A NARRATIVE REVIEW ON DEFINING AGING: A MULTIDISCIPLINARY REVIEW OF BIOLOGICAL, PSYCHOLOGICAL, SOCIOLOGICAL, AND CLINICAL PERSPECTIVES WITH A FOCUS ON SUCCESSFUL AGING.

Aging is a complex, multifaceted process affecting every living organism, characterized by progressive physiological changes, functional decline, and increased susceptibility to diseases and death. As the global population continues to age, understanding and defining aging becomes increasingly important for healthcare, policy-making, and social support systems. The review aims to explore and synthesize various definitions of aging, including biological, psychological, sociological, and clinical perspectives, and to examine the concept of successful aging. The review identifies distinct definitions of aging across different disciplines, highlighting the multifaceted nature of the idea. Biological aging involves cellular senescence, genetic theories, and damage accumulation. Psychological aging encompasses cognitive changes and emotional regulation, while sociological aging focuses on social roles and cultural attitudes. Clinical aging addresses the decline in physical and mental health and the emergence of geriatric syndromes. The maintenance of physical health, mental well-being, social engagement, and productive activities defines successful aging. Factors influencing successful aging include genetics, lifestyle choices, social support, and access to healthcare. Understanding the various definitions of aging is crucial for advancing research, developing effective interventions, and shaping policies that support healthy aging. Future research should explore the interplay between genetic, environmental, and social determinants of aging, and promote societal attitudes that value and support older adults. Insights from this review can inform the design of clinical programs and policies aimed at enhancing the quality of life for older adults. Emphasizing preventive measures, health promotion, and social support can help mitigate the negative impacts of aging and promote successful aging across populations

Numerics of High Performance Computers and Benchmark Evaluation of Distributed Memory Computers

The internal representation of numerical data, their speed of manipulation to generate the desired result through efficient utilisation of central processing unit, memory, and communication links are essential steps of all high performance scientific computations. Machine parameters, in particular, reveal accuracy and error bounds of computation, required for performance tuning of codes. This paper reports diagnosis of machine parameters, measurement of computing power of several workstations, serial and parallel computers, and a component-wise test procedure for distributed memory computers. Hierarchical memory structure is illustrated by block copying and unrolling techniques. Locality of reference for cache reuse of data is amply demonstrated by fast Fourier transform codes. Cache and register-blocking technique results in their optimum utilisation with consequent gain in throughput during vector-matrix operations. Implementation of these memory management techniques reduces cache inefficiency loss, which is known to be proportional to the number of processors. Of the two Linux clusters-ANUP16, HPC22 and HPC64, it has been found from the measurement of intrinsic parameters and from application benchmark of multi-block Euler code test run that ANUP16 is suitable for problems that exhibit fine-grained parallelism. The delivered performance of ANUP16 is of immense utility for developing high-end PC clusters like HPC64 and customised parallel computers with added advantage of speed and high degree of parallelism

Outcome of expectant line of management in early onset (24-32weeks) pregnancy induced hypertension

Background: Preeclampsia is a disease of multiple organ systems that is unique to pregnancy and is often associated with increased risk of maternal-perinatal adverse outcome, especially when it is severe and occurs well before term.The objective of the study was to study expectant line of management in early onset pregnancy induced hypertension (24-32 weeks) and its maternal and perinatal outcome in relation to preterm delivery, IUD/ Still birth, and early neonatal deaths.Methods: Total 100 patients presented with early onset pregnancy induced hypertension admitted in Pravara Medical College and Hospital. 50 patient’s pregnancy terminated (Aggressive Group) depending on patients clinical profile and other 50 patients given expectant line of management and pregnancy was prolonged (Expectant Group). Maternal and perinatal outcome was compared between the two groups.Results: No maternal mortality was seen in both groups.Perinatal mortality in aggressive line of management was 54% while in expectant line of management perinatal mortality was 30%. Neonatal deaths account for 24% in aggressive group and 10% in expectant group. Fetal survival rate in expectant group was 70% and in aggressive group it was 46%.Conclusions: Expectant management of severe preeclampsia at 24 to 32 weeks in a tertiary care center is associated with good perinatal outcome with a minimal risk for the mother.The early use of antihypertensive drugs, optimum timing of delivery and strict fluid balance will help to achieve successful outcome

Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report.

