18 research outputs found
Securing Internet Protocol (IP) Storage: A Case Study
Storage networking technology has enjoyed strong growth in recent years, but
security concerns and threats facing networked data have grown equally fast.
Today, there are many potential threats that are targeted at storage networks,
including data modification, destruction and theft, DoS attacks, malware,
hardware theft and unauthorized access, among others. In order for a Storage
Area Network (SAN) to be secure, each of these threats must be individually
addressed. In this paper, we present a comparative study by implementing
different security methods in IP Storage network.Comment: 10 Pages, IJNGN Journa
Doped Helium Nanodroplets in Intense Few-cycle Infrared Pulses
Die vorliegende Arbeit beschreibt experimentelle Untersuchungen zur Wechselwirkung ultrakurzer (10 fs, 800 nm) Laserpulse mit Helium-Nanotröpfchen. In Einpulsmessungen konnte bei Spitzenintensitäten im Bereich von 10^14 bis 10^15 W/cm^2 gezeigt werden, dass weniger als 10 Dotierungsatome in einem aus 10000 Heliumatomen bestehenden Tröpchen um eine vollständige Ionisierung zu “zünden” ausreichen. Diese experimentellen Beobachtungen, die durch theoretische Modellrechnungen gestützt werden, zeigen erstmalig die sehr effiziente Absorption und resonante Kopplung intensiver Laserfelder im nahen Infraroten an Cluster-Nanoplasmen auf einer Zeitskala von 10 fs. Anhand von Pump-Probe Messungen, die mit zwei zeitlich verzögerten Laserpulsen durchgeführt wurden, konnte die Auswirkung der Dotierung auf die bei der Ausdehnung des teilweise ionisierten Clusters auftretende Nanoplasma- Resonanz untersucht werden. Die Rolle der sich im Zentrum des Clusters befindlichen hochgeladenen Dotierungsatome (typischerweise Xenon) und der sie umgebenden Schale aus Helium-Ionen auf die auf (Sub-) Pikosekunden-Zeitskalen stattfindende Clusterexpansion wurde untersucht. Hierbei wurde erstmalig die Wichtigkeit der sich schnell ausdehnenden Helium-Schalen experimentell erkannt, wodurch die vorliegende Arbeit den Anstoß zu einer neuen Betrachtungsweise der expansionsinduzierten Resonanz in dotierten Nanotröpfchen liefert
Multilayer nanoparticle arrays for broad spectrum absorption enhancement in thin film solar cells
In this paper, we present a theoretical study on the absorption efficiency
enhancement of a thin film amorphous Silicon (a-Si) photovoltaic cell over a
broad spectrum of wavelengths using multiple nanoparticle arrays. The light
absorption efficiency is enhanced in the lower wavelengths by a nanoparticle
array on the surface and in the higher wavelengths by another nanoparticle
array embedded in the active region. The efficiency at intermediate wavelengths
is enhanced by the simultaneous resonance from both nanoparticle layers. We
optimize this design by tuning the radius of particles in both arrays, the
period of the array and the distance between the two arrays. The optimization
results in a total quantum efficiency of 62.35% for a 300nm thick a-Si
substrate.Comment: - Article Published in Optics Express on 7 Apr 2014. Link:
http://www.opticsinfobase.org/oe/abstract.cfm?uri=oe-22-103-A80
Transdermal Delivery of Febuxostat Using Elastic Liposomes – Formulation and Characterisation
The main objective of this work was to formulate and evaluate the febuxostat
loaded elastic liposomes. Elastic liposomes increases transdermal efficiency of drug and
reduces the drawbacks of febuxostat, it improves bioavailability of drug and avoids
enzymatic degradation in stomach., ELs formulation target the site of action by
administering via transdermal route and also with effect of edge activator it improves the
entrapment efficiency of drug.
Elastic liposomes were prepared by thin film hydration technique using rotary
flask evaporator. it was formulated by using soyabean lecithin (phospholipids), edge
activators such as tween 80, span 80 and GMO. Concentration of lipid and surfactant set as
an dependent variable. based on independent variable values optimised formulation was
selected.
These elastic liposomes were obtained by varying surfactant concentration from
5%-20% and phospholipid concentration based on this by varying its concentration about 12
formulations were prepared. From the evaluation of formulation concentration level was
optimised.
The prepared ELs of F1 to F12 formulation were evaluated for its physical and
chemical characteristics such as particle size, surface morphology, entrapment efficiency,
zeta potential .the evaluated batches shows good physio chemical characteristics especially
F3 and F6 formulation shows good zeta potential range(-33.2,-46.2) and particle size
range(217.3nm,165.5) compared to that of other formulation.
On the basis of these result this selected formulation were chosen for In-vitro
dissolution studies .this study was carried out by using dialysis membrane diffusion method
by using phosphate buffer pH -7.4.the release of drug from F3 formulation has better
sustainable effect compared to that of F6 formulation.so this chosen as an optimised elastic
liposomal formulation and release kinetic studies were done for this formulation.
