Well Built in Albuquerque: The Architecture of the Healthseeker Era, 1900-1940

This thesis examines the architectural and cultural landscape of tuberculosis in Albuquerque during the first decades of the twentieth century. Inspired by a general belief in the healing powers of high-altitude desert air and sunshine, Albuquerque fashioned itself into a popular health resort for consumptives. In \u27Well Built in Albuquerque: The Architecture of the Healthseeker Era, 1900-1940,\u27 I argue that the disease inspired a new and distinctive health landscape in the city that included sanatoriums, boarding houses, and rustic campsites. The architecture, design, and spatial patterning of this landscape reflected prevailing medical and social ideologies concerning both the disease and its cure. Chief among them were a fanatical confidence in the curative properties of climate, a growing national concern with contagion, health discrimination based on social class and stage of disease, and a later dedication to medical science over nature. This study adds to the small body of existing literature on the architecture and landscape of American sanatoriums, and contributes new insights to the historical record of New Mexico and Albuquerque

Leadership Development of Women in Panhellenic Organizations

This study seeks to understand how women of Panhellenic sororities at the University of San Diego (USD) define and perform their meaning of leadership to create positive change in their organizations. My overarching research question was: How can I assist the members of Panhellenic sororities at USD to take up their authority as leaders to influence positive change in their chapter? This research reflects my experiences with Panhellenic sorority women at USD and intentional stakeholders throughout the 2019-2020 academic year. This study was influenced by Ira Chaleff\u27s work on courageous followership, Baxter Magolda’s theory of self-authorship, and David Cooperrider, Diana Whitney, and Jacqueline M. Stavros tenants of appreciative inquiry. A multilayer approach was taken by hosting focus groups, as well as surveying and interviewing multiple stakeholders connected to the Panhellenic sororities at USD including sorority leaders, chapter members, chapter advisors, and inter/national headquarter staff members. The findings reveal actions and strategies for all stakeholders to including campus-based fraternity and sorority life advisors on how to intentionally support the leadership development of Panhellenic sorority women to create positive and sustainable organizational change. Ultimately, by allowing Panhellenic sorority women to make meaning of their influence, as well as claiming their own authority of their membership experience and chapter culture, they are able to create positive change

Apex predator behaviour in a changing Salish Sea: determining the role bald eagle foraging behaviour plays in nutrient cycling and terrestrial food webs under diminishing salmon populations

The semelparous salmonid species are the ecological foundation of Pacific Northwest coastal ecosystems, which span across the international border to encompass the Salish Sea. The annual return of salmonids to their natal streams and decomposition of their carcasses deposits marine-derived nutrients into freshwater ecosystems, which are integral to food web dynamics, nutrient cycling and habitat quality. Bald eagles (Haliaeetus leucocephalus) are apex predators that congregate along riverbanks to scavenge accumulated carcasses, which results in individuals using piracy to steal food items from others. Winners fly to nearby trees to consume carcasses, which are dropped to the forest floor and decomposed by terrestrial invertebrates. While this transfer of nutrients is critical to terrestrial habitat quality, the current decline in salmon populations in the Salish Sea could alter this cycle. Thus, the aim of our study is to determine if a decrease in carcass abundance will alter the piracy rates among eagles and the amount of marine-derived nutrients that are transferred into forests. To accomplish this, field observations on piracy rates will be compared to a simulated crash in salmon populations in an Individual-Based Model to determine how eagles alter their behaviour under decreased carcass abundance. The results will be compared to an isotope analysis of terrestrial invertebrates from perch tree locations. Predicted results include: a) the piracy rate in the IBM will be higher when fewer carcasses are available, b) less nutrients will be transferred to terrestrial ecosystems under low carcass abundance and high competition and c) the N and C isotopic signatures in terrestrial invertebrates under perch trees will be higher than controls. The results of this study will be used in collaboration with other fields to take an ecosystem-based approach to ensure coastal food web dynamics, nutrient cycling and habitat quality are priorities in our transboundary salmon management strategies

To bind or not to bind: Characterization of binding interactions between X29 and U8snoRNA [abstract]