BACKGROUND: Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here. CASE PRESENTATION: A formerly healthy 40 year-old male became symptomatic 10 days after spending time in the jungle of North Borneo. Four days later, he presented to hospital in a state of collapse and died within two hours. He was hyponatraemic and had elevated blood urea, potassium, lactate dehydrogenase and amino transferase values; he was also thrombocytopenic and eosinophilic. Dengue haemorrhagic shock was suspected and a post-mortem examination performed. Investigations for dengue virus were negative. Blood for malaria parasites indicated hyperparasitaemia and single species P. knowlesi infection was confirmed by nested-PCR. Macroscopic pathology of the brain and endocardium showed multiple petechial haemorrhages, the liver and spleen were enlarged and lungs had features consistent with ARDS. Microscopic pathology showed sequestration of pigmented parasitized red blood cells in the vessels of the cerebrum, cerebellum, heart and kidney without evidence of chronic inflammatory reaction in the brain or any other organ examined. Brain sections were negative for intracellular adhesion molecule-1. The spleen and liver had abundant pigment containing macrophages and parasitized red blood cells. The kidney had evidence of acute tubular necrosis and endothelial cells in heart sections were prominent. CONCLUSIONS: The overall picture in this case was one of systemic malaria infection that fit the WHO classification for severe malaria. Post-mortem findings in this case were unexpectedly similar to those that define fatal falciparum malaria, including cerebral pathology. There were important differences including the absence of coma despite petechial haemorrhages and parasite sequestration in the brain. These results suggest that further study of knowlesi malaria will aid the interpretation of, often conflicting, information on malaria pathophysiology in humans

Origin of Large Dielectric Constant with Large Remnant Polarization and Evidence of Magnetoelectric Coupling in Multiferroic La modified BiFeO3-PbTiO3 Solid Solution

The presence of superlattice reflections and detailed analyses of the powder neutron and x-ray diffraction data reveal that La rich (BF$_{0.50}$-LF$_{0.50}$)$_{0.50}$-(PT)$_{0.50}$ (BF-LF-PT) has ferroelectric rhombohedral crystal structure with space group \textit{$R3c$} at ambient conditions. The temperature dependence of lattice parameters, tilt angle, calculated polarization $(P_{s})$, volume, and integrated intensity of superlattice and magnetic reflections show an anomaly around 170 K. Impedance spectroscopy, dielectric and ac conductivity measurements were performed in temperature range $473K \leq T \leq 573K$ to probe the origin of large remnant polarization and frequency dependent broad transitions with large dielectric constant near $T_c^{FE}$. Results of impedance spectroscopy measurements clearly show contributions of both grain and grain boundaries throughout the frequency range ($10^{3}$ Hz$\leq f\leq 10^{7}$ Hz). It could be concluded that the grain boundaries are more resistive and capacitive as compared to the grains, resulting in inhomogeneities in the sample causing broad frequency dependent dielectric anomalies. Enhancement in dielectric constant and remnant polarization values are possibly due to space charge polarization caused by piling of charges at the interface of grains and grain boundaries. The imaginary parts of dielectric constant ($\epsilon^{\prime\prime}$) Vs frequency data were fitted using Maxwell-Wagner model at $T_c^{FE}(\sim 523$K) and model fits very well with the data up to $10^{5}$ Hz. Magnetodielectric measurements prove that the sample starts exhibiting magnetoelectric coupling at $\sim 170$ K, which is also validated by neutron diffraction data.Comment: 20 pages, 10 figure

Studies on the Performance of Air Cyclone Separator for Removal of Particulate Matter

Emissions from industries and air pollution from these emissions adversely affects the environment and public health. For instance, India depends largely on coal for its power generation. The problem with Indian coal is that it carries a lot of dust with it. Hence, dust carried along with the flue gases has to be separated before sending the gases for further treatment. Cyclone separa-tor, bag filter and electrostatic precipitator have found applications in technological use. ESP demands high voltage (power requirements) whereas general bag filters cannot work beyond 120C. However, cyclone separators have less temperature and pressure limitations and requires low pressure drop. Hence, cyclone separators are usually selected to separate dust from fluid streams