17 research outputs found
Spontaneous empyema necessitatis caused by Aspergillus fumigatus in an immunocompetent patient
Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species
Effect of a Quality Improvement Intervention on Clinical Outcomes in Patients in India With Acute Myocardial Infarction: The ACS QUIK Randomized Clinical Trial.
Importance: Wide heterogeneity exists in acute myocardial infarction treatment and outcomes in India. Objective: To evaluate the effect of a locally adapted quality improvement tool kit on clinical outcomes and process measures in Kerala, a southern Indian state. Design, Setting, and Participants: Cluster randomized, stepped-wedge clinical trial conducted between November 10, 2014, and November 9, 2016, in 63 hospitals in Kerala, India, with a last date of follow-up of December 31, 2016. During 5 predefined steps over the study period, hospitals were randomly selected to move in a 1-way crossover from the control group to the intervention group. Consecutively presenting patients with acute myocardial infarction were offered participation. Interventions: Hospitals provided either usual care (control group; n = 10 066 participants [step 0: n = 2915; step 1: n = 2649; step 2: n = 2251; step 3: n = 1422; step 4; n = 829; step 5: n = 0]) or care using a quality improvement tool kit (intervention group; n = 11 308 participants [step 0: n = 0; step 1: n = 662; step 2: n = 1265; step 3: n = 2432; step 4: n = 3214; step 5: n = 3735]) that consisted of audit and feedback, checklists, patient education materials, and linkage to emergency cardiovascular care and quality improvement training. Main Outcomes and Measures: The primary outcome was the composite of all-cause death, reinfarction, stroke, or major bleeding using standardized definitions at 30 days. Secondary outcomes included the primary outcome's individual components, 30-day cardiovascular death, medication use, and tobacco cessation counseling. Mixed-effects logistic regression models were used to account for clustering and temporal trends. Results: Among 21 374 eligible randomized participants (mean age, 60.6 [SD, 12.0] years; n = 16 183 men [76%] ; n = 13 689 [64%] with ST-segment elevation myocardial infarction), 21 079 (99%) completed the trial. The primary composite outcome was observed in 5.3% of the intervention participants and 6.4% of the control participants. The observed difference in 30-day major adverse cardiovascular event rates between the groups was not statistically significant after adjustment (adjusted risk difference, -0.09% [95% CI, -1.32% to 1.14%]; adjusted odds ratio, 0.98 [95% CI, 0.80-1.21]). The intervention group had a higher rate of medication use including reperfusion but no effect on tobacco cessation counseling. There were no unexpected adverse events reported. Conclusions and Relevance: Among patients with acute myocardial infarction in Kerala, India, use of a quality improvement intervention compared with usual care did not decrease a composite of 30-day major adverse cardiovascular events. Further research is needed to understand the lack of efficacy. Trial Registration: clinicaltrials.gov Identifier: NCT02256657
Levamisole-induced leukocytoclastic vasculitis and neutropenia in a patient with cocaine use: An extensive case with necrosis of skin, soft tissue, and cartilage
EUF-analysis of tea soils of Southern India and tea productivity
The relationship between EUF extractable nutrients and conventional soil test extractable nutrients in the acid soils of Southern India on one hand and that between EUF values and tea productivity on the other are described. Close correlation exists between EUF-NO3–N at 20°C and CuSO4–Ag2SO4-extractable NO3–N (r=0.98***), EUF-Norg and Morgan's reagent extractable NH4–N (r=0.97***), total EUF-N and CuSO4–Ag2SO4-extractable NO3–N plus Morgan's reagent NH4–N (r=0.96***), EUF-P at 20°C and modified Bray II-P (r=0.93***) and EUF-P at 20°C plus that at 80°C and modified Bray II-P (r=0.91***). The EUF-K at 20°C shows close correlation with NH4OAc–K (r=0.80***), Ag-thiourea-K (r=0.86***) and Morgan's reagent-K (r=0.84***) whereas the EUF-K at 80°C shows close correlation with the difference in K contents of NH4OAc–K and Ag-thiourea-K (r=0.92***) or of NH4OAc–K and Morgan's reagent-K (r=0.93***) and fixed NH4–N (r=0.89***). EUF-Ca, EUF-Mg and EUF-Mn do not show any relationship with conventional soil test values. Tea productivity is strongly associated with EUF-N and EUF-P extracted at 20°C
Formulation Design of Self-Microemulsifying Drug Delivery Systems for Improved Oral Bioavailability of Celecoxib
Celecoxib is a hydrophobic and highly permeable drug belonging to class II of biopharmaceutics classification
system. Low aqueous solubility of celecoxib leads to high variability in absorption after oral administration.
Cohesiveness, low bulk density and compressibility, and poor flow properties of celecoxib impart complications
in it’s processing into solid dosage forms. To improve the solubility and bioavailability and to get faster onset of
action of celecoxib, the self-microemulsifying drug delivery system (SMEDDS) was developed. Composition of
SMEDDS was optimized using simplex lattice mixture design. Dissolution efficiency, t85%, absorbance of diluted
SMEDDS formulation and solubility of celecoxib in diluted formulation were chosen as response variables. The
SMEDDS formulation optimized via mixture design consisted of 49.5% PEG-8 caprylic/capric glycerides, 40.5%
mixture of Tween20 and Propylene glycol monocaprylic ester (3 : 1) and 10% celecoxib, which showed signifi-
cantly higher rate and extent of absorption than conventional capsule. The relative bioavailability of the
SMEDDS formulation to the conventional capsule was 132%. The present study demonstrated the suitability of
mixture design to optimize the compositions for SMEDDS. The developed SMEDDS formulations have the potential
to minimize the variability in absorption and to provide rapid onset of action of celecoxib