Abstract only availableFaculty Mentor: Brenda Peculis, BiochemistryU8-snoRNP is involved in the processing of the 5.8S and the 28S rRNA, both of which are needed for the formation of the large ribosomal subunit (Peculis and Steitz, 1991). A nucleolar protein, dubbed X29, has the ability to bind and decap U8snoRNA, giving it the capacity to degrade U8RNA (Tomasevic and Peculis, 1999; Ghosh et al, 2004). Initially found in Xenopus, X29 is evolutionarily conserved in vertebrates from humans to sea squirts (MT, unpublished). The x-ray crystallography structure of X29 shows the protein can exist in the form of a homodimer (Scarsdale et al, 2006). The goal of this project was to determine whether the homodimer form or the monomeric version of X29 binds U8RNA and is catalytically active, as well as identify the protein:protein and protein:RNA contacts. I used chemical crosslinkers and identified a 60kD putative crosslink in X29, and formation of a 60kD band was also identified with the human homologue, H29K, but this forms with a lower efficiency. 4-thio-U mediated RNA (UV) crosslinking was used to identify the binding sites for X29 on U8RNA. All crosslinking assays were performed with mutant or truncated RNAs and proteins to more precisely map sites of interaction. The data from X29 were compared to that of H29K to determine whether the protein's activities were conserved among or differed between species. The results of these experiments showed that X29 and H29K both show abilities to form dimers and crosslink to U8 though to differing efficiencies. The U8 mutants have identified putative interaction sites between U8RNA and the proteins, which we are in the process of mapping more precisely

Managing systemic risk in emergency management, organizational resilience and climate change adaptation: a science-policy roadmap

In urban systems, major risks need to be managed by bringing together emergency management, organisational resilience and climate change adaptation. In this endeavour, policy making must make use of disaster science. This chapter applies the theory of cascading, interconnected and compound risk to the practice of preparing for, managing and responding to threats and hazards. This methodology is illustrated with an example from the United Kingdom, namely the work of the Greater London Authority and its partner organisations. London has long been a champion of resilience strategies for dealing with systemic risk. The chapter investigates the potential and limitations of this approach. There remains a need to identify common points of failure, especially where they relate to interconnected domains and where they are driven by climate change. Radical new thinking is required in order to ensure operational continuity in the face of growing systemic risk

Experimental Behavior of High Strength Concrete Slabs Subjected to Shock Loading

Title from PDF of title page, viewed March 23, 2016Thesis advisor: Ganesh ThiagarajanVitaIncludes bibliographical references (page 79-82)Thesis (M.S.)--School of Computing and Engineering. University of Missouri--Kansas City, 2015The design to resist blast loading is required in many private and governmental buildings. The research presented in this thesis characterizes the response of high strength concrete panels, reinforced with high strength vanadium steel, subjected to blast loading under controlled conditions. This work is intended to provide valuable data to study numerical models such as the commonly used single-degree-of-freedom (SDOF) models. The experimental procedure used and data collected from high-strength reinforced concrete (RC) slabs, having two different high-strength reinforcement ratios subjected to shockwave loadings using a blast load simulator are presented in this thesis. The pressure, impulse, and deflection time histories generated from the experiments along with the predicted panel deflection and damage responses are presented. The pressure impulse (PI) curves developed using a SDOF model are compared with the experimental data. Damage assessment generated from the blast load simulator experiments and a comparison of experimental behavior of high strength RC slabs with regular strength RC slabs, having two different Grade 60 regular-strength reinforcement ratios, are also presented. These results showed that while the regular strength slabs with regular strength reinforcing steel experienced slightly higher experimental deflections that the high strength slabs with high strength reinforcing steel, the reinforcement spacing or reinforcement ratio, played a more significant role in both experimental and numerical maximum peak deflections for both the regular strength concrete slabs reinforced with regular strength steel and the high strength concrete slabs reinforced with high strength steel. Experimental quantification of the dynamic resistance curves showed that the slabs with smaller longitudinal reinforcement spacing had greater ductility and post-yield behavior. Furthermore, a parametric study was performed, using the same SDOF model, comparing various high-strength concrete slab thicknesses with varying highstrength reinforcement ratios for maximum numerical deflection. The results from this study showed that the thicker slabs with larger reinforcement ratios yielded smaller maximum numerical deflections than those of the thinner slabs with smaller reinforcement ratios. Finally, the concrete damage patterns of the panels are shown and described.Introduction -- Literature review -- Research significance -- Experimental investigation -- Data results -- Additional SDOF model maximum deflection study -- Parametric study -- Comparison of high strength concrete slabs with regular strength concrete slabs -- Conclusion