From the results of release studies the data’s was fitted into kinetic release models
and found out that the release mechanism follows higuchi kinetic model that indicates that the
mechanism of release is diffusion.
CHAPTER 08 SUMMARY AND CONCLUSION
DEPARTMENT OF PHARMACEUTICS,COLLEGE OF PHARMACY,MMC,MADURAI Page 100
From these results of this formulation optimised formulation has been selected for
formulating a gel.
The stability of ELs formulation was evaluated after stored at room temperature
and refrigeration temperature for 30 days. Entrapment efficiency and drug content were
calculated at different time intervals. Refrigerated formulation shows better stability compare
to that of formulation stored at room temperature.
The optimised F3 formulation was further formulated as a transdermal gel ,it
improves patient compliance and permeation capacity of drug. elastic liposomes were already
having good permeation ability.by using gel as a carrier it also attenuate its permeability. ELs
hydrogel was formulated using carbopol934 as a polymer with addition of triethanolamine
which neutralise the gel.
The formulated hydro gel was evaluated for physical and chemical characteristics
like morphological characteristics-homogeneity, grittiness, clarity, pH of gel, viscosity and
spreadability of gel .visual inspection of gel seems to be good in nature, it was clear , free
from grittiness. The pH of gel obtained in the range of 6.5-7.4. its an optimum pH for topical
application .Formulated gel had an better spreadability value in lesser time periodand it also
had better viscosity value.
In vitro skin permeation studies was done for F3 Els gel formulation by using
goat skin as an permeation barrier in an open end test tube method ,it shows good
permeability in 12 hours study about 90% of drug was get permeated over the skin
From the result of physiochemical characterisation, In vitro characterisation
studies, skin permeation studies, release kinetic studies.it was found that elastic liposomes
containing febuxostat shows better permeation, it would increases therapeutic efficacy of
drug in the treatment of gout.
CONCLUSION:
Elastic liposomes are especially optimised particles or vesicles which can provide a
novel solution for transdermal delivery. febuxostat loaded elastic liposomes were prepared
and evaluated for different parameters like microscopy, particle size, zeta potential, in-vitro
drug release etc., from the above observation, it can be concluded that sonication is an
essential tool for preparation, and while comparing the EE, elastic liposomes containing
Phosphotidylcholine(PC): Span 80 at a ratio of 85:15(100%) showed the highest value with
respect to all other formulations. The highest sustained action was observed for F3
formulation. The optimised elastic liposomal formulation F3 followed the Higuchi release
over the 24 hours. The optimised F3 formulation was further formulated as topical hydrogel
and evaluated.this result showed that it shows better skin permeation ability
Aerodinamičan dizajn i analiza motorističke kacige s vizirom protiv odsjaja
The number of motorcycle accidents has increased in the last two decades. Helmet can protect the vehicle riders from severe injuries during road accident to certain extent. To design a functional helmet, it is important to analyse the shape of the helmet and visor portion. Therefore, the attempt has been made to design and analyze new helmet by considering the pressure drag and anti-glare visor. The pressure drag resistance presses the helmet against the neck portion of the rider. The shape of an aerodynamic helmet can reduce the drag pressure. The spherical shape and new aerodynamic shape helmets are designed using Pro-E software. Pressure drag is calculated and comparison is made on the basis of drag pressure.Broj motociklističkih nesreća u posljednja se dva desetljeća povećao. Kaciga u određenoj mjeri može zaštititi motocikliste od teških ozljeda koje je moguće zadobiti tijekom prometne nesreće. Prilikom dizajniranja funkcionalne kacige važno je analizirati oblik kacige i veličinu vizira. Iz tog se razloga pokušalo dizajnirati i analizirati novu kacigu uzimajući u obzir tlak otpora zraka i vizir protiv odsjaja. Tlak otpora zraka pritišće kacigu na vratni dio tijela vozača. Oblik aerodinamične kacige može smanjiti pritisak otpora zraka. Kacige sfernog oblika i novog aerodinamičnog oblika izrađene su pomoću Pro-E software-a. Izračunati su tlakovi otpora zraka za oba oblika kacige i napravljena je usporedba rezultata
Filamentation without intensity clamping
We present measurements of the supercontinuum emission (SCE) from ultrashort Ti:Saph laser pulse filamentation in air in a tightly focused geometry. The spectral broadening of SCE indicates that peak intensities exceed the clamping value of a few 1013 W/cm2 obtained for filamentation in a loose focusing geometry by at least one order of magnitude. We provide an interpretation for this regime of filamenation without intensity clamping
A Framework for Prediction and Storage of Battery Life in IoT Devices using DNN and Blockchain
As digitization increases, the need to automate various entities becomes
crucial for development. The data generated by the IoT devices need to be
processed accurately and in a secure manner. The basis for the success of such
a scenario requires blockchain as a means of unalterable data storage to
improve the overall security and trust in the system. By providing trust in an
automated system, with real-time data updates to all stakeholders, an improved
