with an expansion of neoepitope-specific CD8+ T cells. FUNDING. NEYE Foundation; European Research Council; Lundbeck Foundation Fellowship; Carlsberg Foundation