171 research outputs found
Dubai Real Estate Investment: A Predictive and Time Series Analysis
The capstone aims to provide real estate investors suitable portfolios for investment in Dubai, considering maximum return on investment as per their investment goals. CRISP-DM methodology was used as it is a structured approach for planning a data mining project. The datasets from Dubai Land Department, RERA and Property Finder was used to conduct Exploratory Analysis, Predictive Analysis using Linear Regression, Random Forest Regression, Decision Tree Regression, Gradient Boost Regression and Time Series analysis using Exponential Smoothing, Holt forecasting, Holt Winter Method, ARIMA and SARIMA. To facilitate investors in easily searching for suitable portfolio to invest in based on their preference, a web platform has been designed. This platform also provides the option of using Predictive Analysis for estimating the returns. The best result for Predictive Analysis was provided by Gradient Boost Regression and for Time Series Analysis was provided by SARIMA model as the dataset includes seasonality
Transcriptomic Analysis of Early B-Cell Development in the Chicken Embryo
The chicken bursa of Fabricius is a primary lymphoid tissue important for B-cell development. Our long-term goal is to understand the role of bursal microenvironment in an early B-cell differentiation event initiating repertoire development through immunoglobulin gene-conversion in the chick embryo. We hypothesize that early bursal B-cell differentiation is guided by signals through cytokine receptors. Our theory is based on previous evidence for expression of the receptor tyrosine kinase superfamily members and interleukin receptors in unseparated populations of bursal B-cells and bursal tissue. Knowledge of the expressed genes that are responsible for B-cell differentiation is a prerequisite for understanding the bursal microenvironment’s function. This project uses transcriptomic analysis to examine gene expression across an early B-cell differentiation event. RNA-seq was performed with total RNA isolated from developing B-cells at embryonic day (ED) 16 and ED 19 (n=3). Approximately 90 million high quality clean reads where obtained from the cDNA libraries. The analysis revealed differentially expressed genes involved in Wnt signaling pathway, Jak-STAT pathway, metabolic pathways, tyrosine metabolism, Toll-like receptor signaling pathway, MAPK signaling pathway, and cellhesion molecules. The transcripts for surface receptors, signal transduction and transcription factors identified in this study represent gene candidates for controlling B-cell differentiation in response to bursal microenvironmental factors
Gate controlled large resistance switching driven by charge density wave in 1T-TaS2/2H-MoS2 heterojunction
1T-TaS2 is a layered material that exhibits charge density wave (CDW) induced
distinct electrical resistivity phases and has attracted a lot of attention for
interesting device applications. However, such resistivity switching effects
are often weak, and cannot be modulated by an external gate voltage - limiting
their widespread usage. Using a back-gated 1T-TaS2/2H-MoS2 heterojunction, here
we show that the usual resistivity switching in TaS2 due to different phase
transitions is accompanied with a surprisingly strong modulation in the
Schottky barrier height (SBH) at the TaS2/MoS2 interface - providing an
additional knob to control the degree of the phase-transition-driven
resistivity switching by an external gate voltage. In particular, the
commensurate (C) to triclinic (T) phase transition results in an increase in
the SBH owing to a collapse of the Mott gap in TaS2. The change in SBH allows
us to estimate an electrical Mott gap opening of ~71 +/- 7 meV in the C phase
of TaS2. On the other hand, the nearly-commensurate (NC) to incommensurate (IC)
phase transition results in a suppression in the SBH, and the heterojunction
shows a gate-controlled resistivity switching up to 17.3, which is ~14.5 times
higher than that of standalone TaS2. The findings mark an important step
forward showing a promising pathway to externally control as well as amplify
the CDW induced resistivity switching. This will boost device applications that
exploit these phase transitions, such as ultra-broadband photodetection,
negative differential conductance, fast oscillator and threshold switching in
neuromorphic circuits.Comment: Accepted for publication in Physical Review Applie
Selective Laser Sintering and Freeze Extrusion Fabrication of Scaffolds for Bone Repair using 13-93 Bioactive Glass: A Comparison
13-93 glass is a third-generation bioactive material which accelerates the bone’s natural ability to heal by itself through bonding with surrounding tissues. It is an important requirement for synthetic scaffolds to maintain their bioactivity and mechanical strength with a porous internal architecture comparable to that of a human bone. Additive manufacturing technologies provide a better control over design and fabrication of porous structures than conventional methods. In this paper, we discuss and compare some of the common aspects in the scaffold fabrication using two such processes, viz. selective laser sintering (SLS) and freeze extrusion fabrication (FEF). Scaffolds fabricated using each process were structurally characterized and microstructure analysis was performed to study process differences. Compressive strength higher than that of human trabecular bone was achieved using SLS process and strength almost comparable to that of human cortical bone was achieved using FEF process
On-chip TIRF nanoscopy by applying Haar wavelet kernel analysis on intensity fluctuations induced by chip illumination
Photonic-chip based TIRF illumination has been used to demonstrate several
on-chip optical nanoscopy methods. The sample is illuminated by the evanescent
field generated by the electromagnetic wave modes guided inside the optical
waveguide. In addition to the photokinetics of the fluorophores, the waveguide
modes can be further exploited for introducing controlled intensity
fluctuations for exploitation by techniques such as super-resolution optical
fluctuation imaging (SOFI). However, the problem of non-uniform illumination
pattern generated by the modes contribute to artifacts in the reconstructed
image. To alleviate this problem, we propose to perform Haar wavelet kernel
(HAWK) analysis on the original image stack prior to the application of (SOFI).
HAWK produces a computational image stack with higher spatio-temporal sparsity
than the original stack. In the case of multimoded non-uniform illumination
patterns, HAWK processing bre aks the mode pattern while introducing
spatio-temporal sparsity, thereby differentially affecting the non-uniformity
of the illumination. Consequently, this assists nanoscopy methods such as SOFI
to better support super-resolution, which is otherwise compromised due to
spatial correlation of the mode patterns in the raw image. Furthermore,
applying HAWK prior to SOFI alleviates the problem of artifacts due to
non-uniform illumination without degrading temporal resolution. Our
experimental results demonstrate resolution enhancement as well as reduction in
artifacts through the combination of HAWK and SOFI
Urinary Biomarkers: Mitigating Diagnostic Delays of Bladder Cancer in the COVID-19 era
© 2020, Springer Nature Limited. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1038/s41585-020-00419-zThe COVID-19 pandemic has resulted in a substantial increase in waiting times for cystoscopies, prompting concerns of delayed diagnoses and substandard surveillance of bladder cancer. Expanding the role of urinary biomarkers in diagnostic and surveillance pathways could be a strategy to address this problem, and several novel biomarkers have shown promise for this purpose.Peer reviewe
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