A collision aware priority level medium access control protocol for underwater acoustic sensor networks

The Underwater Acoustic Sensor Network (UASN) plays a significant role in many application areas like surveillance, security, commercial and industrial applications. In UASN routing, propagation delay and collision are perennial problems due to data transfers from various sensor nodes to the Sink Node (SN) at the same time. In this paper, we propose a Collision Aware Priority Level mechanism based on Medium Access Control protocol (CAPL-MAC) for transferring data from the Sensor Head (SH) to the SN. In the proposed protocol, we use Parallel Competition Scheme (PCS) for high channel utilization and energy saving of battery. In each Competition Cycle (CC), the data packet produced by each SH in a different time slot can join in CC for data packet transmission in parallel with high channel utilization. In CAPL-MAC, each SH is assigned with a different Priority Level Number (PLN) during every CC. Instead of broadcasting, each SH sends its respective PLN to each SH with the help of the nearest SH to save battery energy. Based on the highest PLN, each SH communicates with SN without collision, and it will also reduce propagation delay as well as improve timing efficiency. Finally, Quality of Service is also improved. We adopt the single-layer approach with the handshaking protocol for communication. We carried out the simulation utilizing Aqua-Sim Network Simulator 2. The simulation results showed that the proposed CAPL-MAC protocol achieved the earlier stated performance rather than by existing protocols such as Competitive Transmission-MAC and Channel Aware Aloh

Case series of trigonal meningiomas

Background Trigonal meningiomas have unique clinical presentation, unlike those in other areas of brain. Situated deep in the brain, the surgical nuances of this tumour are distinctive. We present our experience with this tumour including a discussion of surgical corridors that may be employed. Methods At our centre, 12 trigonal meningiomas were operated over past two decades. A retrospective analysis of case records of these cases was undertaken as regards age, sex clinical presentation, imaging and surgical approach. Results Mean time from heralding symptom to presentation was 10.4 months. At presentation, the most commonly encountered symptoms were those of non-localising symptoms attributable to raised ICP. Majority of lesions were more than 6 cm and on left side and the preferred surgical approach was inferior temporo-parietal. Most symptoms were relieved on long-term follow-up except homonymous hemianopia. Conclusion The incidence of deficit is low on employing the “shortest route” approach, even in the dominant hemisphere and through eloquent area. This may be secondary to possible shift of eloquent area function due to longstanding lesion and may thus be a “workable” surgical option, especially in resource-limited centres where such resources as neuronavigation and tractography may be unavailable

Aerodinamičan dizajn i analiza motorističke kacige s vizirom protiv odsjaja

The number of motorcycle accidents has increased in the last two decades. Helmet can protect the vehicle riders from severe injuries during road accident to certain extent. To design a functional helmet, it is important to analyse the shape of the helmet and visor portion. Therefore, the attempt has been made to design and analyze new helmet by considering the pressure drag and anti-glare visor. The pressure drag resistance presses the helmet against the neck portion of the rider. The shape of an aerodynamic helmet can reduce the drag pressure. The spherical shape and new aerodynamic shape helmets are designed using Pro-E software. Pressure drag is calculated and comparison is made on the basis of drag pressure.Broj motociklističkih nesreća u posljednja se dva desetljeća povećao. Kaciga u određenoj mjeri može zaštititi motocikliste od teških ozljeda koje je moguće zadobiti tijekom prometne nesreće. Prilikom dizajniranja funkcionalne kacige važno je analizirati oblik kacige i veličinu vizira. Iz tog se razloga pokušalo dizajnirati i analizirati novu kacigu uzimajući u obzir tlak otpora zraka i vizir protiv odsjaja. Tlak otpora zraka pritišće kacigu na vratni dio tijela vozača. Oblik aerodinamične kacige može smanjiti pritisak otpora zraka. Kacige sfernog oblika i novog aerodinamičnog oblika izrađene su pomoću Pro-E software-a. Izračunati su tlakovi otpora zraka za oba oblika kacige i napravljena je usporedba rezultata

Solar hydrogen generation from organic substance using earth abundant CuS–NiO heterojunction semiconductor photocatalyst

