131 research outputs found
Weighing the Milky Way
We describe an experiment to measure the mass of the Milky Way galaxy. The
experiment is based on calculated light travel times along orthogonal
directions in the Schwarzschild metric of the Galactic center. We show that the
difference is proportional to the Galactic mass. We apply the result to light
travel times in a 10cm Michelson type interferometer located on Earth. The mass
of the Galactic center is shown to contribute 10^-6 to the flat space component
of the metric. An experiment is proposed to measure the effect.Comment: 10 pages, 1 figur
Millimeter-wave Signature of Strange Matter Stars
One of the most important questions in the study of compact objects is the
nature of pulsars, including whether they consist of neutron matter or strange
quark matter (SQM). However, few mechanisms for distinguishing between these
two possibilities have been proposed. The purpose of this paper is to show that
a strange star (one made of SQM) will have a vibratory mode with an oscillation
frequency of approximately 250 GHz (millimeter wave). This mode corresponds to
motion of the center of the expected crust of normal matter relative to the
center of the strange quark core, without distortion of either. Radiation from
currents generated in the crust at the mode frequency would be a SQM signature.
We also consider effects of stellar rotation, estimate power emission and
signal-to-noise ratio, and discuss briefly possible mechanisms for exciting the
mode.Comment: 13 pages, Latex, one figur
Gravitational ultrarelativistic spin-orbit interaction and the weak equivalence principle
It is shown that the gravitational ultrarelativistic spin-orbit interaction
violates the weak equivalence principle in the traditional sense. This fact is
a direct consequence of the Mathisson-Papapetrou equations in the frame of
reference comoving with a spinning test particle. The widely held assumption
that the deviation of a spinning test body from a geodesic trajectory is caused
by tidal forces is not correctComment: 12 page
Optical fibers with interferometric path length stability by controlled heating for transmission of optical signals and as components in frequency standards
We present a simple method to stabilize the optical path length of an optical
fiber to an accuracy of about 1/100 of the laser wavelength. We study the
dynamic response of the path length to modulation of an electrically conductive
heater layer of the fiber. The path length is measured against the laser
wavelength by use of the Pound-Drever-Hall method; negative feedback is applied
via the heater. We apply the method in the context of a cryogenic resonator
frequency standard.Comment: Expanded introduction and outlook. 9 pages, 5 figure
Dynamics of Trophoblast Differentiation in Peri-Implantation–Stage Human Embryos
Single-cell RNA sequencing of cells from cultured human blastocysts has enabled us to define the transcriptomic landscape of placental trophoblast (TB) that surrounds the epiblast and associated embryonic tissues during the enigmatic day 8 (D8) to D12 peri-implantation period before the villous placenta forms. We analyzed the transcriptomes of 3 early placental cell types, cytoTB (CTB), syncytioTB (STB), and migratoryTB (MTB), picked manually from cultured embryos dissociated with trypsin and were able to follow sublineages that emerged from proliferating CTB at the periphery of the conceptus. A unique form of CTB with some features of STB was detectable at D8, while mature STB was at its zenith at D10. A form of MTB with a mixed MTB/CTB phenotype arose around D10. By D12, STB generation was in decline, CTB had entered a new phase of proliferation, and mature MTB cells had begun to move from the main body of the conceptus. Notably, the MTB transcriptome at D12 indicated enrichment of transcripts associated with IFN signaling, migration, and invasion and upregulation of HLA-C, HLA-E, and HLA-G. The STB, which is distinct from the STB of later villous STB, had a phenotype consistent with intense protein export and placental hormone production, as well as migration and invasion. The studies show that TB associated with human embryos is in rapid developmental flux during periimplantation period when it must invade, signal robustly to the mother to ensure that the pregnancy continues, and make first contact with the maternal immune system
Lorentz Covariant Theory of Light Propagation in Gravitational Fields of Arbitrary-Moving Bodies
The Lorentz covariant theory of propagation of light in the (weak)
gravitational fields of N-body systems consisting of arbitrarily moving
point-like bodies with constant masses is constructed. The theory is based on
the Lienard-Wiechert presentation of the metric tensor. A new approach for
integrating the equations of motion of light particles depending on the
retarded time argument is applied. In an approximation which is linear with
respect to the universal gravitational constant, G, the equations of light
propagation are integrated by quadratures and, moreover, an expression for the
tangent vector to the perturbed trajectory of light ray is found in terms of
instanteneous functions of the retarded time. General expressions for the
relativistic time delay, the angle of light deflection, and gravitational red
shift are derived. They generalize previously known results for the case of
static or uniformly moving bodies. The most important applications of the
theory are given. They include a discussion of the velocity dependent terms in
the gravitational lens equation, the Shapiro time delay in binary pulsars, and
a precise theoretical formulation of the general relativistic algorithm of data
