4 research outputs found
Model System for Cell Adhesion Mediated by Weak Carbohydrate–Carbohydrate Interactions
The multivalent carbohydrate–carbohydrate interaction
between
membrane-anchored epitopes derived from the marine sponge <i>Microciona prolifera</i> has been explored by colloidal probe
microscopy. An <i>in situ</i> coupling of sulfated and non-sulfated
disaccharides to membrane-coated surfaces was employed to mimic native
cell–cell contacts. The dynamic strength of the homomeric self-association
was measured as a function of calcium ions and loading
rate. A deterministic model was used to estimate the basic energy landscape and number of participating
bonds in the contact zone