This work explores the critical role of NiO co-catalyst assembled on the surface of a CuS primary photocatalyst which effectively improves interface properties and enhances solar-to-hydrogen production by prolonging lifetime of photo-excitons generated at the CuS surface. The nanoscale CuS/NiO heterojunction is formulated using hydrothermal and wet impregnation methods. The resultant CuS/NiO composite shows optical absorbance between 380-780 nm region. The type-II energetic structure formed at CuS/NiO heterojunction facilitates rapid charge separation and as a result, the CuS/NiO composite exhibits 13 folds higher photocatalytic water splitting performance than CuO and NiO. The champion CuO/NiO photocatalyst is first identified by screening the catalysts using a preliminary water splitting test reaction under natural Sunlight irradiation. After the optimization of the catalyst, it was further explored for enhanced photocatalytic hydrogen production using different organic substances dispersed in water (alcohols, amine and organic acids). The champion CuS/NiO catalyst(CPN-2) exhibited the photocatalytic hydrogen production rate of 52.3 mmol.h-1.g-1cat in the presence of lactic acid-based aqueous electrolyte and, it is superior than hydrogen production rate obtained in the presence of other organic substances (triethanolamine, glycerol, ethylene glycol, methanol) tested under identical experimental conditions. These results indicate that the energetic structure of CuS/NiO photocatalyst is favorable for photocatalytic oxidation of lactic acid or reformation of lactic acid. The oxidation of lactic acid contributes oxidative electrons for enhanced hydrogen generation as well as protects CuS from photocorrosion. The modification of surface property and energetic structure of CuS photocatalyst by the NiO co-catalyst improves photogenerated charge carrier separation and in turn enhances the solar-to-hydrogen generation. The recyclability tests showed the potential of CPN-2 photocatalystfor prolonged photocatalytic hydrogen production while continuous supply of lactic acid feedstock is available

Power Quality Enhancement in Sensitive Local Distribution Grid Using Interval Type-II Fuzzy Logic Controlled DSTATCOM

In the current scenario, integration of renewables, growth of non-linear industrial and commercial loads results in various power quality issues. Among commercial utilities connected to the grid, hospital-operated loads include sensitive, linear, non-linear, and unbalanced loads. These loads are diverse as well as prioritized, which also causes major power quality issues in the local distribution system. Due to its widespread divergence, it leads to harmonic injection and reactive power imbalance. Distribution Static Compensator (DSTATCOM) is proposed as a solution for harmonic mitigation, load balancing, reactive power imbalances, and neutral current compensation. The present work utilizes Interval Type-2 Fuzzy Logic Controller (IT2FLC) with Recursive Least Square (RLS) filter for generating switching pulses for IGBT switches in the DSTATCOM to improve power quality in the Local Distribution Grid. The proposed approach also shows superior performance over Type 1 fuzzy logic controller and Conventional PI controller in mitigating harmonics. For effective realization, the proposed system is simulated using MATLAB software

Kaposi's Sarcoma-Associated Herpesvirus ORF45 Interacts with Kinesin-2 Transporting Viral Capsid-Tegument Complexes along Microtubules

Open reading frame (ORF) 45 of Kaposi's sarcoma-associated herpesvirus (KSHV) is a tegument protein. A genetic analysis with a null mutant suggested a possible role for this protein in the events leading to viral egress. In this study, ORF45 was found to interact with KIF3A, a kinesin-2 motor protein that transports cargoes along microtubules to cell periphery in a yeast two-hybrid screen. The association was confirmed by both co-immunoprecipitation and immunoflorescence approaches in primary effusion lymphoma cells following virus reactivation. ORF45 principally mediated the docking of entire viral capsid-tegument complexes onto the cargo-binding domain of KIF3A. Microtubules served as the major highways for transportation of these complexes as evidenced by drastically reduced viral titers upon treatment of cells with a microtubule depolymerizer, nocodazole. Confocal microscopic images further revealed close association of viral particles with microtubules. Inhibition of KIF3A–ORF45 interaction either by the use of a headless dominant negative (DN) mutant of KIF3A or through shRNA-mediated silencing of endogenous KIF3A expression noticeably decreased KSHV egress reflecting as appreciable reductions in the release of extracellular virions. Both these approaches, however, failed to impact HSV-1 egress, demonstrating the specificity of KIF3A in KSHV transportation. This study thus reports on transportation of KSHV viral complexes on microtubules by KIF3A, a kinesin motor thus far not implicated in virus transportation. All these findings shed light on the understudied but significant events in the KSHV life cycle, delineating a crucial role of a KSHV tegument protein in cellular transport of viral particles

Community Control of Hypertension and Diabetes (CoCo-HD) program in the Indian states of Kerala and Tamil Nadu : a study protocol for a type 3 hybrid trial

Introduction: India grapples with a formidable health challenge, with an estimated 315 million adults afflicted with hypertension and 100 million living with diabetes mellitus. Alarming statistics reveal rates for poor treatment and control of hypertension and diabetes. In response to these pressing needs, the Community Control of Hypertension and Diabetes (CoCo-HD) program aims to implement structured lifestyle interventions at scale in the southern Indian states of Kerala and Tamil Nadu. Aims: This research is designed to evaluate the implementation outcomes of peer support programs and community mobilisation strategies in overcoming barriers and maximising enablers for effective diabetes and hypertension prevention and control. Furthermore, it will identify contextual factors that influence intervention scalability and it will also evaluate the program’s value and return on investment through economic evaluation. Methods: The CoCo-HD program is underpinned by a longstanding collaborative effort, engaging stakeholders to co-design comprehensive solutions that will be scalable in the two states. This entails equipping community health workers with tailored training and fostering community engagement, with a primary focus on leveraging peer supportat scale in these communities. The evaluation will undertake a hybrid type III trial in, Kerala and Tamil Nadu states, guided by the Institute for Health Improvement framework. The evaluation framework is underpinned by the application of three frameworks, RE-AIM, Normalisation Process Theory, and the Consolidated Framework for Implementation Research. Evaluation metrics include clinical outcomes: diabetes and hypertension control rates, as well as behavioural, physical, and biochemical measurements and treatment adherence. Discussion: The anticipated outcomes of this study hold immense promise, offering important learnings into effective scaling up of lifestyle interventions for hypertension and diabetes control in low- and middle-income countries (LMICs). By identifying effective implementation strategies and contextual determinants, this research has the potential to lead to important changes in healthcare delivery systems. Conclusions: The project will provide valuable evidence for the scaling-up of structured lifestyle interventions within the healthcare systems of Kerala and Tamil Nadu, thus facilitating their future adaptation to diverse settings in India and other LMICs.Peer reviewe

