A Management Survey by the Naval Officers in the Management Engineering Program

This management survey provides the opportunity for the officers to apply the theoretical and practical concepts and philosophies to an existing and successful industrial concern. It is inevitable that the past experiences and specializations of the officers will be superimposed on their recent scholastic development in their respective survey areas. Major effort has been directed towards molding these concepts into a combined, practicable, and objective approach to the survey. Arrangements for the study were made by the Department of Management Engineering, Rensselaer Polytechnic Institute.Master Table of Contents. VOLUME I: Foreword; Summary of Major Recommendations; Chapter I--Organization; Chapter II — Industrial Relations; Chapter III—Plant Protection; Chapter IV—Plant Property; Chapter V-Office Procedures. VOLUME II: Chapter VI—Accounting; Chapter VII—Traffic; Chapter VIII-Engineering; Chapter IX--Sales, Service, and Advertising Chapter X—Quality Control. VOLUME III: Chapter XI—Manufacturing (Part One); VOLUME IV; Chapter XI (Part Two); hapter XII—Bibliographyhttp://www.archive.org/details/managementsurvey00cla

Will the fair trade revolution be marketised? Commodification, decommodification and the political intensity of consumer politics

This paper brings to the fore a scrutiny of the politicisation of commodities in an exploration of the political promises and potential of ethical or political consumerism and specifically the case of fair trade. The analysis is informed by interviews with ethically consuming citizens which illuminate their concerns, certainties and confusions. I discuss consumer agency in relation to decommodification and branding as detrimental to the political qualities of the movement where the selling of fair trade is viewed through the prism of brand trust and the symbolised political quality of the commodity. Similarly, there is a corporate ‘veiling’ of consumer politics where the commercial sense which mainstream fair trade commodities enjoy is being manipulated through strategies of co-branding, thus signalling further distance from the older radical character of fair trade political consumerism. Thus, the decommodification of fair trade products is perhaps at the expense of the commodification of fair trade consumer politics

Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor beta Signaling

BACKGROUND: The X-chromosome gene USP9X encodes a deubiquitylating enzyme that has been associated with neurodevelopmental disorders primarily in female subjects. USP9X escapes X inactivation, and in female subjects de novo heterozygous copy number loss or truncating mutations cause haploinsufficiency culminating in a recognizable syndrome with intellectual disability and signature brain and congenital abnormalities. In contrast, the involvement of USP9X in male neurodevelopmental disorders remains tentative.METHODS: We used clinically recommended guidelines to collect and interrogate the pathogenicity of 44 USP9X variants associated with neurodevelopmental disorders in males. Functional studies in patient-derived cell lines and mice were used to determine mechanisms of pathology.RESULTS: Twelve missense variants showed strong evidence of pathogenicity. We define a characteristic phenotype of the central nervous system (white matter disturbances, thin corpus callosum, and widened ventricles); global delay with significant alteration of speech, language, and behavior; hypotonia; joint hypermobility; visual system defects; and other common congenital and dysmorphic features. Comparison of in silico and phenotypical features align additional variants of unknown significance with likely pathogenicity. In support of partial loss-of-function mechanisms, using patient-derived cell lines, we show loss of only specific USP9X substrates that regulate neurodevelopmental signaling pathways and a united defect in transforming growth factor signaling. In addition, we find correlates of the male phenotype in Usp9x brain-specific knockout mice, and further resolve loss of hippocannpal-dependent learning and memory.CONCLUSIONS: Our data demonstrate the involvement of USP9X variants in a distinctive neurodevelopmental and behavioral syndrome in male subjects and identify plausible mechanisms of pathogenesis centered on disrupted transforming growth factor beta signaling and hippocampal function.Genetics of disease, diagnosis and treatmen