SB 106 Congressional and state legislative districts; standards and criteria

This report examines Senate Bill (SB) 106, introduced during the 2018 Virginia General Assembly session to address the criterion of redistricting and the specific impact on racial and ethnic minorities. This legislation is a direct response to previous legislative attempts to address gerrymandering and remains an evolving issue in the Commonwealth

Managing systemic risk in emergency management, organizational resilience and climate change adaptation

Purpose This paper applies the theory of cascading, interconnected and compound risk to the practice of preparing for, managing, and responding to threats and hazards. Our goal is to propose a consistent approach for managing major risk in urban systems by bringing together emergency management, organisational resilience, and climate change adaptation. Design/methodology/approach We develop a theory-building process using an example from the work of the Greater London Authority in the United Kingdom. First, we explore how emergency management approaches systemic risk, including examples from of exercises, contingency plans and responses to complex incidents. Secondly, we analyse how systemic risk is integrated into strategies and practices of climate change adaptation. Thirdly, we consider organisational resilience as a cross cutting element between the approaches. Findings London has long been a champion of resilience strategies for dealing with systemic risk. However, this paper highlights a potential for integrating better the understanding of common points of failure in society and organisations, especially where they relate to interconnected domains and where they are driven by climate change. Originality/value The paper suggests shifting toward the concept of operational continuity to address systemic risk and gaps between Emergency Management, Organizational Resilience and Climate Change Adaptation

The Roles of Occupational Therapy, Physical Therapy, and Speech/Language Pathology in Primary Care

Occupational therapy, physical therapy, and speech language pathology services may be of significant help to patients of nurse practitioners (NPs) in primary care. NPs should be aware of the depth and breadth of services offered by these colleagues, and consider early referral to them. This article describes the different rehabilitation disciplines and some of the ways in which their services may benefit patients. http://www.sciencedirect.com/science/article/pii/S155541550900500

CONTROLLING INFLAMMATION WITH DEXAMETHASONE AFTER ANTERIOR CRUCIATE LIGAMENT INJURY

INTRODUCTION Anterior Cruciate Ligament (ACL) injuries are increasingly common, with about 250 000 ACL ruptures occurring per year in the US [1]. The current treatment for ACL rupture is ACL reconstructive surgery (ACL-R), which aims to successfully restore the biomechanical function of the knee. However, individuals who suffer from ACL injuries, including those who undergo ACL reconstruction, have a 50% chance of developing osteoarthritis (OA) within 10-20 years [2]. Inflammation of the knee joint has been hypothesized to be a factor [3]. Dexamethasone (DEX) is a type of corticosteroid used to control inflammation [4]. The purpose of this study was to determine if DEX treatment following anterior cruciate ligament reconstruction was an effective mechanism of long-term joint protection against the progression of osteoarthritis. METHODS Six female Suffolk cross sheep were allocated into one of three groups: sham surgery, idealized ACL-R surgery, and control. Surgeries were previously accomplished by arthrotomy to the right stifle joint. Animals that underwent idealized ACL reconstructive surgery received a single injection of DEX at the time of the surgery. At 2 weeks post surgery animals were sacrificed and cartilage samples were harvested from both standard as well as visibly damaged locations on the patella (PAT), femoral groove (FG), lateral femoral condyle (LFC), medial femoral condyle (MFC), lateral tibial condyle (LTC), and medial tibial condyle (MTC). These samples were then blinded and graded by three experienced observers on the modified Mankin scale. This scale gives a grade out of 24 based on four categories: safranin-O staining, structure, cell density, and cluster formation. ANOVA with Bonferroni post-hoc analysis was used to determine differences in histological scores between groups, using SPSS 19.0.   RESULTS The average histological grades (and standard deviations) for the PAT, FG, LTP, MTP, LFC, and MFC are displayed in Figure 1. No significant differences were observed between the sham (n=2), ACL-R + DEX (n=2), and control groups in all locations. DISCUSSION AND CONCLUSIONS The similarity between the ACL-R+DEX and control groups indicates that DEX treatment has the potential to have a protective effect against the progression of OA, however further studies must be conducted to ensure long-term efficacy. Increasing the sample size as well as looking at longer time points is recommended to better understand the effect of dexamethasone on the progression of osteoarthriti