Antagonism of Host Antiviral Responses by Kaposi's Sarcoma-Associated Herpesvirus Tegument Protein ORF45

Virus infection of a cell generally evokes an immune response by the host to defeat the intruder in its effort. Many viruses have developed an array of strategies to evade or antagonize host antiviral responses. Kaposi's sarcoma-associated herpesvirus (KSHV) is demonstrated in this report to be able to prevent activation of host antiviral defense mechanisms upon infection. Cells infected with wild-type KSHV were permissive for superinfection with vesicular stomatitis virus (VSV), suggesting that KSHV virions fail to induce host antiviral responses. We previously showed that ORF45, a KSHV immediate-early protein as well as a tegument protein of virions, interacts with IRF-7 and inhibits virus-mediated type I interferon induction by blocking IRF-7 phosphorylation and nuclear translocation (Zhu et al., Proc. Natl. Acad. Sci. USA. 99:5573-5578, 2002). Here, using an ORF45-null recombinant virus, we demonstrate a profound role of ORF45 in inhibiting host antiviral responses. Infection of cells with an ORF45-null mutant recombinant KSHV (BAC-stop45) triggered an immune response that resisted VSV super-infection, concomitantly associated with appreciable increases in transcription of type I IFN and downstream anti-viral effector genes. Gain-of-function analysis showed that ectopic expression of ORF45 in human fibroblast cells by a lentivirus vector decreased the antiviral responses of the cells. shRNA-mediated silencing of IRF-7, that predominantly regulates both the early and late phase induction of type I IFNs, clearly indicated its critical contribution to the innate antiviral responses generated against incoming KSHV particles. Thus ORF45 through its targeting of the crucial IRF-7 regulated type I IFN antiviral responses significantly contributes to the KSHV survival immediately following a primary infection allowing for progression onto subsequent stages in its life-cycle

Kaposi's Sarcoma Associated Herpes Virus (KSHV) Induced COX-2: A Key Factor in Latency, Inflammation, Angiogenesis, Cell Survival and Invasion

Kaposi's sarcoma (KS), an enigmatic endothelial cell vascular neoplasm, is characterized by the proliferation of spindle shaped endothelial cells, inflammatory cytokines (ICs), growth factors (GFs) and angiogenic factors. KSHV is etiologically linked to KS and expresses its latent genes in KS lesion endothelial cells. Primary infection of human micro vascular endothelial cells (HMVEC-d) results in the establishment of latent infection and reprogramming of host genes, and cyclooxygenase-2 (COX-2) is one of the highly up-regulated genes. Our previous study suggested a role for COX-2 in the establishment and maintenance of KSHV latency. Here, we examined the role of COX-2 in the induction of ICs, GFs, angiogenesis and invasive events occurring during KSHV de novo infection of endothelial cells. A significant amount of COX-2 was detected in KS tissue sections. Telomerase-immortalized human umbilical vein endothelial cells supporting KSHV stable latency (TIVE-LTC) expressed elevated levels of functional COX-2 and microsomal PGE2 synthase (m-PGES), and secreted the predominant eicosanoid inflammatory metabolite PGE2. Infected HMVEC-d and TIVE-LTC cells secreted a variety of ICs, GFs, angiogenic factors and matrix metalloproteinases (MMPs), which were significantly abrogated by COX-2 inhibition either by chemical inhibitors or by siRNA. The ability of these factors to induce tube formation of uninfected endothelial cells was also inhibited. PGE2, secreted early during KSHV infection, profoundly increased the adhesion of uninfected endothelial cells to fibronectin by activating the small G protein Rac1. COX-2 inhibition considerably reduced KSHV latent ORF73 gene expression and survival of TIVE-LTC cells. Collectively, these studies underscore the pivotal role of KSHV induced COX-2/PGE2 in creating KS lesion like microenvironment during de novo infection. Since COX-2 plays multiple roles in KSHV latent gene expression, which themselves are powerful mediators of cytokine induction, anti-apoptosis, cell survival and viral genome maintainence, effective inhibition of COX-2 via well-characterized clinically approved COX-2 inhibitors could potentially be used in treatment to control latent KSHV infection and ameliorate KS