form of implementation takes the stage and can help reduce the stress of
adaptability to complete automated systems. This research focuses on a use case
with respect to the real time Internet of Things (IoT) network which is
deployed at the beach of Chicago Park District. This real time data which is
collected from various sensors is then used to design a predictive model using
Deep Neural Networks for estimating the battery life of IoT sensors that is
deployed at the beach. This proposed model could help the government to plan
for placing orders of replaceable batteries before time so that there can be an
uninterrupted service. Since this data is sensitive and requires to be secured,
the predicted battery life value is stored in blockchain which would be a
tamper-proof record of the data.Comment: Accepted for presentation at IEEE GLOBECOM 202
A Cluster-Based Energy-Efficient Secure Optimal Path-Routing Protocol for Wireless Body-Area Sensor Networks
Recently, research into Wireless Body-Area Sensor Networks (WBASN) or Wireless Body-Area Networks (WBAN) has gained much importance in medical applications, and now plays a significant role in patient monitoring. Among the various operations, routing is still recognized as a resource-intensive activity. As a result, designing an energy-efficient routing system for WBAN is critical. The existing routing algorithms focus more on energy efficiency than security. However, security attacks will lead to more energy consumption, which will reduce overall network performance. To handle the issues of reliability, energy efficiency, and security in WBAN, a new cluster-based secure routing protocol called the Secure Optimal Path-Routing (SOPR) protocol has been proposed in this paper. This proposed algorithm provides security by identifying and avoiding black-hole attacks on one side, and by sending data packets in encrypted form on the other side to strengthen communication security in WBANs. The main advantages of implementing the proposed protocol include improved overall network performance by increasing the packet-delivery ratio and reducing attack-detection overheads, detection time, energy consumption, and delay
Image characterization of certain Sobolev spaces under Schr¨odinger semigroup
This thesis deals with the study of characterizing the image of some function
spaces under Schr¨odinger semigroup. This thesis is divided in to four parts.
In chapter 2 we consider the Schr¨odinger semigroup for Laplacian � on Rn and
characterize the image of Sobolev space on Rn under this semi group as weighted
Bergman space HL2(C; um
t (z)dz) (up to equivalence of norms). Similarly we characterize
the image of Hermite-Sobolev space under Schr¨odinger semigroup associated
to Hermite operator H on Rn.
In chapter 3, we consider the Schr¨odinger semigroup for the Dunkl-Laplacian
��, associated to a finite reflection group G on Rn. We characterize the image of
L2(Rn; eu2h�(u)du) under this semigroup as a reproducing kernel Hilbert space.
For the reflection group Zn
2 , we identify the images of the Dunkl-Sobolev spaces in
L2(Rn; h�(u)du) under the associated Schr¨odinger semigroup eit� as a reproducing
kernel Hilbert space (up to equivalence of norms). Also we establish similar kind
of results for Schr¨odinger semigroup associated to Dunkl-Hermite operator.
Chapter 4 deals with the sampling in the space, HL2(C; um
t (z)dz). We show
that for given a separated sequence Z in C is a sampling for HL2(C; u0
t (z)dz) if and
only if its lower density
Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities
Labeo rohita were exposed to amoxicillin at a concentration of 1 mg/L (Treatment -I) and 0.5 mg/L (Treatment-II) for a period of 35 days. Numerous alterations were found in amoxicillin treatment groups when compared to the control group. Hemoglobin (Hb), hematocrit (Hct), and erythrocytes (RBCs) levels were significantly (P < 0.05) decreased. Leukocytes (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were significantly (P < 0.05) increased. In the plasma and gill tissues, ionic compounds (sodium, potassium, and chloride) levels were significantly declined throughout the treatment period. The plasma biochemical profiles were significantly altered: glucose level remained low (except at the end of 7th day in Treatment -I) till 35 days of the treatment period. Biphasic trend occurred in the protein level, significant increase was observed on 7th and 28th day (Treatment -I and -II), and 35th day (Treatment -I), and in remaining days its level was found to be decreased. Glutamate oxaloacetate transaminase (GOT) activity in the plasma was inhibited significantly, whereas in the gill, liver, and kidney tissues the enzyme activity was elevated. Plasma glutamate pyruvate transaminase (GPT) activity was inhibited throughout the study period. GPT activity in the gill was found to be elevated during the treatment period. Liver GPT activity was elevated in all the treatments except 28th (Treatment-I) and 35th day (Treatment-I, and II). GPT activity in the kidney was elevated (except 14th day in Treatment-II). Lactate dehydrogenase (LDH) activity was inhibited in plasma (except 14th day in Treatment-II), gill, liver (except 7th day in Treatment-I), and kidney tissues significantly (P < 0.05). The present study emphasizes that amoxicillin at 1 and 0.5 mg/L concentrations affects the hematological/biochemical/electrolytes/enzymological parameters of fish and these biomarkers serve as an effective test system for environmental risk assessment of pharmaceuticals in the aquatic environment