processing of radio and optical astrometric measurements in the non-stationary
gravitational field of the solar system. Finally, proposals for future
theoretical work being important for astrophysical applications are formulated.Comment: 77 pages, 7 figures, list of references is updated, to be published
in Phys. Rev. D6
Probing the Microscopic Origin of Gravity via Precision Polarization and Spin Experiments
As in other parts of physics, we advocate the interaction approach:
experiments phenomenology low-energy effective (field) theory
microscopic theory to probe the microscopic origin of gravity. Using chi-g
phenomenological framework, we discuss the tests of equivalence principles. The
only experimentally unconstrained degree of freedom is the axion freedom. It
has effects on the long-range astrophysical/cosmological propagation of
electromagnetic waves and can be tested/measured using future generation of
polarization measurement of cosmic background radiation. The verification or
refutal of this axionic effect will be a crucial step for constructing
effective theory and probing the microscopic origin of gravity. The interaction
of spin with gravity is another important clue for probing microscopic origin
of gravity. The interplay of experiments, phenomenology and effective theory is
expounded. An ideal way to reveal the microscopic origin of gravity is to
measure the gyrogravitational ratio of particles. Three potential experimental
methods are considered.Comment: 8 pages; 1 figur
Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology
Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment and have been associated with subfertility arising from reduced oocyte developmental competence. We have asked whether elevated NEFA concentrations during oocyte maturation affect the development and physiology of zygotes formed from such oocytes, using the cow as a model. The zygotes were grown to blastocysts, which were evaluated for their quality in terms of cell number, apoptosis, expression of key genes, amino acid turnover and oxidative metabolism. Oocyte maturation under elevated NEFA concentrations resulted in blastocysts with significantly lower cell number, increased apoptotic cell ratio and altered mRNA abundance of DNMT3A, IGF2R and SLC2A1. In addition, the blastocysts displayed reduced oxygen, pyruvate and glucose consumption, up-regulated lactate consumption and higher amino acid metabolism. These data indicate that exposure of maturing oocytes to elevated NEFA concentrations has a negative impact on fertility not only through a reduction in oocyte developmental capacity but through compromised early embryo quality, viability and metabolism
Utilization of endogenous fatty acid stores for energy production in bovine preimplantation embryos
Although current embryo culture media are based on carbohydrate metabolism of embryos, little is known about metabolism of endogenous lipids. L-carnitine is a β-oxidation cofactor absent in most culture media. The objective was to investigate the influence of L-carnitine supplementation on bovine embryo development. Abattoir-derived bovine cumulus oocyte complexes were cultured and fertilized. Post-fertilization, presumptive zygotes were transferred into a basic cleavage medium ± carbohydrates (glucose, lactate and pyruvate) ± 5 mm L-carnitine and cultured for 4 days in vitro. In the absence of carbohydrates during culture, embryos arrested at the 2- and 4-cell stages. Remarkably, +L-carnitine increased development to the morula stage compared to +carbohydrates alone (P < 0.001). The beneficial effects of L-carnitine were further demonstrated by inclusion of carbohydrates, with 14-fold more embryos reaching the morula stage after culture in the +carbohydrates +L-carnitine group compared to the +carbohydrates group (P < 0.05). Whereas there was a trend for +L-carnitine to increase ATP (P = 0.09), ADP levels were higher and ATP: ADP ratio were 1.9-fold lower (main effect, P < 0.05) compared to embryos cultured in -L-carnitine. Therefore, we inferred that +L-carnitine embryos were more metabolically active, with higher rates of ATP-ADP conversion. In conclusion, L-carnitine supplementation supported precompaction embryo development and there was an additive effect of +L-carnitine +carbohydrates on early embryo development, most likely through increased β-oxidation within embryos.Melanie L. Sutton-McDowall, Deanne Feil, Rebecca L. Robker, Jeremy G. Thompson, Kylie R. Dunnin
The Confrontation between General Relativity and Experiment
The status of experimental tests of general relativity and of theoretical
frameworks for analysing them is reviewed. Einstein's equivalence principle
(EEP) is well supported by experiments such as the Eotvos experiment, tests of
special relativity, and the gravitational redshift experiment. Future tests of
EEP and of the inverse square law are searching for new interactions arising
from unification or quantum gravity. Tests of general relativity at the
post-Newtonian level have reached high precision, including the light
deflection, the Shapiro time delay, the perihelion advance of Mercury, and the
Nordtvedt effect in lunar motion. Gravitational-wave damping has been detected
in an amount that agrees with general relativity to better than half a percent
using the Hulse-Taylor binary pulsar, and other binary pulsar systems have
yielded other tests, especially of strong-field effects. When direct
observation of gravitational radiation from astrophysical sources begins, new
tests of general relativity will be possible.Comment: 89 pages, 8 figures; an update of the Living Review article
originally published in 2001; final published version incorporating referees'
suggestion
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