81 research outputs found
Optimization of DMOS Transistors for Smart Power Technologies by Simulation and Response Surface Methods
Abstract DMOS transistors for smart power technologies were investigated by extensive use of process and device simulation. For the task of simultaneously optimizing a multitude of parameters. experimental designs and response surface methods were used
TGA2 signaling in response to reactive electrophile species is not dependent on cysteine modification of TGA2
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Reactive electrophile species (RES), including prostaglandins, phytoprostanes and 12-oxo phytodienoic acid (OPDA), activate detoxification responses in plants and animals. However, the pathways leading to the activation of defense reactions related to abiotic or biotic stress as a function of RES formation, accumulation or treatment are poorly understood in plants. Here, the thiol-modification of proteins, including the RES-activated basic region/leucine zipper transcription factor TGA2, was studied. TGA2 contains a single cysteine residue (Cys186) that was covalently modified by reactive cyclopentenones but not required for induction of detoxification genes in response to OPDA or prostaglandin A1. Activation of the glutathione-S-transferase 6 (GST6) promoter was responsive to cyclopentenones but not to unreactive cyclopentanones, including jasmonic acid suggesting that thiol reactivity of RES is important to activate the TGA2-dependent signaling pathway resulting in GST6 activation We show that RES modify thiols in numerous proteins in vivo, however, thiol reactivity alone appears not to be sufficient for biological activity as demonstrated by the failure of several membrane permeable thiol reactive reagents to activate the GST6 promoter.Peer reviewedFinal Published versio
Verteilung gefarbter ascitestumorzellen im organismus nach intra- venoser bzw. Intracardialer injektion bei der maus, ein beitrag zur experimentellen metastasierung.
�ber den Einfluss von Iso-Nicotins�ure-Hydrazid (INH) auf die Metastasierungsquote des Ehrlichschen Ascitescarcinom der Maus
Uber infectiositat und ubertragungsweise der virusbedingten myelois- chen leukamie der maus.
Untersuchungen zur naturlichen infektiositat der virusbedingten myeloischen leukamie der maus.
Uber das vorkommen des virus der myeloischen leukamie der maus in verschiedenen organen und zu verschiedenen zeitpunkten nach kunst- licher infection.
Uber die eignung von fluorocarbon fur die aureicherung des virus der myeloischen leukamie der maus.
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