Dengue Infection in Children in Ratchaburi, Thailand: A Cohort Study. II. Clinical Manifestations

Dengue infection is one of the most important diseases transmitted to human by mosquito bite. The disease may be mild or severe. This study reveals the occurrence and clinical features of diseases caused by dengue infection in a 3-year follow-up in school-children aged 3–14 years in Ratchaburi Province, Thailand using an active surveillance for the episodes of fever. Children who had fever were laboratory tested for the evidence of dengue infection and recorded for clinical features. It was found that most of dengue infected patients had headache, anorexia, nausea/vomiting, and muscle ache. About half of the patients had clinical symptoms that closely mimic other diseases, especially respiratory tract infection, and were incorrectly diagnosed by pediatricians. Only 11% of the patients had more a severe disease called “dengue hemorrhagic fever.” This severe disease may be predicted by the presence of anorexia, nausea/vomiting, and abdominal pain after the second day of illness. This study provides better understanding in this disease

Dengue in Thailand and Cambodia: An Assessment of the Degree of Underrecognized Disease Burden Based on Reported Cases

Dengue is a major public health problem especially in tropical and subtropical countries of Asia and Latin-America. An effective dengue vaccine is not yet available, but several vaccine candidates are currently being evaluated in clinical trials. Accurate country-level incidence data are crucial to assess the cost-effectiveness of such vaccines and will assist policy-makers in making vaccine introduction decisions. Existing national surveillance systems are often passive and are designed to monitor trends and to detect disease outbreaks. Our analyses of data from prospectively followed cohorts with laboratory confirmation of dengue cases show that, in Thailand and Cambodia, dengue incidence is underrecognized by more than 8-fold. The magnitude of the outpatient burden caused by dengue is not assessed or reflected by the national surveillance data. We estimate that a median of more than 340,000 symptomatic dengue virus infections occurred annually in children less than 15 years of age in Thailand in Cambodia between 2003 and 2007

Results of literature search and evaluation of identified data sources according PRISMA.

<p>Duplicates and articles that did not satisfy the inclusion criteria were removed following evaluation of the titles and abstracts. The full text of these documents was examined to facilitate the final selection of relevant articles. Included publications were collated and summarized using a data extraction instrument developed as a series of spreadsheets, as described in the protocol.</p

Epidemiological Trends of Dengue Disease in Thailand (2000–2011): A Systematic Literature Review

<div><p></p><p>A literature survey and analysis was conducted to describe the epidemiology of dengue disease in Thailand reported between 2000 and 2011. The literature search identified 610 relevant sources, 40 of which fulfilled the inclusion criteria defined in the review protocol. Peaks in the number of cases occurred during the review period in 2001, 2002, 2008 and 2010. A shift in age group predominance towards older ages continued through the review period. Disease incidence and deaths remained highest in children aged ≤15 years and case fatality rates were highest in young children. Heterogeneous geographical patterns were observed with higher incidence rates reported in the Southern region and serotype distribution varied in time and place. Gaps identified in epidemiological knowledge regarding dengue disease in Thailand provide several avenues for future research, in particular studies of seroprevalence.</p><p>Protocol registration</p><p>PROSPERO <a href="http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42012002170" target="_blank">CRD42012002170</a></p></div

Number of reported dengue disease cases and dengue disease incidence, Thailand, 2000–2011 [23]–[34].

<p>The number of reported dengue disease cases is plotted against the left-hand vertical axis. Peaks in the number of cases (national epidemics) that were above the 75^th percentile for the period occurred in 2001, 2002 and 2010; another peak (which was at the 70^th percentile) occurred in 2008. The incidence of dengue disease per 100,000 population is plotted against the right-hand vertical axis. The incidence averaged 115 cases annually between 2000 and 2011. No clear trend over time in the number or incidence of reported dengue disease cases could be discerned as the pattern over the review period was complicated by epidemic years.</p

Change in pattern of circulating dengue virus serotypes by year and region, Thailand, 2005–2010 [28]–[33].

<p>Regional DENV serotype data for the period 2005–2010 show similar patterns in each region. Broadly, there was a reduction in the proportion of DENV-1 and an increase in the proportion of DENV-2 in all regions. The proportion of DENV-3 was variable by time and between regions, whereas DENV-4 only remained in circulation throughout this 5-year period in the Central region. DENV, dengue virus. *Data for 2000–2004 not available from source material.</p

Pattern of reported cases and incidence of dengue disease, by age, Thailand, 2000–2011 [23]–[34].

<p>Dengue disease is a disease of children and young adults in Thailand. Panel (a) shows that most reported cases between 2003 and 2011* are in individuals aged between 5 and 24 years. There was a shift in age group predominance of dengue disease over the survey period from younger towards older individuals. The age-related incidence per 100,000 population between 2000 and 2010 (b) reveals the highest incidence rates were in those aged 10–14 years. *Age bands for 2011 differ (0–5, 6–10, 11–14, 15–24, 25–34, 35–44, 45–54, 55+) and do not match bands for disease numbers: consequently, some 2011 incidence figures are estimates.</p

Reported dengue disease incidence by region, Thailand, 2000–2011 [23]–[34].

<p>The patterns of regional dengue disease case numbers broadly reflected those observed nationally. The reported incidence of dengue disease was highest in the South region in 2001, 2002, 2005, 2007 and 2010.</p

Reported cases of dengue fever, dengue haemorrhagic fever and dengue shock syndrome, Thailand, 2000–2011 [23]–[34].

<p>The contribution of DSS to the total number of dengue disease cases remained relatively stable over the decade. Over the same period, the proportion of the total dengue disease cases classified as DF tended to increase year-on-year (with the exception of 2010–2011) whereas the contribution of DHF to the total number of dengue disease cases decreased. DF, dengue fever; DHF, dengue haemorrhagic fever; DSS, dengue shock syndrome.</p